Article
Engineering, Biomedical
Sanghun Lee, Sehyeon Park, Junggeon Park, Jae Young Lee
Summary: We developed implantable bioelectrodes with high performance and high biocompatibility by actively modulating the inflammatory response of macrophages. The immobilization of anti-inflammatory cytokine IL-4 on the electrodes successfully induced anti-inflammatory polarization of macrophages, both in vitro and in vivo. These IL-4-immobilized bioelectrodes not only mitigated scarring around the implanted electrodes but also maintained high sensitivity electrocardiogram signals for up to 15 days post-implantation.
ACTA BIOMATERIALIA
(2023)
Article
Multidisciplinary Sciences
Robert A. Saxton, Naotaka Tsutsumi, Leon L. Su, Gita C. Abhiraman, Kritika Mohan, Lukas T. Henneberg, Nanda G. Aduri, Cornelius Gati, K. Christopher Garcia
Summary: By determining the structure of the IL-10 receptor complex and uncovering differences in IL-10 response thresholds across immune cell populations, this study provides a mechanistic blueprint for manipulating the pleiotropic actions of IL-10. Some IL-10 variants displayed myeloid-biased activity, suppressing macrophage activation without stimulating inflammatory CD8(+) T cells, thus uncoupling the major opposing functions of IL-10.
Article
Chemistry, Physical
Abdessamad Y. A. Kaassis, Wafa T. Al-Jamal, Margarita Strimaite, Maja Severic, Gareth R. Williams
Summary: Two novel biocompatible hydroxy double salts (HDS), MgZn-Cl and FeZn-Cl, were found to successfully intercalate diclofenac, ibuprofen, and valproate. Drug release studies showed that the solubility of the drug ions controls the fate of the HDS in an acidic environment, with valproate intercalates dissolving completely at pH 1.0 within two hours. The HDS were also found to be biocompatible and stable upon storage for 5 years in vitro.
APPLIED CLAY SCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Jing Wei, Jinyu Mu, Yong Tang, Dalian Qin, Junguo Duan, Anguo Wu
Summary: This review investigates the potential of advanced nanomaterials in revolutionizing ocular anti-inflammatory drug interventions. It explores different categories of nanomaterials and their unique properties for drug delivery, while also discussing the challenges and advantages of these systems. The review emphasizes the importance of interdisciplinary collaborations in advancing this field.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Polymer Science
Jon Andrade del Olmo, Leyre Perez-Alvarez, Virginia Saez Martinez, Sandra Benito Cid, Raul Perez Gonzalez, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: This study describes the use of crosslinked hyaluronic acid hydrogels loaded with antibiotics and an anti-inflammatory agent for promoting antibacterial and anti-inflammatory responses. The hydrogels were thoroughly characterized and demonstrated biological safety and efficacy in vitro.
Article
Endocrinology & Metabolism
Maria Krajewska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Anna Stelmaszczyk-Emmel, Maria Sobol, Anna Majcher, Beata Pyrzak
Summary: The study found that vitamin D supplementation had beneficial effects in overweight and obese children, reducing inflammation levels and stabilizing anti-inflammatory cytokines.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Neurosciences
Hashim Islam, Helena Neudorf, Alice L. Mui, Jonathan P. Little
Summary: Interpreting changes in circulating cytokine concentrations as evidence for altered inflammation may overlook important functional changes in cytokine action at the tissue/cellular level, due to factors influencing cytokine function. Therefore, relying solely on changes in cytokine concentrations may miss significant alterations in inflammatory processes.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Jon Andrade del Olmo, Leyre Perez Alvarez, Virginia Saez-Martinez, Sandra Benito-Cid, Leire Ruiz-Rubio, Raul Perez-Gonzalez, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: Chitosan-based hydrogels have the potential to promote wound healing and relieve inflammation and chronic infections. By crosslinking Chitosan with genipin, biocompatible hydrogels with antibacterial activity were obtained. These hydrogels effectively treated ulcerated wounds and demonstrated synergistic anti-inflammatory effects when combined with non-steroidal anti-inflammatory drugs and antibiotics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Omprakash Sunnapu, Rajamohammed Khader, Mukesh Dhanka, Praveen Kumar Vemula, Sekar Karuppannan
Summary: Delivery of drugs in response to inflammation and inflammation-associated enzymes may have a beneficial effect in managing inflammatory diseases. In this study, a hydrogel system responsive to inflammation-associated enzymes was developed, with encapsulated zingerone exhibiting anti-inflammatory properties. The system demonstrated responsive release of zingerone in vitro, and its in vivo efficacy will be evaluated in future preclinical models.
Article
Chemistry, Multidisciplinary
Binglin Sui, Mingming Wang, Chen Cheng, Quanguang Zhang, Jiajia Zhang, Daping Fan, Peisheng Xu
Summary: The Nano-ERASER technique, utilizing an antibody-conjugated polymer nanogel system, facilitates targeted intracellular delivery, release, and degradation of specific endogenous proteins, showing promising efficacy and convenience in studying protein function and potentially serving as a novel therapeutic modality for cancer and other diseases.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Engineering, Biomedical
Long Chen, Yuanzheng Wang, Li Sun, Jerry Yan, Hai-Quan Mao
Summary: Noninfectious arthritis encompasses chronic and progressive inflammatory disorders that require early management. Common forms include osteoarthritis, rheumatoid arthritis, and nanomedicine shows promise in improving therapeutic efficacy while reducing side effects and extending drug half-life.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Immunology
Joshua H. Cho, Saumya Bhutani, Carole H. Kim, Michael R. Irwin
Summary: This review examined the potential of exogenous melatonin in reducing inflammatory markers in humans. Results showed significant anti-inflammatory effects of melatonin on certain markers, suggesting its potential as a preventative and adjunct treatment for inflammatory disorders in older populations.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Liliana A. Gonzalez, Felipe Melo-Gonzalez, Valentina P. Sebastian, Omar P. Vallejos, Loreani P. Noguera, Isidora D. Suazo, Barbara M. Schultz, Andres H. Manosalva, Hernan F. Penaloza, Jorge A. Soto, Dane Parker, Claudia A. Riedel, Pablo A. Gonzalez, Alexis M. Kalergis, Susan M. Bueno
Summary: The study revealed that neutrophils are the main source of IL-10 production in the lungs during early infection with Streptococcus pneumoniae, and IL-10 can be induced in these cells by directly recognizing pneumococcal antigens. Adoptive transfer of neutrophils from WT mice into IL-10 knockout mice restored IL-10 production and reduced lung histopathology, indicating the importance of IL-10 in limiting lung injury and mediating an effective immune response for host survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zifei Han, Shelli R. McAlpine, Robert Chapman
Summary: This study demonstrates the successful delivery of inhibitors to block the interaction between Hsp70 and HOP using polymer nanogels. The results show the effectiveness of these inhibitors in inhibiting Hsp70 and inducing cancer cell death.
BIOORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Ilya Eydelman, Na'ama Zehavi, Valeria Feinshtein, Dinesh Kumar, Shimon Ben-Shabat, Amnon C. Sintov
Summary: A new particulate system for delivering CBD into the brain via intranasal route is presented. CBD-loaded starch nanoparticles showed higher levels of cannabidiol in the brain compared to an identical cannabidiol solution. The starch nanoparticles demonstrated low toxicity and anti-inflammatory activity, making them a suitable platform for efficacious cannabidiol delivery and activity in the central nervous system.
Article
Plant Sciences
Ana S. Oliveira, Joana Rolo, Carlos Gaspar, Leonor Ramos, Carlos Cavaleiro, Ligia Salgueiro, Rita Palmeira-de-Oliveira, Joao Paulo Teixeira, Jose Martinez-de-Oliveira, Ana Palmeira-de-Oliveira
Summary: This study evaluated the bioactivities of Thymus mastichina and Cistus ladanifer essential oils and hydrolates in skin ailments, including antioxidant, anti-inflammatory, cytotoxic, wound healing, and antimicrobial properties. The results showed that Cistus ladanifer essential oil exhibited higher anti-inflammatory and antimicrobial potential, but also had some cytotoxicity. Thymus mastichina preparations had anti-inflammatory potential and better biocompatibility. Both species' hydrolates showed good potential in promoting cell migration and wound healing.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Robertina Giacconi, Blanca Laffon, Solange Costa, Armanda Teixeira-Gomes, Fabrizio Maggi, Lisa Macera, Pietro Giorgio Spezia, Francesco Piacenza, Alexander Buerkle, Maria Moreno-Villanueva, Stefano Bonassi, Vanessa Valdiglesias, Joao Paulo Teixeira, Martijn E. T. Dolle, M. Liset Rietman, Eugene Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Birgit Weinberger, Ewa Sikora, Wolfgang Stuetz, Olivier Toussaint, Florence Debacq-Chainiaux, Antti Hervonen, Mikko Hurme, P. Eline Slagboom, Christiane Schoen, Juergen Bernhardt, Nicolle Breusing, Eduardo Pasaro, Ana Maseda, Laura Lorenzo-Lopez, Jose C. Millan-Calenti, Mauro Provinciali, Marco Malavolta
Summary: This study analyzed the association between TTV viremia and physical frailty and cognitive impairment. The results showed that TTV viremia was associated with physical frailty and cognitive impairment. However, the association varied in different study samples.
Review
Environmental Sciences
Maria Joao Bessa, Fatima Brandao, Fernanda Rosario, Luciana Moreira, Ana Teresa Reis, Vanessa Valdiglesias, Blanca Laffon, Sonia Fraga, Joao Paulo Teixeira
Summary: Several studies have investigated the potential adverse health risks associated with exposure to nanoscale materials. In vitro model systems provide important information about the molecular mechanisms of action, while in vivo studies are crucial for understanding the relationship between dose and adverse effects. This review focuses on the toxicity assessment of inhaled (nano)particulate materials and provides an overview of available human respiratory models and exposure systems for in vitro testing, as well as their advantages, limitations, and current research.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2023)
Review
Gastroenterology & Hepatology
Sara Oliveira de Brito, Diogo Libanio, Claudia Martins Marques Pinto, Joao Pedro Pinho Osorio de Araujo Teixeira, Joao Paulo Meireles de Araujo Teixeira
Summary: LECS, as a novel combined surgical approach, combines the advantages of endoscopy and laparoscopy for the effective treatment of upper gastrointestinal lesions. The study found that LECS showed comparable efficacy and safety to existing techniques, with a trend towards shorter hospitalization time, longer procedure duration, and fewer adverse events. However, it is important to note that the existing studies are mainly retrospective cohorts and more prospective studies are needed to evaluate the superiority of LECS.
GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Chemistry, Applied
Sonia S. Ferreira, Alexandra Correia, Artur M. S. Silva, Dulcineia Ferreira Wessel, Susana M. Cardoso, Manuel Vilanova, Manuel A. Coimbra
Summary: Broccoli by-products were used to study the structure-function relationships and immunostimulatory activity of pectic polysaccharides. Pectic polysaccharides extracted by hot water showed high immunostimulatory activity, which was further enhanced by treatment with 80% ethanol. The action of pectin methylesterase and endo-polygalacturonase on the polysaccharides resulted in a fraction with high immunostimulatory activity. Therefore, agri-food by-products are an important source of pectic polysaccharide functional food ingredients.
CARBOHYDRATE POLYMERS
(2023)
Article
Genetics & Heredity
Peter Moller, Amaya Azqueta, Julen Sanz-Serrano, Tamara Bakuradze, Elke Richling, Ezgi Eyluel Bankoglu, Helga Stopper, Victoria Claudino Bastos, Sabine A. S. Langie, Annie Jensen, Francesca Scavone, Lisa Giovannelli, Maria Wojewodzka, Marcin Kruszewski, Vanessa Valdiglesias, Blanca Laffon, Carla Costa, Solange Costa, Joao Paulo Teixeira, Mirko Marino, Cristian Del Bo, Patrizia Riso, Congying Zheng, Sergey Shaposhnikov, Andrew Collins
Summary: Measurement of DNA migration in the comet assay can be done through image analysis or visual scoring, with the latter accounting for a significant portion of the published results. This study examines the variability in visual scoring of comets among different investigators and suggests the use of three reference sets for scoring. The results show both inter-investigator and intra-investigator variation in scoring, indicating a need for further standardization, but also demonstrate that visual scoring remains a reliable method for analyzing DNA migration in comets.
Article
Genetics & Heredity
Peter Moller, Amaya Azqueta, Miguel Collia, Tamara Bakuradze, Elke Richling, Ezgi Eyluel Bankoglu, Helga Stopper, Victoria Claudino Bastos, Sabine A. S. Langie, Annie Jensen, Sara Ristori, Francesca Scavone, Lisa Giovannelli, Maria Wojewodzka, Marcin Kruszewski, Vanessa Valdiglesias, Blanca Laffon, Carla Costa, Solange Costa, Joao Paulo Teixeira, Mirko Marino, Cristian Del Bo, Patrizia Riso, Congying Zheng, Sergey Shaposhnikov, Andrew Collins
Summary: The comet assay is a versatile method for measuring DNA damage, but there is no agreement on optimal assay conditions or suitable assay controls, resulting in inter-laboratory variation. The hCOMET ring trial tested KBrO3 as a positive control for the Fpg-modified comet assay and demonstrated its robustness. However, inter-laboratory variation in DNA migration levels remains a concern.
Article
Materials Science, Multidisciplinary
Gloria Young, Francesca Tallia, Jeffrey N. Clark, Manishankar Chellappan, Oriol Gavalda-Diaz, Enric Juan Alcocer, Silvia A. Ferreira, Sara M. Rankin, Joshua P. Clark, John Hanna, Jonathan R. T. Jeffers, Julian R. Jones
Summary: Researchers have developed tough materials with continuous composition and stiffness gradients using inorganic/organic hybrid materials that can be 3D printed. Through the use of sol-gel hybrid materials with interacting organic and inorganic co-networks, the mechanical behavior can be tuned. These materials have a wide range of mechanical properties, from elastomeric to glassy, and can be used in additive manufacturing of 3D structures. The development of seamless stiffness gradients has potential applications in biomimicry and tissue engineering.
MATERIALS TODAY ADVANCES
(2023)
News Item
Immunology
Iris Caramalho, Maria Strecht Almeida, Manuel Vilanova, Carlos Penha-Goncalves
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Ana Teresa Reis, Carla Costa, Sonia Fraga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Peter Moller, Amaya Azqueta, Adriana Rodriguez-Garraus, Tamara Bakuradze, Elke Richling, Ezgi Eyluel Bankoglu, Helga Stopper, Victoria Claudino Bastos, Sabine A. S. Langie, Annie Jensen, Sara Ristori, Francesca Scavone, Lisa Giovannelli, Maria Wojewodzka, Marcin Kruszewski, Vanessa Valdiglesias, Blanca Laffon, Carla Costa, Solange Costa, Joao Paulo Teixeira, Mirko Marino, Cristian Del Bo, Patrizia Riso, Congying Zheng, Sergey Shaposhnikov, Andrew Collins
Summary: Accumulation of DNA strand breaks during cryopreservation is not a concern for mononuclear blood cell lines, and there is inter-laboratory variation in the results.
Article
Genetics & Heredity
Peter Moller, Amaya Azqueta, Adriana Rodriguez-Garraus, Tamara Bakuradze, Elke Richling, Ezgi Eyluel Bankoglu, Helga Stopper, Victoria Claudino Bastos, Sabine A. S. Langie, Annie Jensen, Sara Ristori, Francesca Scavone, Lisa Giovannelli, Maria Wojewodzka, Marcin Kruszewski, Vanessa Valdiglesias, Blanca Laffon, Carla Costa, Solange Costa, Joao Paulo Teixeira, Mirko Marino, Cristian Del Bo', Patrizia Riso, Congying Zheng, Sergey Shaposhnikov, Andrew Collins
Summary: The study finds that potassium bromate is a suitable positive control for the Fpg-modified comet assay, which is widely used to measure oxidatively generated damage to DNA. Although all laboratories obtained positive concentration-response relationships, there was variation in the levels of Fpg-sensitive sites between different laboratories. However, the consistency between the measurements of %Tail DNA values and visual scores of comet images done in the central laboratory suggests a potential source of inter-laboratory variation.
Article
Nanoscience & Nanotechnology
Fatima Brandao, Carla Costa, Maria Joao Bessa, Vanessa Valdiglesias, Bryan Hellack, Andrea Haase, Sonia Fraga, Joao Paulo Teixeira
Summary: This study assessed the cytotoxicity and genotoxicity of different-sized and surface-modified amorphous silica nanomaterials on rat alveolar epithelial cells. The results showed that variants with larger surface areas had higher cytotoxic potential, SiO2_40 induced significant DNA damage, and all tested variants increased gamma-H2AX levels. This study supports the use of multiparametric approaches to improve understanding of nanomaterial mechanisms and hazard prediction.
Article
Toxicology
Maryam Zare Jeddi, Karen S. Galea, Susana Viegas, Peter Fantke, Henriqueta Louro, Jan Theunis, Eva Govarts, Sebastien Denys, Clemence Fillol, Loic Rambaud, Marike Kolossa-Gehring, Tiina Santonen, Hilko van der Voet, Manosij Ghosh, Carla Costa, Joao Paulo Teixeira, Hans Verhagen, Radu-Corneliu Duca, An Van Nieuwenhuyse, Kate Jones, Craig Sams, Ovnair Sepai, Giovanna Tranfo, Martine Bakker, Nicole Palmen, Jacob van Klaveren, Paul T. J. Scheepers, Alicia Paini, Cristina Canova, Natalie von Goetz, Andromachi Katsonouri, Spyros Karakitsios, Dimosthenis A. Sarigiannis, Jos Bessems, Kyriaki Machera, Stuart Harrad, Nancy B. Hopf
Summary: The impact of the environment on health is a necessary result of human activity. Environmental health sciences aim to understand how people are exposed to hazardous chemicals that can harm their health. Implementing the FAIR principles for scientific data management can greatly enhance the efficiency and effectiveness of exposure sciences and environmental epidemiology.
FRONTIERS IN TOXICOLOGY
(2023)