Journal
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
Volume 93, Issue 9, Pages 1398-1401Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.12945
Keywords
acute myeloid leukemia; NUP98; translocation partners
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Funding
- FIRC (Fondazione Italiana Ricerca sul Cancro)
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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In a case of acute myeloid leukemia we report molecular cytogenetic findings of a t(3;11)(q12;p15), characterized as a new NUP98 translocation rearranging with LOC348801 at chromosome 3. NUP98 involvement was detected by fluorescence in situ hybridization. 3'-RACE-PCR showed nucleotide 1718 (exon 13) of NUP98 was fused in-frame with nucleotide 1248 (exon 2) of LOC348801. RT-PCR and cloning experiments detected two in-frame spliced NUP98-LOC348801 transcripts and the reciprocal LOC348801-NUP98. A highly specific double-color double-fusion FISH assay reliably detects NUP98-LOC348801.
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