The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia

The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the E - TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling

(2010) M. Suljagic et al.   BLOOD

Prognosis of Binet stage A chronic lymphocytic leukemia patients: the strength of routine parameters

(2010) R. Letestu et al.   BLOOD

SYK carries no activating point mutations in patients with chronic lymphocytic leukaemia (CLL)

(2010) Angela Philippen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Activities of SYK and PLC 2 Predict Apoptotic Response of CLL Cells to SRC Tyrosine Kinase Inhibitor Dasatinib

(2010) Z. Song et al.   CLINICAL CANCER RESEARCH

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

(2009) J. W. Friedberg et al.   BLOOD

Down-regulation of CXCR4 and CD62L in Chronic Lymphocytic Leukemia Cells Is Triggered by B-Cell Receptor Ligation and Associated with Progressive Disease

(2009) A. Vlad et al.   CANCER RESEARCH

Spleen Tyrosine Kinase Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia

(2009) Maike Buchner et al.   CANCER RESEARCH

Phosphorylation of the activation loop tyrosines is required for sustained Syk signaling and growth factor-independent B-cell proliferation

(2009) Laura Carsetti et al.   CELLULAR SIGNALLING

Molecular and cellular mechanisms of CLL: novel therapeutic approaches

(2009) Lisa Pleyer et al.   Nature Reviews Clinical Oncology

The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCδ and proteasome-dependent regulation of Mcl-1 expression

(2009) A D Baudot et al.   ONCOGENE

Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

(2008) M. Muzio et al.   BLOOD

CD20 Homo-oligomers Physically Associate with the B Cell Antigen Receptor

(2008) Maria J. Polyak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

(2008) S Gobessi et al.   LEUKEMIA

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

(2007) P. G. Longo et al.   BLOOD