Inherited defects in lymphocyte cytotoxic activity

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A concanavalin A-like lectin domain in the CHS1/LYST protein, shared by members of the BEACH family

(2009) Agathe Burgess et al.   BIOINFORMATICS

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

(2009) S. M. Wood et al.   BLOOD

Neutralization of IFNγ defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice

(2009) Jana Pachlopnik Schmid et al.   EMBO Molecular Medicine

Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain

(2009) Allison M. Beal et al.   IMMUNITY

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

(2009) Misty R. Jenkins et al.   IMMUNITY

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

(2009) J. Chia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perforin-mediated suppression of B-cell lymphoma

(2009) Paul Bolitho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

(2008) G. Menasche et al.   BLOOD

Syntaxin-11 is expressed in primary human monocytesmacrophages and acts as a negative regulator of macrophage engulfment of apoptotic cells and IgG-opsonized target cells

(2008) Shouting Zhang et al.   BRITISH JOURNAL OF HAEMATOLOGY

Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

(2008) Denis Martinvalet et al.   CELL

A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH)

(2008) Jana Pachlopnik Schmid et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An immunoblotting assay to facilitate the molecular diagnosis of Hermansky–Pudlak syndrome

(2008) Ramin Nazarian et al.   MOLECULAR GENETICS AND METABOLISM

Mechanisms of membrane fusion: disparate players and common principles

(2008) Sascha Martens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse

(2008) Oliver Holt et al.   TRAFFIC