Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells

Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies

(2010) Laetitia Malphettes et al.   BIOTECHNOLOGY AND BIOENGINEERING

Selection of CHO host cell subclones with increased specific antibody production rates by repeated cycles of transient transfection and cell sorting

(2010) Johannes Pichler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

(2010) Marcella Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Predicting cell-specific productivity from CHO gene expression

(2010) Colin Clarke et al.   JOURNAL OF BIOTECHNOLOGY

25 years of recombinant proteins from reactor-grown cells — Where do we go from here?

(2009) David L. Hacker et al.   BIOTECHNOLOGY ADVANCES

CHO gene expression profiling in biopharmaceutical process analysis and design

(2009) Jochen Schaub et al.   BIOTECHNOLOGY AND BIOENGINEERING

Guidelines to cell engineering for monoclonal antibody production

(2009) A. Rita Costa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?

(2008) Janet Chusainow et al.   BIOTECHNOLOGY AND BIOENGINEERING

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

(2008) Xiangdong Meng et al.   NATURE BIOTECHNOLOGY

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

(2008) Y. Santiago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design

(2007) Wojciech W. Krajewski et al.   JOURNAL OF MOLECULAR BIOLOGY