STUbLs in chromatin and genome stability

Sumoylation of MDC1 is important for proper DNA damage response

(2012) Kuntian Luo et al.   EMBO JOURNAL

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

Surrogate Genetics and Metabolic Profiling for Characterization of Human Disease Alleles

(2012) J. A. Mayfield et al.   GENETICS

The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult

(2012) Avgi Tsolou et al.   IUBMB LIFE

Acute promyelocytic leukemia, arsenic, and PML bodies

(2012) Hugues de Thé et al.   JOURNAL OF CELL BIOLOGY

Extensive DNA Damage-Induced Sumoylation Contributes to Replication and Repair and Acts in Addition to the Mec1 Checkpoint

(2012) Catherine A. Cremona et al.   MOLECULAR CELL

Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin

(2012) F. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax

(2011) K. A. Fryrear et al.   BLOOD

The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks

(2011) Caitlin E. Cook et al.   CELL CYCLE

Elg1, the major subunit of an alternative RFC complex, interacts with SUMO-processing proteins

(2011) Oren Parnas et al.   CELL CYCLE

Nuclear organization in genome stability: SUMO connections

(2011) Shigeki Nagai et al.   CELL RESEARCH

The Importance of Humanized Yeast to Better Understand the Role of Bcl-2 Family in Apoptosis: Finding of Novel Therapeutic Opportunities

(2011) Rui D. Silva et al.   CURRENT PHARMACEUTICAL DESIGN

The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis

(2011) K. C. Barry et al.   DEVELOPMENT

Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression

(2011) Mona Abed et al.   EMBO JOURNAL

Purification and identification of endogenous polySUMO conjugates

(2011) Roland Bruderer et al.   EMBO REPORTS

The Essential Ubc4/Ubc5 Function in Yeast Is HECT E3-dependent, and RING E3-dependent Pathways Require Only Monoubiquitin Transfer by Ubc4

(2011) Kate E. Stoll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay of Posttranslational Modifications in Sp1 Mediates Sp1 Stability during Cell Cycle Progression

(2011) Yi-Ting Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Desumoylation of the Endoplasmic Reticulum Membrane VAP Family Protein Scs2 by Ulp1 and SUMO Regulation of the Inositol Synthesis Pathway

(2011) R. Felberbaum et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA Repair and Global Sumoylation Are Regulated by Distinct Ubc9 Noncovalent Complexes

(2011) J. Prudden et al.   MOLECULAR AND CELLULAR BIOLOGY

The Swi2–Snf2-like protein Uls1 is involved in replication stress response

(2011) Magdalena Cal-Bąkowska et al.   NUCLEIC ACIDS RESEARCH

Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control

(2011) M. H. Tatham et al.   Science Signaling

SUMO playing tag with ubiquitin

(2011) Gerrit J.K. Praefcke et al.   TRENDS IN BIOCHEMICAL SCIENCES

SUMO-Targeted Ubiquitin Ligase, Rad60, and Nse2 SUMO Ligase Suppress Spontaneous Top1–Mediated DNA Damage and Genome Instability

(2011) Johanna Heideker et al.   PLoS Genetics

RING domain dimerization is essential for RNF4 function

(2010) Chu Wai Liew et al.   BIOCHEMICAL JOURNAL

The ubiquitous role of ubiquitin in the DNA damage response

(2010) Abdallah Al-Hakim et al.   DNA REPAIR

SUMO functions in constitutive transcription and during activation of inducible genes in yeast

(2010) E. Rosonina et al.   GENES & DEVELOPMENT

SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor

(2010) Y. Xie et al.   GENES & DEVELOPMENT

Degradation of the Saccharomyces cerevisiae Mating-Type Regulator  1: Genetic Dissection of Cis-determinants and Trans-acting Pathways

(2010) C. E. Nixon et al.   GENETICS

Genetic Evidence That Polysumoylation Bypasses the Need for a SUMO-Targeted Ub Ligase

(2010) J. R. Mullen et al.   GENETICS

The SUMO protease SENP6 is essential for inner kinetochore assembly

(2010) Debaditya Mukhopadhyay et al.   JOURNAL OF CELL BIOLOGY

A Novel Mechanism for SUMO System Control: Regulated Ulp1 Nucleolar Sequestration

(2010) Y. Sydorskyy et al.   MOLECULAR AND CELLULAR BIOLOGY

Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies

(2010) Marie-Claude Geoffroy et al.   MOLECULAR BIOLOGY OF THE CELL

Swi2/Snf2-Related Translocases Prevent Accumulation of Toxic Rad51 Complexes during Mitotic Growth

(2010) Parisha P. Shah et al.   MOLECULAR CELL

Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen

(2010) X. V. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

(2009) Nadine Martin et al.   EMBO JOURNAL

Quality Control of a Transcriptional Regulator by SUMO-Targeted Degradation

(2009) Z. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Signaling Initiates a Dynamic Interplay between Sumoylation and Ubiquitination To Regulate the Activity of the Transcriptional Activator PEA3

(2009) B. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Oestrogen receptors and small nuclear ring finger protein 4 (RNF4) in malignant ovarian germ cell tumours

(2009) Jonna Salonen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Global Map of SUMO Function Revealed by Protein-Protein Interaction and Genetic Networks

(2009) Taras Makhnevych et al.   MOLECULAR CELL

Chromosome-wide Rad51 Spreading and SUMO-H2A.Z-Dependent Chromosome Fixation in Response to a Persistent DNA Double-Strand Break

(2009) Marian Kalocsay et al.   MOLECULAR CELL

Specific pathways prevent duplication-mediated genome rearrangements

(2009) Christopher D. Putnam et al.   NATURE

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α

(2009) Martijn van Hagen et al.   NUCLEIC ACIDS RESEARCH

SUMO Mediates Interaction of Ebp2p, the Yeast Homolog of Epstein-Barr Virus Nuclear Antigen 1-Binding Protein 2, with a RING Finger Protein Ris1p

(2008) Chiharu SHIRAI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Arsenic trioxide stimulates SUMO-2/3 modification leading to RNF4-dependent proteolytic targeting of PML

(2008) Stefan R. Weisshaar et al.   FEBS LETTERS

The Ubiquitin-Proteasome System Is a Key Component of the SUMO-2/3 Cycle

(2008) Joost Schimmel et al.   MOLECULAR & CELLULAR PROTEOMICS

Deficient SUMO Attachment to Flp Recombinase Leads to Homologous Recombination-dependent Hyperamplification of the Yeast 2 μm Circle Plasmid

(2008) Ling Xiong et al.   MOLECULAR BIOLOGY OF THE CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

The prevalence of folate-remedial MTHFR enzyme variants in humans

(2008) N. J. Marini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

(2008) S. Nagai et al.   SCIENCE

A SIM-ultaneous role for SUMO and ubiquitin

(2008) J. Jefferson P. Perry et al.   TRENDS IN BIOCHEMICAL SCIENCES