Article
Biochemistry & Molecular Biology
Emmanuelle Berger, Alain Geloen
Summary: Adipose tissue hypertrophy during obesity has various effects on health, and the expandability of adipose tissue depends on the size and number of adipocytes. The accumulation of lipids as triglycerides in mature adipocytes is regulated by lipid uptake and lipolysis. This study aims to understand the mechanisms involved in fat mass regulation through fatty acid/FAT-CD36 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Jing Duan, Jingkai Pan, Meichen Sun, Yulin Fang
Summary: Ellagic acid (EA), a polyphenol found in fruits and vegetables, can be used as a functional ingredient. This study found that supplementing with EA significantly reduced the body weight of young mice but not adult mice. EA also affected the abundance of certain gut bacteria differently in young and adult mice.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Neurosciences
Ana-Maria Dobri, Maria Dudau, Ana-Maria Enciu, Mihail Eugen Hinescu
Summary: CD36 is a membrane protein widely distributed in the human body, enriched in the monocyte-macrophage system and endothelial cells, involved in the cellular uptake of long chain fatty acids and oxidized low-density lipoproteins, as well as binding hydrophobic amyloid fibrils found in Alzheimer's disease brain. Therapeutic approaches mainly focus on CD36 blockade and upregulation, but the balance centered on microglia remains poorly understood at this stage.
Article
Biochemistry & Molecular Biology
Fang Li, Zhuoran Kang, Xiaojuan Wu, Wei Wu
Summary: Dietary protein plays a crucial role in body growth and shaping the gut microbiota. This study found that oxidation of rice bran protein (RBP) altered the composition of the gut microbiota, improved intestinal barrier function, but had limited effects on short-chain fatty acid production.
Article
Food Science & Technology
Lars Stoermer, Martin Globisch, Thomas Henle
Summary: The formation of selected glycerol-bound oxidized fatty acids (GOFAs), including 9-oxononanoic acid (9-ONA), azelaic acid (AZA) and octanoic acid, was observed in peanuts roasted at 170 degrees C. The content of octanoic acid and AZA increased with roasting time, while the content of 9-ONA initially decreased and then increased again. 9-ONA and octanoic acid are potential markers of thermal processes.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Ling-Jun Li, Ruochen Du, Marion Ouidir, Ruijin Lu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul S. Albert, Cuilin Zhang
Summary: Saturated fatty acids (SFAs) during pregnancy have an impact on metabolic programming and fetal growth. In this study, plasma phospholipid SFAs were measured in early pregnancy and fetal growth was monitored. It was found that even-chain and very long even-chain SFAs were negatively associated, while odd-chain SFAs were positively associated with fetal weight and size. Pentadecanoic acid (15:0) in the highest tertile showed a greater fetal weight and size compared to the lowest tertile. These findings suggest the potential use of an alternative high-fat diet rich in odd-chain SFAs for optimal fetal growth.
Article
Multidisciplinary Sciences
Kristin J. Skaarud, Johannes R. Hov, Simen H. Hansen, Martin Kummen, Jorgen Valeur, Ingebjorg Seljeflot, Asta Bye, Vemund Paulsen, Knut E. A. Lundin, Marius Troseid, Geir E. Tjonnfjord, Per Ole Iversen
Summary: After allo-HSCT, gut microbiota and short-chain fatty acids were significantly reduced, with no significant differences between the intervention group and controls in investigated parameters. Patients with low microbial diversity at 3 weeks post-HSCT had significantly higher mortality rates, while those with higher abundance of Blautia genus were more likely to survive.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Lisa F. M. Lee Nen That, Baojun Xu, Jessica Pandohee
Summary: The maturation of omics technologies and bioinformatics tools has greatly advanced prebiotics research. Prebiotics are no longer limited to oligosaccharides, but include various compounds that have been proven to have prebiotic characteristics. The discovery of novel prebiotics requires further understanding of their roles in the microbiota and the host. The relationship between the gut microbiota and the host is crucial for health, and dysbiosis can result in severe illnesses.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Multidisciplinary Sciences
Andrew C. Tolonen, Nicholas Beauchemin, Charlie Bayne, Lingyao Li, Jie Tan, Jackson Lee, Brian Meehan, Jeffrey Meisner, Yves Millet, Gabrielle LeBlanc, Robert Kottler, Erdmann Rapp, Chris Murphy, Peter J. Turnbaugh, Geoffrey von Maltzahn, Christopher M. Liu, Johan E. T. van Hylckama Vlieg
Summary: The authors characterized the properties of chemically diverse synthetic glycans (SGs) in modulating the gut microbiome and demonstrated their therapeutic potential in mouse models of colonic inflammation. The study suggests that SGs could be a promising avenue for treating diseases by altering the composition and metabolites produced by the gut microbiome.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Azemina Bajramova, Peter Spegel
Summary: This study compares the nutritional value of the fatty acid profiles of superfruits (goji berry, white mulberry, and cranberry) and common fruits (banana, apple, and strawberry). The findings suggest that cranberries and apples have the most beneficial lipid profiles, while superfruits do not show a common and beneficial lipid profile.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Oncology
Alessia Filippone, Giovanna Casili, Sarah Adriana Scuderi, Deborah Mannino, Marika Lanza, Michela Campolo, Irene Paterniti, Anna Paola Capra, Cristina Colarossi, Annalisa Bonasera, Sofia Paola Lombardo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study investigates the interaction between propionate and PPAR-gamma in glioblastoma and suggests that targeting the PPAR-gamma/SCFAs axis may be a potential therapeutic approach for the management of glioblastoma.
Review
Nutrition & Dietetics
Laury Sellem, Matthieu Flourakis, Kim G. Jackson, Peter J. Joris, James Lumley, Szimonetta Lohner, Ronald P. Mensink, Sabita S. Soedamah-Muthu, Julie A. Lovegrove
Summary: This systematic review assessed the impact of individual saturated fatty acids (SFAs) and their substitutions with other fatty acids on the prevention of cardiometabolic disease (CMD). The results showed that replacing palmitic acid with unsaturated fatty acids can lower LDL-cholesterol concentrations, but no significant effects were observed on other CMD risk markers.
ADVANCES IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Angela Criscuolo, Palina Nepachalovich, Diego Fernando Garcia-del Rio, Mike Lange, Zhixu Ni, Massimo Baroni, Gabriele Cruciani, Laura Goracci, Matthias Blueher, Maria Fedorova
Summary: This study utilizes bioinformatics and LC-MS/MS technologies to uncover the diversity and specificity of modified lipids in human blood plasma of lean and obese individuals, revealing the significant alteration of endocrine signaling by oxidized lipids in metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Ma'mon M. Hatmal, Walhan Alshaer, Ismail S. Mahmoud, Mohammad A. I. Al-Hatamleh, Hamzeh J. Al-Ameer, Omar Abuyaman, Malek Zihlif, Rohimah Mohamud, Mais Darras, Mohammad Al Shhab, Rand Abu-Raideh, Hilweh Ismail, Ali Al-Hamadi, Ali Abdelhay
Summary: In this study involving the Jordanian population, the role of CD36 gene polymorphisms in T2DM and dyslipidemia was investigated, with no significant association found between the two. Various machine learning tools were used for prediction, showing promising results for developing diagnostic and prognostic models for a wide range of diseases based on input data.
Article
Engineering, Environmental
Muhammad Usman, Shuai Zhao, Byong-Hun Jeon, El-Sayed Salama, Xiangkai Li
Summary: This study demonstrated the detailed metabolic pathway of beta-oxidation for saturated and unsaturated fatty acids during anaerobic digestion, and found that C16:0 had no negative impact on the process.
Article
Medicine, Research & Experimental
Shinhye Lee, Ai Eguchi, Kazuhiro Sakamoto, Shigenobu Matsumura, Satoshi Tsuzuki, Kazuo Inoue, Daisaku Masuda, Shizuya Yamashita, Tohru Fushiki
BIOMEDICAL RESEARCH-TOKYO
(2015)
Article
Nutrition & Dietetics
Kazuhiro Sakamoto, Shigenobu Matsumura, Yoko Okafuji, Ai Eguchi, Shinhye Lee, Shin-ichi Adachi, Mina Fujitani, Satosh Tsuzuki, Kazuo Inoue, Tohru Fushiki
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2015)
Article
Psychology, Biological
Kazuhiro Sakamoto, Shigenobu Matsumura, Yoko Okafuji, Ai Eguchi, Takeshi Yoneda, Takafumi Mizushige, Satoshi Tsuzuki, Kazuo Inoue, Tohru Fushiki
PHYSIOLOGY & BEHAVIOR
(2015)
Article
Medicine, Research & Experimental
Miao Zheng, Shinhye Lee, Satoshi Tsuzuki, Kazuo Inoue, Daisaku Masuda, Shizuya Yamashita, Toshihiko Iwanaga
BIOMEDICAL RESEARCH-TOKYO
(2016)
Article
Medicine, Research & Experimental
Satoshi Tsuzuki, Takahiko Amitsuka, Tatsuya Okahashi, Yuki Kozai, Masayuki Yamasaki, Kazuo Inoue, Tohru Fushiki
BIOMEDICAL RESEARCH-TOKYO
(2016)
Article
Biochemistry & Molecular Biology
Satoshi Tsuzuki, Takahiko Amitsuka, Tatsuya Okahashi, Yuki Kozai, Shigenobu Matsumura, Kazuo Inoue, Tohru Fushiki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2016)
Article
Agriculture, Multidisciplinary
Satoshi Tsuzuki, Takahiko Amitsuka, Tatsuya Okahashi, Yusaku Kimoto, Kazuo Inoue
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Satoshi Tsuzuki, Masayuki Yamasaki, Yuki Kozai, Tatsuya Sugawara, Yuki Manabe, Kazuo Inoue, Tohru Fushiki
JOURNAL OF BIOCHEMISTRY
(2017)
Article
Medicine, Research & Experimental
Satoshi Tsuzuki, Yusaku Kimoto, Shinhye Lee, Tatsuya Sugawara, Yuki Manabe, Kazuo Inoue
BIOMEDICAL RESEARCH-TOKYO
(2018)
Article
Biochemistry & Molecular Biology
Kazuhiro Sakamoto, Tatsuya Okahashi, Shigenobu Matsumura, Yoko Okafuji, Shin-ichi Adachi, Satoshi Tsuzuki, Kazuo Inoue, Tohru Fushiki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Shinhye Lee, Ai Eguchi, Satoshi Tsuzuki, Shigenobu Matsumura, Kazuo Inoue, Toshihiko Iwanaga, Daisaku Masuda, Shizuya Yamashita, Tohru Fushiki
Article
Medicine, Research & Experimental
Satoshi Tsuzuki, Shinhye Lee, Yusaku Kimoto, Tatsuya Sugawara, Yuki Manabe, Kazuo Inoue
BIOMEDICAL RESEARCH-TOKYO
(2018)
Article
Agriculture, Multidisciplinary
Satoshi Tsuzuki
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Shinhye Lee, Satoshi Tsuzuki, Takahiko Amitsuka, Daisaku Masuda, Shizuya Yamashita, Kazuo Inoue
BIOMEDICAL RESEARCH-TOKYO
(2017)