Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies

The miR-17-92 MicroRNA Cluster Is Regulated by Multiple Mechanisms in B-Cell Malignancies

(2011) Ming Ji et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel proteasome-inhibitory syrbactin analogs inducing endoplasmic reticulum stress and apoptosis in hematological tumor cell lines

(2011) Ashish Anshu et al.   BIOCHEMICAL PHARMACOLOGY

Cytoplasmic CUL9/PARC Ubiquitin Ligase Is a Tumor Suppressor and Promotes p53-Dependent Apoptosis

(2011) X.-H. Pei et al.   CANCER RESEARCH

Ubiquitin-mediated protein degradation and methylation-induced gene silencing cooperate in the inactivation of the INK4/ARF locus in Burkitt lymphoma cell lines

(2011) Annalisa Roberti et al.   CELL CYCLE

Association of a MicroRNA/TP53 Feedback Circuitry With Pathogenesis and Outcome of B-Cell Chronic Lymphocytic Leukemia

(2011) Muller Fabbri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Eμ/miR-125b transgenic mice develop lethal B-cell malignancies

(2011) Y Enomoto et al.   LEUKEMIA

Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21)

(2011) E Drakos et al.   LEUKEMIA

A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples

(2011) Sona Pekova et al.   LEUKEMIA RESEARCH

Cooperative Role of the RNA-Binding Proteins Hzf and HuR in p53 Activation

(2011) H. Nakamura et al.   MOLECULAR AND CELLULAR BIOLOGY

Redox modulation of p53: Mechanisms and functional significance

(2011) Do-Hee Kim et al.   MOLECULAR CARCINOGENESIS

Association with TP53 codon 72 polymorphism and the risk of non-Hodgkin lymphoma

(2010) Hee Nam Kim et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells

(2010) Fei Wang et al.   APOPTOSIS

MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3′ untranslated region

(2010) Shu Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network

(2010) Lakshmanane Boominathan   CANCER AND METASTASIS REVIEWS

Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

(2010) Flavia Pichiorri et al.   CANCER CELL

Functional characterization of p53β and p53γ, two isoforms of the tumor suppressor p53

(2010) Vilma Graupner et al.   CELL CYCLE

Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia

(2010) Olaf Merkel et al.   CELL CYCLE

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

(2010) Hussein A. Abbas et al.   Cell Stem Cell

MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell States

(2010) Pierre Neveu et al.   Cell Stem Cell

MicroRNA-34a Perturbs B Lymphocyte Development by Repressing the Forkhead Box Transcription Factor Foxp1

(2010) Dinesh S. Rao et al.   IMMUNITY

Pathogenesis of diffuse large B cell lymphoma

(2010) Wing (John) C. Chan   INTERNATIONAL JOURNAL OF HEMATOLOGY

Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity

(2010) M. Ahmad Chaudhry et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells

(2010) Jonathan L. Coloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of tumor suppressor p53 at the RNA level

(2010) Anna Vilborg et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

p53 and autophagy contribute to dasatinib resistance in primary CLL lymphocytes

(2010) Lilian Amrein et al.   LEUKEMIA RESEARCH

Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504

(2010) Wenwei Hu et al.   MOLECULAR CELL

ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia

(2010) S H Tonino et al.   ONCOGENE

Negative regulation of the tumor suppressor p53 gene by microRNAs

(2010) M Kumar et al.   ONCOGENE

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

(2010) Chew Hooi Wong et al.   PLoS One

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia

(2009) Y. Yamanaka et al.   BLOOD

Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML

(2009) Kensuke Kojima et al.   CANCER SCIENCE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Regulation of p53 - insights into a complex process

(2009) Karen A Boehme et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

p53 ubiquitination by Mdm2: A never ending tail?

(2009) Amanda S. Coutts et al.   DNA REPAIR

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

(2009) Hong-li Yan et al.   EMBO JOURNAL

MicroRNA-125b is a novel negative regulator of p53

(2009) M. T.N. Le et al.   GENES & DEVELOPMENT

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

(2009) Li-Fan Lu et al.   IMMUNITY

Redox-Dependent Translocation of p53 to Mitochondria or Nucleus in Human Melanocytes after UVA- and UVB-Induced Apoptosis

(2009) Petra K. Wäster et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Massively regulated genes: the example ofTP53

(2009) Monica Hollstein et al.   JOURNAL OF PATHOLOGY

Molecular targeted therapies for diffuse large B-cell lymphoma based on apoptosis profiles

(2009) Saskia AGM Cillessen et al.   JOURNAL OF PATHOLOGY

The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53

(2009) E Drakos et al.   LEUKEMIA

MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes

(2009) Marek Mraz et al.   LEUKEMIA & LYMPHOMA

Effect of autophagy on multiple myeloma cell viability

(2009) B. Hoang et al.   MOLECULAR CANCER THERAPEUTICS

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations

(2009) Davide F. Robbiani et al.   MOLECULAR CELL

Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer

(2009) B Y Ahn et al.   ONCOGENE

p53 and little brother p53/47: linking IRES activities with protein functions

(2009) R Grover et al.   ONCOGENE

Transcription activity is required for p53-dependent tumor suppression

(2009) O Gaidarenko et al.   ONCOGENE

p53-dependent senescence delays Eμ-myc-induced B-cell lymphomagenesis

(2009) S M Post et al.   ONCOGENE

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas

(2008) R. Malumbres et al.   BLOOD

MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas

(2008) Anja Roehle et al.   BRITISH JOURNAL OF HAEMATOLOGY

Integrating Global Gene Expression and Radiation Survival Parameters across the 60 Cell Lines of the National Cancer Institute Anticancer Drug Screen

(2008) S. A. Amundson et al.   CANCER RESEARCH

Combination treatment with arsenic trioxide and irradiation enhances apoptotic effects in U937 cells through increased mitotic arrest and ROS generation

(2008) Sheng-Yow Ho et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Expression of microRNAs in diffuse large B cell lymphoma is associated with immunophenotype, survival and transformation from follicular lymphoma

(2008) Charles H. Lawrie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA

p53 mRNA controls p53 activity by managing Mdm2 functions

(2008) Marco M. Candeias et al.   NATURE CELL BIOLOGY

MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

(2008) F. Pichiorri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel, transactivation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia

(2007) Sona Pekova et al.   LEUKEMIA RESEARCH