Article
Biochemistry & Molecular Biology
Sara Petrillo, Jessica D'Amico, Francesco Nicita, Caterina Torda, Gessica Vasco, Enrico S. Bertini, Marco Cappa, Fiorella Piemonte
Summary: This study reveals the significant role of ferroptosis in the development and progression of X-linked adrenoleukodystrophy (X-ALD) and identifies a different antioxidant response between patients with AMN and cALD.
Article
Biochemistry & Molecular Biology
Schuyler D. Vickers, Stephanie A. Shumar, Dominique C. Saporito, Amina Kunovac, Quincy A. Hathaway, Breeanna Mintmier, Judy A. King, Rachel D. King, Vazhaikkurichi M. Rajendran, Aniello M. Infante, John M. Hollander, Roberta Leonardi
Summary: NUDT7 is an enzyme highly expressed in the liver and located in peroxisomes. It hydrolyzes CoA species, affecting peroxisomal lipid metabolism and the synthesis of bile acids. Deletion of Nudt7 gene alters the composition of the hepatic acyl-CoA pool and promotes the production of certain bile acid derivatives.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Salwa F. Mohamed, Dina H. Elnaggar, Mohamed A. Elsayed, Heba S. Abd-Elghaffar, Hana M. Hosny, Ashraf M. Mohamed, Eman M. H. Abbas, Thoraya A. Farghaly, Raafat A. El-Awady
Summary: A series of new nitrogenated heterocyclic compounds were successfully synthesized by reacting a chalcone derivative of 3-acetylindole with various reagents. The newly synthesized compounds were validated using elements analysis and spectral data. They exhibited promising anticancer activity and strong binding interaction with the active site of vascular endothelial growth factor-2 tyrosine kinase (VEGFR-2), indicating their potential as anticancer agents.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Huseyin Kekecmuhammed, Michael Tapera, Burak Tuzun, Senem Akkoc, Yunus Zorlu, Emin Saripinar
Summary: In this study, a new 4-oxothiazolidin-2-ylidene derivative bearing hydrazone moiety was synthesized, and its anticancer activity was evaluated. The compound was also investigated for its interactions with cancer-related proteins through molecular docking.
Article
Biochemistry & Molecular Biology
Zahra Nazemosadat-Arsanjani, Mahmoodreza Moein, Sammer Yousuf, Omidreza Firuzi, Muhammad Iqbal Choudhary
Summary: This study revealed that the structures of two previously described naphthoquinone abietane diterpenoids need revision and proposed some general rules based on 1D and 2D NMR for unambiguous determination of the ortho-/para-orientation of naphthalene containing abietanes. Furthermore, the structures of several other compounds were also revised accordingly, shedding light on the structure-activity relationship of quinone diterpenoids.
Article
Biochemistry & Molecular Biology
Shu Horikoshi, Wataru Saburi, Jian Yu, Hideyuki Matsuura, James R. Ketudat Cairns, Min Yao, Haruhide Mori
Summary: A study found that the enzyme AtBGlu42 in Arabidopsis thaliana can hydrolyze various beta-glucosides, cellooligosaccharides, and laminarioligosaccharides, in addition to hydrolyzing scopolin. Among the cellooligosaccharides, it shows the highest preference for cellotriose. The crystal structure analysis reveals that the Arg342 residue in AtBGlu42 has an unfavorable binding to cellooligosaccharides at subsite +3.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Masahiro Noshi, Daisuke Mori, Noriaki Tanabe, Takanori Maruta, Shigeru Shigeoka
Article
Biochemistry & Molecular Biology
Yuji Tanaka, Takahisa Ogawa, Takanori Maruta, Yuta Yoshida, Kazuharu Arakawa, Takahiro Ishikawa
Article
Multidisciplinary Sciences
Takuya Tomiyama, Kaeko Kurihara, Takahisa Ogawa, Takanori Maruta, Takumi Ogawa, Daisaku Ohta, Yoshihiro Sawa, Takahiro Ishikawa
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Takuya Tomiyama, Kyo Goto, Yuji Tanaka, Takanori Maruta, Takahisa Ogawa, Yoshihiro Sawa, Takuro Ito, Takahiro Ishikawa
Article
Biochemistry & Molecular Biology
Saki Shiroma, Mio Tanaka, Tomohiro Sasaki, Takahisa Ogawa, Kazuya Yoshimura, Yoshihiro Sawa, Takanori Maruta, Takahiro Ishikawa
Article
Multidisciplinary Sciences
Shun Tamaki, Kohei Nishino, Takahisa Ogawa, Takanori Maruta, Yoshihiro Sawa, Kazuharu Arakawa, Takahiro Ishikawa
Article
Plant Sciences
Yusuke Terai, Hiromi Ueno, Takahisa Ogawa, Yoshihiro Sawa, Atsuko Miyagi, Maki Kawai-Yamada, Takahiro Ishikawa, Takanori Maruta
Article
Plant Sciences
Takashi Kameoka, Takaya Okayasu, Kana Kikuraku, Takahisa Ogawa, Yoshihiro Sawa, Hiroshi Yamamoto, Takahiro Ishikawa, Takanori Maruta
Summary: Under high-light stress, chloroplast APXs and pH-dependent mechanisms interact to maintain plants' stability against oxidative stress. The PGR5-dependent mechanisms compensate for the lack of APXs, and the cyclic electron flow dependent on the NADH dehydrogenase-like complex may play a role in regulating this process.
Article
Plant Sciences
Tsubasa Sodeyama, Hitoshi Nishikawa, Kenji Harai, Daiki Takeshima, Yoshihiro Sawa, Takanori Maruta, Takahiro Ishikawa
Summary: Ascorbate is an important redox compound in plants, primarily synthesized through the d-mannose/l-galactose pathway in streptophytes. Physcomitrium patens was found to possibly possess both the d-mannose/l-galactose pathway and the d-galacturonate pathway. Moss ALase was characterized as a functional enzyme involved in ascorbate metabolism, with PpALase1 playing a significant role in dehydroascorbate degradation rather than ascorbate biosynthesis.
Article
Plant Sciences
Akane Hamada, Yasuhiro Tanaka, Takahiro Ishikawa, Takanori Maruta
Summary: Ascorbate is an essential antioxidant for plant growth and stress tolerance. Recent research shows that chloroplastic DHAR3, in collaboration with glutathione, plays a key role in accumulating ascorbate under high-light stress. This study highlights the importance of balancing stress intensity and recycling capacity for maintaining ascorbate pool size and tolerance to photooxidative stress.
Article
Biochemistry & Molecular Biology
Patrick Willems, Valerie Van Ruyskensvelde, Takanori Maruta, Robin Pottie, Alvaro D. Fernandez-Fernandez, Jarne Pauwels, Matthew A. Hannah, Kris Gevaert, Frank Van Breusegem, Katrien Van der Kelen
Summary: Alternative splicing is an important gene regulatory process in plants, and its inhibition can alleviate cell death and enhance tolerance to oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Md. Firose Hossain, Amit Kumar Dutta, Takamasa Suzuki, Tetsuya Higashiyama, Chiharu Miyamoto, Sumie Ishiguro, Takanori Maruta, Yuki Muto, Kohji Nishimura, Hideki Ishida, Mostafa Aboulela, Takushi Hachiya, Tsuyoshi Nakagawa
Summary: Targeted expression of bgl23-D is a useful tool for functional analysis of ATCSLDs. The bgl23-D mutant in Arabidopsis affects the bgl23-D gene, leading to abnormal division of guard mother cells and formation of bagel-shaped stomata. By expressing bgl23-D in specific cells and tissues, different phenotypes can be observed, such as cytokinesis defects, pollen shape defects, and increased growth.
Review
Biochemistry & Molecular Biology
Takanori Maruta
Summary: Plants store high concentrations of ascorbate, especially in their leaves, which acts as an excellent antioxidant and photoprotectant. The d-mannose/l-galactose pathway is responsible for ascorbate biosynthesis in plants, which is facilitated by light intensity and requires photosynthesis. The activation of the rate-limiting enzyme GGP by light and photosynthesis plays a critical role in regulating ascorbate pool size. Ascorbate itself also regulates its biosynthesis by repressing GGP translation in a dose-dependent manner.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Takumi Iwagami, Takahisa Ogawa, Takahiro Ishikawa, Takanori Maruta
Summary: Redox homeostasis is crucial for plant acclimation to nutrient-deficient conditions. This study investigated the effects of nutrient deficiencies on antioxidant systems in Arabidopsis thaliana and found that nitrogen starvation increased ascorbate content. However, there were no phenotypic differences between wild type and ascorbate-deficient mutants under nitrogen starvation. Under high-light stress, the mutants experienced more severe photoinhibition than the wild type, but the same extent of photoinhibition was observed for both wild type and mutants when high-light stress and nitrogen starvation were combined.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Plant Sciences
Ana Fernandez, Nick Vangheluwe, Ke Xu, Joris Jourquin, Lucas Alves Neubus Claus, Stefania Morales-Herrera, Boris Parizot, Hugues De Gernier, Qiaozhi Yu, Andrzej Drozdzecki, Takanori Maruta, Kurt Hoogewijs, Willem Vannecke, Brenda Peterson, Davy Opdenacker, Annemieke Madder, Zachary L. Nimchuk, Eugenia Russinova, Tom Beeckman