Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations

(2012) I. Antony-Debre et al.   BLOOD

Microtubule and cortical forces determine platelet size during vascular platelet production

(2012) Jonathan N Thon et al.   Nature Communications

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

(2012) Larissa Lordier et al.   Nature Communications

Myosin regulatory light chains are required to maintain the stability of myosin II and cellular integrity

(2011) Inju Park et al.   BIOCHEMICAL JOURNAL

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia

(2011) D. Bluteau et al.   BLOOD

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A

(2011) Y. Zhang et al.   BLOOD

Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process

(2010) L. Lordier et al.   BLOOD

RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency

(2010) G. Kaur et al.   BLOOD

Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency

(2010) G. Jalagadugula et al.   BLOOD

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice

(2010) A. ECKLY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4

(2010) K. ANEJA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9

(2009) L. Gilles et al.   BLOOD

High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder

(2009) C. Preudhomme et al.   BLOOD

Integrative analysis of RUNX1 downstream pathways and target genes

(2009) Joëlle Michaud et al.   BMC GENOMICS

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1

(2008) L. Gilles et al.   BLOOD

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation

(2008) A. Eckly et al.   BLOOD

Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes

(2008) R. Tiedt et al.   BLOOD