Article
Biochemistry & Molecular Biology
Shixin Chan, Xu Wang, Zhenglin Wang, Youwen Du, Xiaomin Zuo, Jiajie Chen, Rui Sun, Qing Zhang, Li Lin, Yang Yang, Zhen Yu, Hu Zhao, Huabing Zhang, Wei Chen
Summary: This study found that CTSG expression is inhibited in colorectal cancer tissues, and patients with low CTSG expression have poor overall survival. Functional experiments showed that CTSG overexpression suppressed CRC cell progression, while CTSG suppression supported CRC development. Mechanistically, CTSG overexpression suppressed the Akt/mTOR signaling mechanism and elevated apoptotic-associated markers, while CTSG silencing activated the Akt/mTOR signaling mechanism and inhibited apoptotic-associated markers.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Lei Cao, Sang Gil Lee, Sang-Hyug Park, Hyeung-Rak Kim
Summary: Sargahydroquinoic acid can delay cellular senescence by inhibiting the Akt/mTOR signaling pathway, potentially useful for developing anti-aging therapy.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Cell Biology
Ying Liu, Dandan Wang, Mengxia Lei, Jiayi Gao, Yuqing Cui, Xiaoying Jin, Qiujie Yu, Ying Jiang, Yan Guo, Yali Liu, Li Cai, Xuesong Chen
Summary: This study revealed the inhibitory effect of GABARAP on malignant behaviors in breast cancer through the AKT/mTOR pathway. Low levels of GABARAP were associated with advanced clinicopathological features and poor prognosis of breast cancer patients.
Article
Medicine, Research & Experimental
Rattanaporn Jaidee, Veerapol Kukongviriyapan, Laddawan Senggunprai, Auemduan Prawan, Apinya Jusakul, Phatthamon Laphanuwat, Sarinya Kongpetch
Summary: Knockdown of FGFR2 suppressed cell growth and colony formation in CCA cells through G2/M cell cycle arrest and downregulation of STAT3, cyclin A, and cyclin B1. Silencing FGFR2 enhanced the suppressive effect of gemcitabine on cell migration and invasion.
Article
Environmental Sciences
Yan Song, Qiongwei Wu
Summary: This study found that OTUB2 expression was significantly upregulated in cervical squamous cell carcinoma and endocervical adenocarcinoma, and its silence attenuated the proliferative and metastatic capacities of CC cells while promoting cell apoptosis. RBM15 was also demonstrated to be upregulated in CC cells and played a role in OTUB2 upregulation through m(6)A modification, thereby promoting malignant behaviors of CC cells via the AKT/mTOR signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Danfang Wang, Jianhui Li, Wenhan Li
Summary: This study investigates the role of LHPP in gastric cancer (GC) and finds that LHPP acts as a tumor suppressor gene by inhibiting proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of GC cells. The underlying mechanism involves regulating the PI3K/AKT/mTOR pathway.
Article
Biochemistry & Molecular Biology
Chao Liu, Yun Wang, Yuyang Dao, Shuting Wang, Fei Hou, Zhixian Yang, Pengjie Liu, Juan Lv, Ling Lv, Gaofeng Li, Youjun Zhou, Zhiyong Deng
Summary: This study found that CENPM is upregulated in LUAD and promotes its progression by facilitating cell cycle progression, cell proliferation, migration, and invasion, while inhibiting cell apoptosis. CENPM also affects the growth and metastasis of LUAD by promoting the phosphorylation of mTOR.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Biotechnology & Applied Microbiology
Siou-Min Luo, Wen-Chivan Tsai, Chia-Kuang Tsai, Ying Chen, Dueng-Yuan Hueng
Summary: The study showed higher expression of ARID4B in WHO grade IV tumors, and knocking down ARID4B suppressed glioma cell proliferation and induced apoptosis, indicating that ARID4B may act as an oncogene in human gliomas.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Wen-Ya Huang, Zhi-Bin Liao, Jia-Cheng Zhang, Xin Zhang, Hong-Wei Zhang, Hui-Fang Liang, Zun-Yi Zhang, Tao Yang, Jia Yu, Ke-Shuai Dong
Summary: The study showed that TXNRD1 is upregulated in HCC tumors and correlates with poor patient survival. Functional studies demonstrated that TXNRD1 promotes HCC cell proliferation and metastasis. USF2 acts as a tumor suppressor by inhibiting TXNRD1 expression in HCC progression.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Oncology
Li-Na Zhou, Chaodong Xiong, Yong-Jun Cheng, Shan-Shan Song, Xu-Bin Bao, Xia-Juan Huan, Tong-Yan Wang, Ao Zhang, Ze-Hong Miao, Jin-Xue He
Summary: In this study, SOMCL-19-133, a highly potent and selective NAE inhibitor, was identified and found to effectively inhibit Cullin neddylation and induce DNA damage, cell cycle arrest, and apoptosis. It exhibited potent antiproliferative activity against various tumor cell lines and led to significant tumor regression in mouse xenograft models. Compared to the first-in-class NAE inhibitor MLN4924, SOMCL-19-133 showed better pharmacokinetic properties.
Article
Oncology
Luca Heinemann, Klara Maria Moellers, Helal Mohammed Mohammed Ahmed, Lanying Wei, Kaiyan Sun, Subbaiah Chary Nimmagadda, Daria Frank, Anja Baumann, Alexandra M. Poos, Martin Dugas, Julian Varghese, Marc-Steffen Raab, Cyrus Khandanpour
Summary: This study investigated the gene differences between MSCs from multiple myeloma patients and those from other diseases, showing an enrichment of the PI3K-AKT-mTOR signaling pathway in MM-associated MSCs and the inhibitory effect of Pictilisib on these cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alireza Mardanshahi, Nasrin Abbasi Gharibkandi, Samaneh Vaseghi, Seyed Mohammad Abedi, Sajjad Molavipordanjani
Summary: Radiotherapy is a common cancer treatment modality that can activate the PI3K and AKT signaling pathway to enhance tumor cell radiosensitivity. By inhibiting downstream mediators like mTOR, combined with radiation, can increase malignant cell radiosensitivity through autophagy activation.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Tianyu Dai, Junhui Liang, Wei Liu, Yonghui Zou, Feifei Niu, Mengqing Li, Haomeng Zhang, Changzhong Li, Mingjun Fan, Guoying Cui
Summary: The study found that miRNA miR-582-3p is downregulated in ovarian cancer, and knockdown of miR-582-3p promotes proliferation and migration of OC cells while overexpression inhibits their development. Long non-coding RNA TUG1 binds to miR-582-3p and plays a negative regulatory role in the progression of OC. The AKT/mTOR signaling pathway suppresses the malignant properties of OC through targeting lncRNA TUG1.
Article
Pharmacology & Pharmacy
Ziyu Liu, Yue Huang, Xin Jin, Li Liu, Hailun Gu
Summary: This study found that PCB153 is associated with the occurrence and development of osteoarthritis (OA) by activating the PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling pathways, suppressing autophagy, and promoting the degradation of the extracellular matrix of chondrocytes.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Oncology
Irene Ghobrial, Calixto Hernandez Cruz, Alfred Garfall, Nina Shah, Nikhil Munshi, Jonathan Kaufman, Lawrence H. Boise, Gareth Morgan, Viktor A. Adalsteinsson, Salomon Manier, Rathi Pillai, Fabio Malavasi, Sagar Lonial
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2019)
Article
Multidisciplinary Sciences
Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise
NATURE COMMUNICATIONS
(2019)
Review
Immunology
Benjamin G. Barwick, Vikas A. Gupta, Paula M. Vertino, Lawrence H. Boise
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Nisha S. Joseph, Jonathan L. Kaufman, Madhav Dhodapkar, Craig C. Hofmeister, Dhwani K. Almaula, Leonard T. Heffner, Vikas A. Gupta, Lawrence H. Boise, Sagar Lonial, Ajay K. Nooka
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Letter
Oncology
Roberto Mina, Nisha S. Joseph, Francesca Gay, Efstathios Kastritis, Maria Teresa Petrucci, Jonathan L. Kaufman, Vittorio Montefusco, Maria Gavriatopoulou, Francesca Patriarca, Paola Omede, Lawrence H. Boise, Maria Roussou, Nicola Giuliani, Stefania Oliva, Massimo Offidani, Angelo Belotti, David L. Jaye, Lorenzo De Paoli, Evangelos Terpos, Sagar Lonial, Mario Boccadoro, Ajay K. Nooka, Meletios A. Dimopoulos
BLOOD CANCER JOURNAL
(2020)
Article
Cell Biology
Adam Utley, Colin Chavel, Shivana Lightman, G. Aaron Holling, James Cooper, Peng Peng, Wensheng Liu, Benjamin G. Barwick, Catherine M. Gavile, Orla Maguire, Megan Murray-Dupuis, Cheryl Rozanski, Martha S. Jordan, Taku Kambayashi, Scott H. Olejniczak, Lawrence H. Boise, Kelvin P. Lee
Review
Oncology
James Ackley, Miguel Armenta Ochoa, Delta Ghoshal, Krishnendu Roy, Sagar Lonial, Lawrence H. Boise
Summary: Multiple myeloma is an incurable disease characterized by malignant plasma cells, making it a prime target for modern immune therapy. Immune therapy for multiple myeloma can be categorized into IMiDs, targeted antibodies, adoptive cell transfer therapies, and vaccines, all showing advancements in improving antitumor activity and specificity.
Editorial Material
Hematology
Timothy M. Schmidt, Lawrence H. Boise
Summary: In this study, the authors use multiomics analysis to identify a novel transcriptional network that is crucial for the poor outcomes associated with chromosome 1q amplification in multiple myeloma.
Article
Oncology
Tyler Moser-Katz, Catherine M. Gavile, Benjamin G. Barwick, Kelvin P. Lee, Lawrence H. Boise
Summary: Despite advances in multiple myeloma treatment, the disease remains incurable. This study reveals the role of CD86 cytoplasmic tail in trafficking CD86 to the cell surface and identifies SCRIB and DLG1 as important proteins for myeloma cell growth and survival.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Olayinka O. Adebayo, Eric B. Dammer, Courtney D. Dill, Adeyinka O. Adebayo, Saheed O. Oseni, Ti'ara L. Griffen, Adaugo Q. Ohandjo, Fengxia Yan, Sanjay Jain, Benjamin G. Barwick, Rajesh Singh, Lawrence H. Boise, James W. Lillard
Summary: This study investigates the molecular mechanisms underlying treatment failures in multiple myeloma using bioinformatic tools. Through gene co-expression network analysis, modules of genes associated with disease survival status were identified and crucial genes within these modules were further studied. The findings reveal the biological functions related to the risk of death in multiple myeloma, providing insights for improving treatment strategies for the disease.
Article
Medicine, Research & Experimental
Yixiang Li, Baotong Zhang, Lingwei Xiang, Siyuan Xia, Omer Kucuk, Xingming Deng, Lawrence H. Boise, Jin-Tang Dong
Article
Hematology
Yu-Hsiu T. Lin, Gregory P. Way, Benjamin G. Barwick, Margarette C. Mariano, Makeba Marcoulis, Ian D. Ferguson, Christoph Driessen, Lawrence H. Boise, Casey S. Greene, Arun P. Wiita
Article
Medicine, Research & Experimental
Jithendra Kini Bailur, Samuel S. McCachren, Deon B. Doxie, Mahesh Shrestha, Katherine Pendleton, Ajay K. Nooka, Natalia Neparidze, Terri L. Parker, Noffar Bar, Jonathan L. Kaufman, Craig C. Hofmeister, Lawrence H. Boise, Sagar Lonial, Melissa L. Kemp, Kavita M. Dhodapkar, Madhav Dhodapkar
Article
Cell Biology
Katelyn G. Ponder, Lawrence H. Boise
CELL DEATH DISCOVERY
(2019)