Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

(2013) E. Diffner et al.   BLOOD

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia

(2012) M. Luesink et al.   BLOOD

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential

(2012) A. P. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia

(2012) C. L. Carmichael et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice

(2012) L Goldberg et al.   Cell Death & Disease

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

(2011) J. A. I. Thoms et al.   BLOOD

Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

(2011) L. S. Chen et al.   BLOOD

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

(2011) S. Taoudi et al.   GENES & DEVELOPMENT

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

(2011) Christopher N Hahn et al.   NATURE GENETICS

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program

(2011) Vandana Batra et al.   PEDIATRIC BLOOD & CANCER

ERG Deregulation Induces PIM1 Over-Expression and Aneuploidy in Prostate Epithelial Cells

(2011) Vera Magistroni et al.   PLoS One

High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia

(2010) H. J. M. de Jonge et al.   BLOOD

Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos

(2010) J. M. Rowlinson et al.   BLOOD

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Salirasib in the treatment of pancreatic cancer

(2010) Ernesto Bustinza-Linares et al.   Future Oncology

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

(2010) L. Brault et al.   HAEMATOLOGICA

Association of a Leukemic Stem Cell Gene Expression Signature With Clinical Outcomes in Acute Myeloid Leukemia

(2010) Andrew J. Gentles   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients

(2010) S H Oram et al.   ONCOGENE

ERG Is a Megakaryocytic Oncogene

(2009) S. Salek-Ardakani et al.   CANCER RESEARCH

ERGExpression Is an Independent Prognostic Factor and Allows Refined Risk Stratification in Cytogenetically Normal Acute Myeloid Leukemia: A Comprehensive Analysis ofERG, MN1, andBAALCTranscript Levels Using Oligonucleotide Microarrays

(2009) Klaus H. Metzeler et al.   JOURNAL OF CLINICAL ONCOLOGY

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

(2009) Rebekka Grundler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1

(2009) Z. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

(2009) S. M. Mumenthaler et al.   MOLECULAR CANCER THERAPEUTICS

Improved prospective identification of megakaryocyte-erythrocyte progenitor cells

(2008) Michael A. Rieger et al.   BRITISH JOURNAL OF HAEMATOLOGY

Notch Signaling in Cardiac Development

(2008) Kyle Niessen et al.   CIRCULATION RESEARCH

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

(2008) Stephen J Loughran et al.   NATURE IMMUNOLOGY