Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3

Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival

(2014) Y. Kikushige et al.   JOURNAL OF IMMUNOLOGY

Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling

(2011) Saskia Gueller et al.   EXPERIMENTAL HEMATOLOGY

Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis

(2011) Chung Yeng Looi et al.   PLoS One

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

(2010) S. T. Oh et al.   BLOOD

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development

(2010) C. Boiers et al.   BLOOD

Adaptor protein Lnk inhibits c-Fms-mediated macrophage function

(2010) Saskia Gueller et al.   JOURNAL OF LEUKOCYTE BIOLOGY

LNKMutations inJAK2Mutation–Negative Erythrocytosis

(2010) Terra L. Lasho et al.   NEW ENGLAND JOURNAL OF MEDICINE

The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation

(2009) Hoang Anh Vu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation

(2009) Elena Razumovskaya et al.   EXPERIMENTAL HEMATOLOGY

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

(2009) Sigal Gery et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

(2009) Chunaram Choudhary et al.   MOLECULAR CELL

Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles

(2009) Donald Metcalf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptor protein Lnk associates with Tyr568in c-Kit

(2008) Saskia Gueller et al.   BIOCHEMICAL JOURNAL

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model

(2008) L. Li et al.   BLOOD

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells

(2008) W. F. Tam et al.   BLOOD