Article
Cell Biology
Mariana V. Rosemblatt, Brian Parra-Tello, Pedro Briceno, Elizabeth Rivas-Yanez, Suat Tucer, Juan Saavedra-Almarza, Pilar Hormann, Brandon A. Martinez, Alvaro Lladser, Mario Rosemblatt, Caglar Cekic, Maria Rosa Bono, Daniela Sauma
Summary: This study assessed the impact of CD73 deficiency on CD8+ T cells and found that CD73 has a dual effect, favoring homeostatic survival but reducing survival under antigenic stimulation. Special attention should be given to these aspects when considering CD73 blockade in the design of novel antitumor therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ruriko Suzuki, Yoshikazu Inoh, Satoru Yokawa, Tadahide Furuno, Naohide Hirashima
Summary: Aggregation of IgE bound to Fc epsilon RI induces mast cell activation, while disaggregation by monomer hapten terminates degranulation. Actin polymerization is involved in this process, with multivalent antigens depolymerizing actin filaments and monomer haptens recovering actin polymerization. Cofilin phosphorylation plays a key role in actin rearrangement and polymerization in mast cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Jake R. Thomas, Anna Appios, Xiaohui Zhao, Roksana Dutkiewicz, Maria Donde, Colin Y. C. Lee, Praveena Naidu, Christopher Lee, Joana Cerveira, Bing Liu, Florent Ginhoux, Graham Burton, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Naomi McGovern
Summary: Hofbauer cells are an important immune cell population found in the placenta, involved in placental angiogenesis and remodeling. Additionally, there is another population of maternal macrophages in the placenta that aid in surface repair.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Darine W. El-Naccache, Fei Chen, Mark J. Palma, Alexander Lemenze, Matthew A. Fischer, Wenhui Wu, Pankaj K. Mishra, Holger K. Eltzschig, Simon C. Robson, Francesco Di Virgilio, George S. Yap, Karen L. Edelblum, Gyorgy Hasko, William C. Gause
Summary: Intestinal nematode parasites can cause tissue damage and promote host protective type 2 immunity by crossing the epithelial barrier and releasing danger-associated molecular patterns. The A2B adenosine receptor on intestinal epithelial cells plays an important role in this process. Blocking this receptor inhibits the host protective memory response to the parasite, affecting granuloma development at the host-parasite interface.
Article
Immunology
Tongqian Wu, Shirong Yan, Yu-Wen Yeh, Yu Fang, Zou Xiang
Summary: This study found that mast cells expressing only FcγRIIB or FcγRIIIA undergo caspase-independent apoptosis in response to IgG immune complex treatment. Lower frequencies of connective tissue mast cells (CTMC) were recorded in mice lacking either FcγRIIB or FcγRIIIA compared with wild-type mice, especially in aged mice. This suggests that FcγR-mediated mast cell apoptosis may explain the more robust persistence of CTMC compared to mucosal mast cells (MMC). The results were replicated in a mast cell engraftment model, ruling out possible confounding effects of mast cell recruitment or FcγR expression by other cells on mast cell number regulation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Cell Biology
Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bank G. Fenyves, Nicole C. Charland, Anna L. K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas J. LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, Kasidet Manakongtreecheep, Justin D. Margolin, Brenna N. McKaig, Maricarmen Rojas-Lopez, Brian C. Russo, Nihaarika Sharma, Jessica Tantivit, Molly F. Thomas, Robert E. Gerszten, Graham S. Heimberg, Paul J. Hoover, David J. Lieb, Brian Lin, Debby Ngo, Karin Pelka, Miguel Reyes, Christopher S. Smillie, Avinash Waghray, Thomas E. Wood, Amanda S. Zajac, Lori L. Jennings, Ida Grundberg, Roby P. Bhattacharyya, Blair Alden Parry, Alexandra-Chloe Villani, Moshe Sade-Feldman, Nir Hacohen, Marcia B. Goldberg
Summary: This study analyzed thousands of plasma proteins longitudinally in COVID-19 patients, uncovering immune and non-immune proteins linked to the disease. Dynamic immune-cell-derived and tissue-associated proteins associated with survival were identified. The research proposed a model in which interactions among myeloid, epithelial, and T cells drive tissue damage in severe COVID-19 disease.
CELL REPORTS MEDICINE
(2021)
Article
Multidisciplinary Sciences
Denise Beckmann, Anja Roemer-Hillmann, Annika Krause, Uwe Hansen, Corinna Wehmeyer, Johanna Intemann, David J. J. de Gorter, Berno Dankbar, Jan Hillen, Marianne Heitzmann, Isabell Begemann, Milos Galic, Toni Weinhage, Dirk Foell, Rizi Ai, Joachim Kremerskothen, Hans P. Kiener, Sylvia Mueller, Thomas Kamradt, Christopher Schroeder, Elsa Leitao, Bernhard Horsthemke, Philip Rosenstiel, Karl Nordstroem, Gilles Gasparoni, Nina Gasparoni, Jorn Walter, Na Li, Xinyi Yang, Ho-Ryun Chung, Hermann Pavenstaedt, Nico Lindemann, Hans J. Schnittler, Wei Wang, Gary S. Firestein, Thomas Pap, Adelheid Korb-Pap
Summary: The study identifies Lasp1 as epigenetically regulated and highly expressed in fibroblast-like synoviocytes in rheumatoid arthritis, and deletion of Lasp1 can limit joint pathology in a mouse model of inflammatory arthritis. This suggests that Lasp1 may be a potential target for treating inflammatory joint disorders associated with aggressive cellular transformation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Carla E. Cadena del Castillo, J. Thomas Hannich, Andres Kaech, Hirohisa Chiyoda, Jonathan Brewer, Masamitsu Fukuyama, Nils J. Faergeman, Howard Riezman, Anne Spang
Summary: The study reveals that the hedgehog signaling receptor PTCH functions as a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, resulting in changes in nuclear hormone receptor activity and fatty acid metabolism. This sheds light on the role of PTCH in maintaining organelle structure and fat metabolism.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Sultan Alanazi, Fabio Rabelo Melo, Gunnar Pejler
Summary: This study reveals the significant role of tryptase in core histone processing and epigenetic modification in human mast cell leukemia cells, where inhibition of tryptase can reverse the effects of cell death on these modifications. The presence of tryptase in the nucleus suggests its involvement in regulating nuclear events and controlling cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Marcel S. Woo, Friederike Ufer, Jana K. Sonner, Anouar Belkacemi, Joseph Tintelnot, Pablo J. Saez, Paula F. Krieg, Christina Mayer, Lars Binkle-Ladisch, Jan Broder Engler, Simone Bauer, Nina Kursawe, Vanessa Vieira, Stefanie Mannebach, Marc Freichel, Veit Flockerzi, Pablo Vargas, Manuel A. Friese
Summary: The study identifies CACNB3 as a master regulator of ATP-dependent migDC migration, which plays a crucial role in regulating tissue-specific immune responses during injury and inflammation.
Article
Multidisciplinary Sciences
Sook-Kyoung Heo, Ho-Min Yu, Do Kyoung Kim, Hye Jin Seo, Yerang Shin, Sung Ah Kim, Minhui Kim, Youjin Kim, Yoo Jin Lee, Eui-Kyu Noh, Jae-Cheol Jo
Summary: Liver transplantation is the most effective treatment option for patients with liver failure, but there are limitations such as donor shortage, complications, high costs, and the need for immunosuppressive therapy. An alternative approach is liver cell transplantation. This study investigated the effect of a protein called LIGHT on the differentiation of human bone marrow-derived stem cells into liver-like cells.
Review
Biochemistry & Molecular Biology
Sharmila Govindaraj, Lakshmi Bhargavi Paruchuru, Ehud Razin
Summary: The innate and adaptive immune systems are essential in host defense against pathogens, with mast cells playing a central role by releasing inflammatory mediators involved in various inflammatory and allergic diseases. The discovery of the pLysRS-Ap(4)A signaling pathway in mast cells is a significant step towards understanding the intracellular mechanisms of mast cell activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Diego R. Coelho, Flavio R. Palma, Veronica Paviani, Katy M. LaFond, Yunping Huang, Dongmei Wang, Brian Wray, Sridhar Rao, Feng Yue, Marcelo G. Bonini, Benjamin N. Gantner
Summary: Suppressor of cytokine signaling-1 (SOCS1) controls inflammation by degrading p65 NF-κB in addition to its canonical role. However, SOCS1 selectively targets a subset of pro-inflammatory genes. The interaction between SOCS1 and p65 at promoters determines the genes activated by NF-κB during systemic inflammation, leading to significant effects on cytokine responses, immune cell mobilization, and tissue injury.
Article
Biology
A. K. M. Nur-ur Rahman, Jun Liu, Shariq Mujib, Segen Kidane, Arman Ali, Steven Szep, Carrie Han, Phil Bonner, Michael Parsons, Erika Benko, Colin Kovacs, Feng Yun Yue, Mario Ostrowski
Summary: The exhaustion of HIV-specific CD8(+) T cells is characterized by reduced glycolytic activity, enhanced OXPHOS demands, dysregulated mTOR, and reduced cytoplasmic GAPDH content. These changes may contribute to CD8(+) T-cell dysfunction in HIV.
LIFE SCIENCE ALLIANCE
(2021)
Article
Multidisciplinary Sciences
Alicia Sanchez-Sanz, Maria Posada-Ayala, Julia Sabin-Munoz, Ismael Fernandez-Miranda, Yolanda Aladro-Benito, Roberto Alvarez-Lafuente, Ana Royuela, Ruth Garcia-Hernandez, Ofir Rodriguez-De la Fuente, Julian Romero, Antonio Garcia-Merino, Antonio Jose Sanchez-Lopez
Summary: The endocannabinoid system (ECS) is dysregulated in multiple sclerosis (MS) patients, and dimethyl fumarate (DMF) may potentially modulate the ECS to exert its therapeutic effects.
SCIENTIFIC REPORTS
(2022)