Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum

Published 2015 View Full Article

Title

Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum

Authors

Keywords

Methotrexate, 7-Hydroxy methotrexate, DAMPA, Carboxypeptidase-G2, Therapeutic drug monitoring, Mass spectrometry, Turbulent flow liquid chromatography, Method correlation, Dihydrofolate reductase inhibition assay, Fluorescence polarization immunoassay

Journal

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Volume 1002, Issue -, Pages 169-175

Publisher

Elsevier BV

Online

2015-08-23

DOI

10.1016/j.jchromb.2015.08.025

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