Article
Pediatrics
Madeleine Ernst, Simon Rogers, Ulrik Lausten-Thomsen, Anders Bjorkbom, Susan Svane Laursen, Julie Courraud, Anders Borglum, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, David M. Hougaard, Arieh S. Cohen
Summary: This study utilized metabolomics tools to measure over 9000 metabolites in 298 neonatal blood samples, identifying approximately 16% of metabolites significantly correlated with gestational age. Eighty-three metabolites explained 48% of the variance in gestational age, revealing the age-dependent development of the neonatal blood metabolome.
PEDIATRIC RESEARCH
(2021)
Article
Environmental Sciences
Weili Yang, Joseph M. Braun, Ann M. Vuong, Zana Percy, Yingying Xu, Changchun Xie, Ranjan Deka, Antonia M. Calafat, Maria Ospina, Heather H. Burris, Kimberly Yolton, Kim M. Cecil, Bruce P. Lanphear, Aimin Chen
Summary: Organophosphate esters (OPEs) have been found to be developmental toxicants in animal studies, but limited evidence is available in humans. This study investigated the association between gestational exposure to OPEs and gestational age, preterm birth, and newborn anthropometric measures. The findings suggest that certain OPEs may be associated with these outcomes, with some associations being specific to certain time windows and infant sex.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, General & Internal
Ethan K. Gough, Thaddeus J. Edens, Hyun Min Geum, Iman Baharmand, Sandeep K. Gill, Ruairi C. Robertson, Kuda Mutasa, Robert Ntozini, Laura E. Smith, Bernard Chasekwa, Florence D. Majo, Naume Tavengwa, Batsirai Mutasa, Freddy Francis, Lynnea Carr, Joice Tome, Rebecca J. Stoltzfus, Lawrence H. Moulton, Andrew J. Prendergast, Jean H. Humphrey, Amee R. Manges
Summary: The study in rural Zimbabwe found that the maternal intestinal microbiome composition and functions during pregnancy are closely related to infant birth weight and growth outcomes, with resistant starch-degrading bacteria playing a key role in predicting birth outcomes.
Article
Obstetrics & Gynecology
Tianchu Lyu, Chen Liang, Jihong Liu, Peiyin Hung, Jiajia Zhang, Berry Campbell, Nadia Ghumman, Bankole Olatosi, Neset Hikmet, Manting Zhang, Honggang Yi, Xiaoming Li
Summary: Pregnant individuals infected with SARS-CoV-2 during early and midpregnancy have an increased risk of stillbirth, while there is no such risk when infected before delivery or during the third trimester. This suggests the potential vulnerability of the fetus to SARS-CoV-2 infection in early pregnancy and underscores the importance of proactive COVID-19 prevention and timely medical intervention for individuals infected during early and midpregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pediatrics
Joachim Hartmann, Maria Munk Paerregaard, Jakob Norsk, Adrian Pietersen, Kasper Karmark Iversen, Henning Bundgaard, Alex Horby Christensen
Summary: The study found significant impact of gestational age on neonatal ECG parameters, with boys showing longer PR and QRS intervals and a more right-shifted QRS axis. Gestational age was directly associated with the development of the neonatal cardiac conduction system, and the use of GA-specific reference values can optimize clinical management.
Article
Acoustics
S. Ruiz-Martinez, J. L. Delgado, C. Paules, A. Cavallaro, C. De Paco, J. Villar, A. Papageorghiou, D. Oros
Summary: This study identified nine clinical phenotypes of small-for-gestational-age (SGA) fetuses that are associated with different patterns of adverse perinatal outcomes. The findings suggest that considering clinical characteristics in addition to ultrasound findings could improve risk stratification and decision-making for managing SGA fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Eric O. Ohuma, Chia-Jung Chang, Elizabeth A. Hazel, Judith Yargawa, Yemisrach B. Okwaraji, Ellen Bradley, Adrienne Gordon, Jessica Sexton, Harriet L. S. Lawford, Enny S. Paixao, Ila R. Falcao, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik T. Sorensen, Luule Sakkeus, Lili Abuladze, Khalid A. Yunis, Ayah Al Bizri, Sonia Lopez Alvarez, Lisa Broeders, Aimee E. van Dijk, Fawziya Alyafei, Mai Alqubaisi, Neda Razaz, Jonas Soederling, Lucy K. Smith, Ruth J. Matthews, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Joy E. Lawn, Hannah Blencowe
Summary: In this study, the prevalence and neonatal mortality of large for gestational age (LGA) and macrosomia were compared among live births in 15 countries. The results showed that LGA babies had a lower risk of neonatal mortality compared to babies that were appropriate for gestational age (AGA), while macrosomia babies weighing over 4500 grams had a higher risk of mortality.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Stephen Contag, Rahel Nardos, Irina A. Buhimschi, Jennifer Almanza
Summary: A study in Minnesota found that Somali women have longer gestational ages at delivery compared to other ethnic groups, resulting in higher risks for stillbirth and neonatal death rates. However, at 42 weeks, Somali neonatal mortality decreased and was comparable to that of the U.S. born White population, and lower than that of other minorities.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Ipek Gurol-Urganci, Jennifer Jardine, Fran Carroll, Alissa Fremeaux, Patrick Muller, Sophie Relph, Lara Waite, Kirstin Webster, Sam Oddie, Jane Hawdon, Tina Harris, Asma Khalil, Jan van Der Meulen
Summary: This study assessed the association between hospital-level rates of induction of labour and emergency caesarean section, as measures of 'practice style', and rates of adverse perinatal outcomes. The results showed that women who gave birth in hospitals with a higher rate of induction of labour had better perinatal outcomes, while there was no significant association between hospital-level rates of emergency caesarean section and adverse perinatal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Ira Hamilton, Nicole Martin, James Liu, Emily DeFranco, Robert Rossi
Summary: The study aims to determine the optimal timing of delivery for pregnancies conceived with infertility treatment. The results suggest that delivery at 39 weeks provides the lowest perinatal risk in this population.
Article
Health Care Sciences & Services
Junjun Chen, Yuelong Ji, Tao Su, Ma Jin, Zhichao Yuan, Yuanzhou Peng, Shuang Zhou, Heling Bao, Shusheng Luo, Hui Wang, Jue Liu, Na Han, Hai-Jun Wang
Summary: Prediction models developed through machine learning statistics can help identify high-risk patients with de novo hypertensive disorder of pregnancy, enabling timely intervention and care.
Article
Endocrinology & Metabolism
Yongfu Yu, Melissa Soohoo, Henrik Toft Sorensen, Jiong Li, Onyebuchi A. Arah
Summary: Gestational diabetes mellitus is associated with increased risks of cardiovascular diseases, particularly among women with a history of GDM. This association is partly explained by the development of type 2 diabetes, but other pathways should also be explored.
Article
Medicine, General & Internal
Joseph Phillipos, Thao Vi Luong, Deborah Chang, Suresh Varadarajan, Paul Howat, Lauren Hodgson, Deb Colville, Judy Savige
Summary: The study compared the effects of gestational diabetes, pregnancy-associated hypertension, and small-for-gestational age babies on systemic small vessel calibre examined in the retina. Results showed that women with gestational diabetes, pregnancy-associated hypertension, or small-for-gestational age babies had reduced mean retinal arterial calibre, with the greatest reduction seen in pregnancy-associated hypertension and small-for-gestational age babies.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Rebecca Stone, Kirsten Palmer, Euan M. Wallace, Mary-Ann Davey, Ryan Hodges, Miranda Davies-Tuck
Summary: Early monitoring of South Asian pregnancies from 39 weeks' gestation with AFI and CTG can help identify potential fetal compromise earlier and trigger intervention to prevent perinatal issues.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Selina Nath, Pia Hardelid, Ania Zylbersztejn
Summary: The infant mortality rate in England decreased from 2006 to 2014 but started to increase again from 2014 to 2016, driven by an increase in deaths at 0-6 days of age. Excluding infants born at <24 weeks of gestation, the mortality rate continued to decrease after 2014. The risk of infant death was 94% higher in the most deprived SES quintile compared to the least deprived, which reduced to 55% higher after adjusting for gestational age.
JOURNAL OF PUBLIC HEALTH
(2021)
Editorial Material
Public, Environmental & Occupational Health
Sarka Lisonkova, K. S. Joseph
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sarka Lisonkova, Jeffrey N. Bone, Giulia M. Muraca, Neda Razaz, Amelie Boutin, Justin S. Brandt, Mohamed A. Bedaiwy, Cande Ananth, K. S. Joseph
Summary: The closure of ART clinics during the early pandemic resulted in a significant decline in ART-conceived live births and multiple births, as well as an increase in stillbirths among ART-conceived births. Women who conceived during the early pandemic period also had a higher prevalence of obesity and chronic hypertension.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Acoustics
A. Arechvo, A. Wright, A. Syngelaki, P. von Dadelszen, L. A. Magee, R. Akolekar, D. Wright, K. H. Nicolaides
Summary: This study aimed to investigate the relationship between the English Index of Multiple Deprivation (IMD) and the incidence of pre-eclampsia (PE), assess the distribution of IMD in a diverse cohort of pregnant women, and evaluate whether IMD improves the prediction of PE compared to a "history-only" competing-risks model. The results showed that the incidence of PE increased across IMD quintiles, and black women had a higher incidence of PE. However, IMD did not improve the prediction of PE compared to race and other maternal characteristics.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Peter von Dadelszen, Argyro Syngelaki, Ranjit Akolekar, Laura A. Magee, Kypros H. Nicolaides
Summary: This study aimed to compare the relative burdens of maternal and perinatal complications for preterm and term pre-eclampsia. A prospective observational cohort study was conducted in two English maternity units, including unselected women with singleton pregnancies who developed pre-eclampsia. The results showed that preterm pre-eclampsia was more likely to lead to adverse maternal and perinatal events; however, the majority of maternal complications and a significant proportion of perinatal complications still occurred in women with term pre-eclampsia. Therefore, efforts should be made to reduce the incidence of term pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Lauren Yearwood, Jeffrey N. Bone, Qi Wen, Giulia M. Muraca, Janet Lyons, Neda Razaz, K. S. Joseph, Sarka Lisonkova
Summary: Maternal stature affects the status of Small for Gestational Age (SGA) and Large for Gestational Age (LGA) at birth and neonatal outcomes. Quantifying this risk can assist healthcare providers in monitoring fetal growth and optimizing neonatal care and follow-up.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ugochinyere Vivian Ukah, Robert W. Platt, Nathalie Auger, Sarka Lisonkova, Joel G. Ray, Isabelle Malhame, Aimina Ayoub, Darine El-Chaar, Natalie Dayan
Summary: Women who have experienced severe maternal morbidity have a relatively high risk of recurrent morbidity in the subsequent pregnancy, especially if multiple types of severe maternal morbidity occurred in their first delivery. Women with cardiac complications during their first delivery have the highest risk of severe maternal morbidity in the next delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Hannah Blencowe, Yemisrach B. Okwaraji, Judith Yargawa, Ellen Bradley, Adrienne Gordon, Vicki S. Flenady, Enny L. Paixao, Mauricio Barreto, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik Toft Sorensen, Luule Sakkeus, Liili A. Abuladze, Khalid Yunis, Ayah Al Bizri, Arturo Barranco, Lisa Broeders, Aimee E. van Dijk, Fawziya O. Alyafei, Tawa Olukade, Neda Razaz, Jonas K. Soderling, Lucy S. Smith, Elizabeth Draper, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella O. Pravia, Eric E. Ohuma, Joy Lawn
Summary: A study compared neonatal mortality rates in 125.5 million live births across 15 countries from 2000 to 2020. The findings showed that preterm newborns with small size for gestational age had the highest mortality rates. At the population level, preterm newborns with appropriate size for gestational age contributed the most to neonatal deaths.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
L. A. Magee, P. von Dadelszen
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Peter N. von Dadelszen, Jeffrey Bone, Akshdeep Sandhu, J. Mark N. Ansermino, Rahat Qureshi, Charfudin Sacoor, Esperanca Sevene, Jing Li, Marianne B. Vidler, Mrutyunjaya A. Bellad, Zulfiqar T. Bhutta, Dustin S. Dunsmuir, Shivaprasad A. Goudar, Ashalata Mallapur, Khatia A. Munguambe, Guy A. Dumont, Laura Magee
Summary: To inform digital health design by evaluating diagnostic test properties of antenatal blood pressure (BP) outputs and levels to identify women at risk of adverse outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
K. S. Joseph, Carmen B. Young, Giulia M. Muraca, Amelie Boutin, Neda Razaz, Sid John, Sarka Lisonkova, R. Douglas Wilson
Summary: There is no clear association between the tier and volume of hospitals and adverse maternal and neonatal outcomes among patients with a previous cesarean delivery in Canada. Therefore, all hospitals should continually assess their rates of adverse outcomes for pregnant women and newborns.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2023)
Article
Peripheral Vascular Disease
Laura A. Magee, David Wright, Argyro Syngelaki, Peter von Dadelszen, Ranjit Akolekar, Alan Wright, Kypros H. Nicolaides
Summary: This study aimed to identify the optimal screening and timing of birth strategy for preventing term preeclampsia. The results showed that screening and delivering at 35-36 weeks had the highest efficacy in preventing term preeclampsia.
Article
Public, Environmental & Occupational Health
Sid John, K. S. Joseph, John Fahey, Shiliang Liu, Michael S. Kramer
Summary: The assessment of birthweight for gestational age and the identification of small-and large-for-gestational age infants remain contentious. Reference and standard-based birthweight-for-gestational age indices and centiles perform poorly in predicting adverse neonatal outcomes in individual infants, and have limited population impact.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jeffrey N. Bone, K. S. Joseph, Sid John, Sarka Lisonkova
Summary: This study compared Cox regression with piecewise exponential additive mixed models (PAMMs) for modeling the relationship between BMI and gestational age-specific rates of stillbirth. PAMMs were found to provide more accurate modeling of time-varying effects.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Letter
Public, Environmental & Occupational Health
Sarka Lisonkova, Jeffrey N. N. Bone, Giulia M. M. Muraca, Neda Razaz, Amelie Boutin, Justin S. S. Brandt, Mohamed A. A. Bedaiwy, Cande V. V. Ananth, K. S. Joseph
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura A. Magee, Erika Molteni, Vicky Bowyer, Jeffrey N. Bone, Harriet Boulding, Asma Khalil, Hiten D. Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma L. Duncan, Peter von Dadelszen
Summary: Among women of reproductive age, older age, White ethnicity, and being in the least-deprived index of multiple deprivation are independently associated with higher vaccine uptake. Ethnicity has the strongest influence, while multiple deprivation has the weakest. These findings are crucial for informing future vaccination policies and public messaging.
NATURE COMMUNICATIONS
(2023)