Article
Chemistry, Multidisciplinary
Halina Szatylowicz, Olga A. Stasyuk, Miquel Sola, Tadeusz M. Krygowski
Summary: The 3D shape and physicochemical properties of double-helical DNA/RNA structures are determined by intermolecular interactions of nucleobases. Aromatic pi-pi stacking plays a significant role in stabilizing DNA/RNA. The pi-electron structure of nucleobases and noncovalent interactions affect their stability.
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Xi Khai Wong, Keng Yoon Yeong
Summary: Nucleobases and their analogues play vital roles in drug development, particularly in the treatment of cancer, viral, and bacterial infections. Molecular modifications on nucleobases and their isolation from natural sources provide new avenues for the development of more potent drugs.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Rinky Sha, Nandimalla Vishnu, Sushmee Badhulika
Summary: This work demonstrates the synthesis of marcasite FeS2 as a low-cost electrochemical platform for the separation-less sensing of four nucleobases of DNA. The marcasite FeS2 exhibits high surface area micro-flowers with vertically grown interwoven 2D nanosheets. Under optimized conditions, the marcasite FeS2 electrode can simultaneously determine multiple DNA bases with excellent reproducibility and stability. Moreover, the sensor is successfully utilized for the detection of nucleobases of denatured DNA, showing potential for bio-analytical and sensing applications.
IEEE TRANSACTIONS ON NANOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Thomas M. Asrat, Whirang Cho, Favian A. Liu, Sarah M. Shapiro, John R. Bracht, Alexander G. Zestos
Summary: The study demonstrates the subsecond codetection of nucleobases in DNA and RNA samples from the nematode using fast-scan cyclic voltammetry. FSCV shows higher sensitivity and peak oxidative currents when detecting shorter oligonucleotides and single-stranded DNA samples. Single-stranded DNA nucleobases are not hydrogen-bonded and can freely adsorb onto the electrode surface, enabling successful simultaneous determination of nucleobases even in complex biological samples.
Article
Chemistry, Organic
K. P. Nandhini, Sikabwe Noki, Edikarlos Brasil, Fernando Albericio, Beatriz G. de la Torre
Summary: Peptide Nucleic Acids (PNAs) are a class of synthetic biomolecules with great potential in medicine. A new PNA SPS strategy based on a safety-catch protecting group scheme has been developed, allowing the synthesis of PNAs using Boc as a temporal protecting group.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Physical
Maria Yermolina, Assma Ali, Alexa Cabrera, George A. Papadantonakis
Summary: Density Functional Theory (DFT) calculations reveal the mechanism of methylation reaction on adenine and the relationship between activation barrier and the number of water molecules.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2022)
Article
Acoustics
Reshma Kaimal, Patel Nishant Mansukhlal, Belqasem Aljafari, Sambandam Anandan, Muthupandian Ashokkumar
Summary: The gold-loaded boron-doped graphene quantum dots interface was prepared via ultrasound-aided reduction method for electrochemical monitoring of guanine-GUA and adenine-ADE in DNA. The resulting sensor showed wide linear range, low detection limit, excellent sensitivity and selectivity, as well as prominent selectivity, reproducibility, and stability.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Brennan Mao, Lanting Qian, Maduraiveeran Govindhan, Zhonggang Liu, Aicheng Chen
Summary: A rapid and sensitive electrochemical sensing platform based on bimetallic gold-platinum nanoclusters dispersed on reduced graphene oxide was developed for the simultaneous detection of guanine and adenine. The sensor exhibited outstanding electrocatalytic performance, low detection limits, high sensitivity, and a wide linear range for both analytes, as well as negligible interference from common interferents. The proposed platform successfully enabled the simultaneous sensing of guanine and adenine in denatured Salmon Sperm DNA, showcasing its potential for clinical diagnosis and biomedical applications.
Article
Chemistry, Analytical
Jing Chen, Shuying Li, Ying Chen, Jiao Yang, Jianbin Dong
Summary: NH2-MIL-53(Fe)/CS/MXene nanocomposites were prepared for detecting guanine and adenine in DNA and RNA. The electrochemical catalytic oxidation of adenine and guanine was successfully performed using differential pulse voltammetry. The nanocomposite exhibited high sensitivity for detecting low concentrations of adenine and guanine.
Article
Chemistry, Analytical
Shujie Lv, Ruiju Shi, Ruhong Yan, Peng Miao
Summary: An electrochemical method using a self-assembled poly-adenine (polyA) based primer is developed to measure telomerase activity. Abundant DNA-templated copper nano-particles (CuNPs) are captured by target telomerase, acting as electrochemical signal sources. The method exhibits a wide dynamic range and low detection limit, providing an effective approach for monitoring telomerase activity in cancer diagnostics.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
H. Hemanth, Sairam S. Mallajosyula
Summary: This study used polarizable molecular dynamics simulation to investigate the self-assembly of nucleobases on a graphene sheet. The introduction of polarization led to significant changes in interaction patterns, including the stacking probability in guanine-rich systems and the formation of hydrogen-bonded structures on the graphene sheet, highlighting the importance of DNA sequence and composition.
Article
Chemistry, Analytical
Shantharaja, Manjunatha Nemakal, Giddaerappa, Subramanya Gopal Hegde, Lokesh Koodlur Sannegowda
Summary: Biomolecules like adenine and guanine play important roles in DNA and RNA molecules, and their alteration and deficiency can lead to health issues. This paper presents a method using a Cu(II)TPTAPc film-modified electrode for simultaneous determination and monitoring of adenine and guanine. The electrode showed good sensitivity and selectivity.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Maria Chiara Storer, Christopher A. Hunter
Summary: The H-bonding properties of compounds with multiple functional groups are hard to predict due to through-bond polarisation effects and long-range secondary electrostatic interactions. This study quantifies the magnitude of these effects using experimental measurements and develops a computational method for accurate calculation of functional group H-bond parameters. The results provide insights into the interaction properties of molecules with multiple functional groups.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Analytical
Xin Zhao, Hao Guo, Rui Xue, Mingyue Wang, Qixia Guan, Tian Fan, Wenhu Yang, Wu Yang
Summary: In this study, a dual-signal amplification biosensor for simultaneous detection of adenine and guanine was fabricated by using COFs, NH2-rG, and MoS2 to modify a glassy carbon electrode. The biosensor exhibited excellent performance with wide linear ranges and low detection limits for G and A, showing simplicity, speed, high sensitivity, good reproducibility, and long-term stability.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Lei Zhang, Hanieh Farkhondeh, Fatemeh Rahnemaye Rahsepar, Avisek Chatterjee, Kam Tong Leung
Summary: This study investigates the adsorption and film growth of DNA base molecules (cytosine, guanine, thymine, and adenine) on Si(111)7x7 using XPS and DFT calculations. The results reveal multiple tautomeric forms and keto-enol tautomerization, as well as the role of the reactive surface in triggering tautomerization.
Article
Spectroscopy
Omid Heydari Shayesteh, Raouf Ghavami
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2020)
Article
Chemistry, Multidisciplinary
Delnia Bahari, Bahareh Babamiri, Abdollah Salimi
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Analytical
Zolaikha Rasouli, Raouf Ghavami
Article
Chemistry, Multidisciplinary
Negar Alizadeh, Abdollah Salimi, Tsun-Kong Sham, Paul Bazylewski, Giovanni Fanchini
Article
Chemistry, Analytical
Delnia Bahari, Bahareh Babamiri, Abdollah Salimi, Rahman Hallaj, S. Mojtaba Amininasab
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Multidisciplinary
Zolaikha Rasouli, Raouf Ghavami
Article
Materials Science, Ceramics
A. Vojdani Saghir, S. Mollazadeh Beidokhti, J. Vahdati Khaki, A. Salimi
Summary: Thermodynamic calculations were used to determine the conditions for single-phase (Co, Mg, Ni, Cu, Zn) O particle synthesis, while the impact of activities coefficients alteration on the formation of these particles was also evaluated. Experimental results showed that glycine synthesis under fuel-lean conditions produced promising (Co, Mg, Ni, Cu, Zn) O powders with specific physicochemical properties.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Chemistry, Analytical
Delnia Bahari, Bahareh Babamiri, Abdollah Salimi, Himen Salimizand
Summary: A ratiometric fluorescent apta-sensor was developed for sensitive and selective detection of Acinetobacter baumannii (Ab) bacteria in biological samples, based on fluorescence resonance energy transfer (FRET) between ortho-phenylenediamines carbon dot (o-CD), nitrogen-doped carbon nanodots (NCND) as donor's species, and graphene oxide (GO) as acceptor. The sensor showed a wide range of fluorescence intensity ratio variation with the change in bacterial concentration and a low detection limit, demonstrating its feasibility for selective detection of A. baumannii in urine samples.
Review
Biotechnology & Applied Microbiology
Negar Alizadeh, Abdollah Salimi
Summary: Nanozymes, nanomaterials with enzyme-like catalytic activity, have drawn significant attention for their low cost, high stability, and ease of recycling, making them a convenient substitute for natural enzymes in various applications. This review summarizes the latest progress in the applications of metal and metal oxide nanozymes in sensing, cancer therapy, water treatment, and anti-bacterial efficacy, highlighting their potential in disease prevention and diagnostic monitoring for future pandemics.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Tina Naghdi, Shadab Faham, Tohid Mahmoudi, Nahid Pourreza, Raouf Ghavami, Hamed Golmohammadi
Article
Chemistry, Physical
Aso Navaee, Abdollah Salimi, Tsun-Kong Sham
Summary: A rapid and simple method for synthesis of graphdiyne-like nanosheets with remarkable photocatalytic activity is proposed in this study.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Chemistry, Analytical
Susan Mohammadi, Somayeh Mohammadi, Abdollah Salimi
Summary: The study successfully fabricated carbon dots-chitosan nanocomposite hydrogels for the detection of microRNA-21 in MCF-7 cancer cells, demonstrating high stability and sensitivity. The biosensors exhibited good linearity with MCF-7 cancer cell concentrations and low detection limits, indicating potential applications in the field.
Article
Chemistry, Analytical
Zolaikha Rasouli, Raouf Ghavami
Summary: A simple and efficient sensor array based on nanoaggregation of curcumin was developed for the identification and quantification of metal ions. The nanocurcumin was characterized by UV-Vis, TEM, and FT-IR for distinguishing metal ions through UV-Vis absorbance changes.
Article
Chemistry, Multidisciplinary
Fereydoun Sadeghi, Abbas Afkhami, Tayyebe Madrakian, Raouf Ghavami
Summary: A study on anthracycline derivatives was conducted to establish a quantitative structure-activity relationship model. The model, developed using a genetic algorithm and multiple linear regression, demonstrated high stability and robustness in predicting inhibitory concentrations of analogs. The model was successfully generalized to other compounds, aiding in the selection of potent drug candidates.
Article
Chemistry, Analytical
Bahareh Feyzi-barnaji, Behzad Darbasizadeh, Elham Arkan, Hamid Salehzadeh, Abdollah Salimi, Fatemeh Nili, Rassoul Dinarvand, Ali Mohammadi
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2020)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
