Article
Biochemistry & Molecular Biology
Mark S. Rybchyn, Tara Clare Brennan-Speranza, David Mor, Zhiqiang Cheng, Wenhan Chang, Arthur D. Conigrave, Rebecca S. Mason
Summary: The study demonstrates a relationship between CaSR and Homer1 in human osteoblasts, where inhibiting one protein affects the expression level of the other. Further investigation shows that bone cells from CaSR-/- mice exhibit increased Homer1 expression and altered subcellular localization compared to wild-type mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jessica Guenzle, Harue Akasaka, Katharina Joechle, Wilfried Reichardt, Aina Venkatasamy, Jens Hoeppner, Claus Hellerbrand, Stefan Fichtner-Feigl, Sven A. Lang
Summary: This study demonstrates the significant reduction in migration, invasion, and proliferation of melanoma cells upon specific inhibition of mTORC2 using the novel inhibitor JR-AB2-011, leading to cell death through non-apoptotic pathways. In a syngeneic murine metastasis model, therapy with JR-AB2-011 showed a remarkable decrease in liver metastasis, highlighting the potential of pharmacological blockade of mTORC2 as a novel anti-cancer approach for melanoma liver metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ramya Nair, Alejandro Salinas-Illarena, Hanna-Mari Baldauf
Summary: The treatment of acute myeloid leukemia (AML) is challenging due to its heterogeneity, leading to a shift towards personalized treatment based on genomic signature. Novel insights into AML survival pathways, including drug resistance and immune system evasion, are being revealed. The combination of drugs or treatments has shown enhanced clinical efficiencies, prompting further investigation into targeted pathways for increased treatment response.
Article
Biochemistry & Molecular Biology
Jin Hwa Cho, Kidae Kim, Sung Ah Kim, Sungryul Park, Bi-Oh Park, Jong-Hwan Kim, Seon-Young Kim, Min Jee Kwon, Myeong Hoon Han, Sung Bae Lee, Byoung Chul Park, Sung Goo Park, Jeong-Hoon Kim, Sunhong Kim
Summary: OTUD5 has been identified as a novel positive regulator of the mTOR complex signaling pathways, playing a role in stabilizing specific proteins to degrade the inhibitory protein DEPTOR of mTOR, affecting physiological phenotypes such as cell size and autophagy. Our results suggest a positive feedback loop between OTUD5 and the mTOR signaling pathway.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Hematology
Freda K. Stevenson, Francesco Forconi, Thomas J. Kipps
Summary: Research into chronic lymphocytic leukemia has led to significant improvements in the assessment and treatment of patients, with designer drugs now successfully targeting tumor cells based on their biology. Classifying CLL into unmutated (U) and mutated (M) diseases based on the mutational status of IGHV sequences reveals distinct origins, biology, and clinical behaviors for each. Despite advances, challenges such as cell-escape strategies and immunosuppression remain, necessitating continued research into CLL biology.
Review
Biochemistry & Molecular Biology
Anna G. Mankovich, Brian C. Freeman
Summary: Heat shock protein 90 (Hsp90), a highly conserved molecular chaperone, not only maintains the stability of metastable proteins, but also plays a crucial role in protein transport. The specific contributions of Hsp90 to protein transport are still not well defined, despite numerous connections with factors involved in this process.
Review
Behavioral Sciences
Camilla L. Nord, Sarah N. Gar
Summary: The recognition of the dynamic coupling between the brain and body has enhanced our understanding of mental health conditions. Disruptions to the interoceptive system may contribute to anxiety, depression, and psychosis. This review examines the nature of interoceptive disturbances in mental health conditions and explores the interoceptive pathways of existing and potential treatments.
TRENDS IN COGNITIVE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Hongbo Ma, Shengming Liu, Shanrui Li, Yong Xia
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown origin, which currently lacks ideal treatment options. Although some drugs have been approved for the treatment of IPF, they have limitations. Therefore, research on cytokine and growth factor pathways is important for identifying more effective therapeutic targets to improve the prognosis and quality of life for IPF patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Weitong Xu, Tingting Zhao, Honghan Chen, Ning Huang, Hui Gong, Jian Zhang, Yu Yang, Tiepeng Li, Gongchang Zhang, Chuhui Gong, Ming Yang, Hengyi Xiao
Summary: This study reveals the sensitization effect of pan-mTOR inhibitors on navitoclax-induced senolytic apoptosis, providing novel evidence for the advantage of drug combination in senotherapy and demonstrating the value of mTORC2 inhibition for apoptotic death of senescent cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chanichon Chomchoei, James Michael Brimson, Sirikalaya Brimson
Summary: Childhood cancer has a low cure rate in low-income countries, and a cheaper treatment option is needed. Fluoxetine, a well-tested drug, may be effective in treating acute leukemia by targeting the sigma-1 receptor.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Review
Cell Biology
Kamau M. M. Fahie, Kyriakos N. Papanicolaou, Natasha E. Zachara
Summary: The modification of proteins by O-GlcNAc is an essential post-translational modification that plays a key role in cellular stress response, particularly in the cardiovascular system and neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Yingji Chen, Dongyue Jiao, Huiying He, Huiru Sun, Yajuan Liu, Qing Shi, Pingzhao Zhang, Yao Li, Ren Mo, Kun Gao, Chenji Wang
Summary: This study demonstrates that Keap1 regulates the activity and integrity of mTORC2 by binding to mLST8. Cancer-associated mutations in Keap1 or mLST8 disrupt their interaction, enhancing mTORC2-AKT activation and promoting cell malignancy and remodeling of cell metabolism.
Review
Oncology
Carol Moreno, Cecilia Munoz, Maria Jose Terol, Jose-Angel Hernandez-Rivas, Miguel Villanueva
Summary: Chronic Lymphocytic Leukemia is a hematological malignancy characterized by uncontrolled B-cell proliferation and severe immune dysfunction. Developing therapeutic strategies that target both malignant B-cells and enhance the patient's immune response could be clinically relevant in treating CLL patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Xiayinan Song, Xiaoming Wang, Danyang Wang, Zhenzhen Zheng, Jie Li, Yunlun Li
Summary: This article reviews the potential targets for inflammation against atherosclerosis, discusses the underlying mechanisms of natural drugs for treating atherosclerosis, particularly highlights the current research dilemma, and ultimately provides perspectives in this field.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Indira Singaram, Ashutosh Sharma, Shashank Pant, Muyun Lihan, Mi-Jeong Park, Melissa Pergande, Pawanthi Buwaneka, Yusi Hu, Nadim Mahmud, You-Me Kim, Stephanie Cologna, Vladimir Gevorgyan, Irum Khan, Emad Tajkhorshid, Wonhwa Cho
Summary: Membrane lipids control the cellular activity of kinases containing the SH2 domain. In this study, new nonlipidic small molecule inhibitors of the lipid-SH2 domain interaction were developed to block the cellular activity of their host proteins. The research shows that targeting lipid-protein interaction is a powerful approach to developing new small molecule drugs.
NATURE CHEMICAL BIOLOGY
(2023)