Fanconi anaemia: from a monogenic disease to sporadic cancer

BRCA-FA Pathway as a Target for Anti-Tumor Drugs

(2012) Rachel Litman et al.   Anti-Cancer Agents in Medicinal Chemistry

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

(2010) Craig MacKay et al.   CELL

Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents

(2010) Katja Kratz et al.   CELL

Expanded roles of the Fanconi anemia pathway in preserving genomic stability

(2010) Y. Kee et al.   GENES & DEVELOPMENT

FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth

(2010) Jun Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Spontaneous abrogation of the G2 DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients

(2010) Raphael Ceccaldi et al.   JOURNAL OF CLINICAL INVESTIGATION

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors

(2010) Igor Landais et al.   Molecular Cancer

Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents

(2010) Andreas Palagyi et al.   Molecular Cancer

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

(2010) M. C. Villarroel et al.   MOLECULAR CANCER THERAPEUTICS

Expression of Oncogenic Kinase Bcr-Abl Impairs Mitotic Checkpoint and Promotes Aberrant Divisions and Resistance to Microtubule-Targeting Agents

(2010) K. Wolanin et al.   MOLECULAR CANCER THERAPEUTICS

A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

(2010) Agata Smogorzewska et al.   MOLECULAR CELL

Mutation of the RAD51C gene in a Fanconi anemia–like disorder

(2010) Fiona Vaz et al.   NATURE GENETICS

Inactivation of the Tumor Suppressor Genes Causing the Hereditary Syndromes Predisposing to Head and Neck Cancer via Promoter Hypermethylation in Sporadic Head and Neck Cancers

(2010) Ian M. Smith et al.   ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery

Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells

(2010) Antonio Valeri et al.   PLoS One

FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

(2010) T. Liu et al.   SCIENCE

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors

(2009) Clark C Chen et al.   Molecular Cancer

FANCM–FAAP24 and FANCJ: FA proteins that metabolize DNA

(2009) Abdullah Mahmood Ali et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease Progression

(2008) Wei Du et al.   ANTIOXIDANTS & REDOX SIGNALING

Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer

(2008) S L Lim et al.   BRITISH JOURNAL OF CANCER

Promoter Hypermethylation of the PALB2 Susceptibility Gene in Inherited and Sporadic Breast and Ovarian Cancer

(2008) A. Potapova et al.   CANCER RESEARCH

The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets

(2008) M. José García et al.   Clinical & Translational Oncology

A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway

(2008) Igor Landais et al.   INTERNATIONAL JOURNAL OF CANCER

Methylation status of CpG islands at sites −59 to +96 in exon 1 of the BRCA2 gene varies in mammary tissue among women with sporadic breast cancer

(2008) Nurhan Cucer et al.   JOURNAL OF GENETICS

Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin

(2008) Kyunghee Burkitt et al.   Molecular Cancer

Relevance of the Fanconi anemia pathway in the response of human cells to trabectedin

(2008) J. A. Casado et al.   MOLECULAR CANCER THERAPEUTICS

The Fanconi anemia protein interaction network: Casting a wide net

(2008) Meghan A. Rego et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS