Article
Cardiac & Cardiovascular Systems
Yali Zhao, Nicholas A. James, Ashraf R. Beshay, Eileen E. Chang, Andrew Lin, Faiza Bashar, Abram Wassily, Binh Nguyen, Thao P. Nguyen
Summary: This study aimed to define zebrafish ventricular electrical gradients shaping QRS complex and T wave patterns at baseline and under oxidative stress. The research found that zebrafish and human ventricular electrocardiographic patterns are mirror images supported by opposite electrical gradients and that CaMKII inhibitor can protect zebrafish hearts from oxidative stress-induced disruption of electrical gradients.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Monika Gawalko, Arnela Saljic, Na Li, Issam Abu-Taha, Thomas Jespersen, Dominik Linz, Stanley Nattel, Jordi Heijman, Anke Fender, Dobromir Dobrev
Summary: Obesity is a significant contributing factor to atrial fibrillation (AF) by causing systemic changes and affecting different adipose tissue depots. Adipose tissue secretes various mediators that promote AF and cardiac remodeling. This review discusses the role of obesity-related factors, specific adipose tissue depots, and molecular mechanisms in AF, highlighting gaps in current knowledge and implications for clinical management.
CARDIOVASCULAR RESEARCH
(2023)
Article
Clinical Neurology
Guilherme L. Fialho, Trudy D. Pang, Wan Yee Kong, Anthony P. Tran, Calvin G. Yu, Ivo D. Rodriguez, Bruce D. Nearing, Jonathan W. Waks, Timothy R. Maher, John-Ross Clarke, Alyssa Shepherd, Andre D'Avila, Steven C. Schachter, Richard L. Verrier
Summary: Identification of epilepsy patients with increased risk for atrial fibrillation is crucial. The study found that epilepsy patients have P-wave heterogeneity levels comparable to atrial fibrillation patients, indicating possible structural changes and cardiac electrical instability in epilepsy.
Article
Geochemistry & Geophysics
Wenxin Kong, Handong Tan, Changhong Lin, Martyn Unsworth, Benjamin Lee, Miao Peng, Mao Wang, Tuo Tong
Summary: Electrical anisotropy is crucial in resistivity models for interpreting magnetotelluric observations. A new 3-D MT inversion algorithm has been developed to recover a 3-D resistivity model considering arbitrary electrical anisotropy, tested on synthetic and field data. The algorithm demonstrates limitations in resolving vertical resistivity components due to dominant horizontal current flow in MTs and highlights the importance of prior information in reducing uncertainty.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2021)
Article
Thermodynamics
Peng Zheng, Yucheng Xia, Tingwei Yao, Xu Jiang, Peiyao Xiao, Zexuan He, Desheng Zhou
Summary: This study investigates the interaction mechanisms between hydraulic fractures and natural fractures in fractured reservoirs, showing that hydraulic fractures with incipient propagation superiority are more likely to rapidly propagate and inhibit the continuous initiation of surrounding micro fractures. Natural fractures can deflect the propagation direction of hydraulic fractures by shielding and transmitting induced stress, ultimately affecting the complexity of fracture networks and improving fracturing effects.
Article
Cardiac & Cardiovascular Systems
Auriane C. Ernault, Arie O. Verkerk, Jason D. Bayer, Kedar Aras, Pablo Montanes-Agudo, Rajiv A. Mohan, Marieke Veldkamp, Mathilde R. Rivaud, Rosan de Winter, Makiri Kawasaki, Shirley C. M. van Amersfoorth, Eva R. Meulendijks, Antoine H. G. Driessen, Igor R. Efimov, Joris R. de Groot, Ruben Coronel
Summary: The accumulation of epicardial adipose tissue (EAT) is associated with cardiac arrhythmias, and the secretome of EATs has effects on cardiac electrophysiology. In this study, it was found that incubation with EATs decreases the expression of the potassium channel subunit Kcnj2 and the inward rectifier K+ current I-K1 in cardiomyocytes, leading to depolarization of the resting membrane potential. EATs also decrease the expression of connexin43 and alter electrical cell-cell coupling.
Review
Endocrinology & Metabolism
Marinela Couselo-Seijas, Moises Rodriguez-Manero, Jose R. Gonzalez-Juanatey, Sonia Eiras
Summary: This study highlights the important role of epicardial fat in the occurrence and maintenance of atrial fibrillation, emphasizing the pathophysiological mechanisms involved and preventive therapeutic strategies. The increase in volume and activity of epicardial fat may alter cardiac autonomic activity, making reducing adiposity and weight crucial for preventing atrial fibrillation.
Review
Biochemistry & Molecular Biology
Jieyun Bai, Yaosheng Lu, Yijie Zhu, Huijin Wang, Dechun Yin, Henggui Zhang, Diego Franco, Jichao Zhao
Summary: Atrial fibrillation (AF) is a common arrhythmia with genetic predispositions playing a major role in its development. Genetic variants near the PITX2 gene on chromosome 4q25 have been identified in association with AF populations. Computational models are useful for understanding the functional impacts of PITX2 and may lead to improved anti-AF therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jianan Zhao, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis displays significant clinical heterogeneity and personalized responsiveness to standard treatments, with understanding individual variation in cellular and molecular mechanisms being crucial for improving patient outcomes. Pathological heterogeneity derived from genetic, molecular, and cellular factors influences precision medicine and personalized treatment approaches for rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Environmental
Fan Chen, Beilei Fan, Chunlin Wang, Jin Qian, Bo Wang, Xin Tang, Zemin Qin, Yanlong Chen, Bin Liang, Wenzong Liu, Aijie Wang, Yin Ye, Yuheng Wang
Summary: This research reports an effective method of using microbes to reduce soluble hexavalent uranium to insoluble tetravalent uranium, and demonstrates that electro-stimulation significantly enhances this process. The study also reveals the importance of microbial community diversity and synthetic metabolism between bacteria in the electro-microbial-mediated uranium removal, which is beneficial for treating uranium-bearing wastewater.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Yanping Zhang, Alice Le Friec, Di Sun, Menglin Chen
Summary: The development of flexible electronics with adjustable performance offers a promising approach for treating cardiac diseases, overcoming the limitations of conventional electronic systems due to biomechanical mismatches. By exploring the natural flow behavior of polymer melt in Melt electrowriting (MEW), researchers created a fibrous mesh electrode with a sinusoidal anisotropic structure resembling the collagen fiber architecture in the heart. This anisotropic, stretchable electrode mesh demonstrated the ability to synchronize cardiomyocyte beating through its biomimetic viscoelastic behavior and fine-tuned electrical properties, offering great potential for cardiac repair.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Inga Andriule, Dalia Pangonyte, Asfree Gwanyanya, Dainius Karciauskas, Kanigula Mubagwa, Regina Macianskiene
Summary: The expression of magnesium-sensitive TRPM6 and TRPM7 ion channels in the heart and their upregulation in ischemic heart disease and atrial fibrillation suggest their possible role in cardiac atrial disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Alexander Drobyshevsky, Sylvia Synowiec, Ivan Goussakov, Jing Lu, David Gascoigne, Daniil P. Aksenov, Vasily Yarnykh
Summary: The purpose of this study was to validate novel, model-based MRI techniques (MPF and NODDI) against histological markers of myelination and microstructural maturation. The results showed that MPF accurately reflected the myelination rate in different brain regions, while NODDI overestimated axonal volume during early development, leading to inaccurate estimation of g-ratio.
Article
Biology
Jean Albert Laissue, Sebastien Barre, Stefan Bartzsch, Hans Blattmann, Audrey M. Bouchet, Valentin G. Djonov, David Haberthur, Ruslan Hlushchuk, Barbara Kaser-Hotz, Pierre Philippe Laissue, Geraldine LeDuc, Susanne Oswald Reding, Raphael Serduc
Summary: Microbeam radiation therapy (MBRT) is a safe alternative treatment for muzzle tumors in pets, according to a preclinical study. The study examined the effects of microplanar beamlets on the muzzle of rabbits and found that no radionecrosis occurred in facial bones, but high doses of radiation caused caries-like damage to incisor teeth. The study suggests that MBRT can be used to treat muzzle tumors without causing significant damage to normal teeth, bone, and soft tissues if the radiation is controlled within specific dose limits.
RADIATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Andrzej Steplewski, Jolanta Fertala, Ryan E. Tomlinson, Mark L. Wang, Allison Donahue, William V. Arnold, Michael Rivlin, Pedro K. Beredjiklian, Joseph A. Abboud, Surena Namdari, Andrzej Fertala
Summary: This study demonstrated that targeting collagen fibrillogenesis to limit arthrofibrosis has no negative impact on the quality of healing joint tissues and can actually accelerate tissue remodeling and alter collagen fibrils.
Article
Multidisciplinary Sciences
Ning Li, Anuradha Kalyanasundaram, Brian J. Hansen, Esthela J. Artiga, Roshan Sharma, Suhaib H. Abudulwahed, Katelynn M. Helfrich, Galina Rozenberg, Pei-Jung Wu, Stanislav Zakharkin, Sandor Gyorke, Paul M. L. Janssen, Bryan A. Whitson, Nahush A. Mokadam, Brandon J. Biesiadecki, Federica Accornero, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Jichao Zhao, Vadim V. Fedorov
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Joseph Yanni, Alicia D'Souza, Yanwen Wang, Ning Li, Brian J. Hansen, Stanislav O. Zakharkin, Matthew Smith, Christina Hayward, Bryan A. Whitson, Peter J. Mohler, Paul M. L. Janssen, Leo Zeef, Moinuddin Choudhury, Min Zi, Xue Cai, Sunil Jit R. J. Logantha, Shu Nakao, Andrew Atkinson, Maria Petkova, Ursula Doris, Jonathan Ariyaratnam, Elizabeth J. Cartwright, Sam Griffiths-Jones, George Hart, Vadim V. Fedorov, Delvac Oceandy, Halina Dobrzynski, Mark R. Boyett
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Elisa Ferraro, Lidia Pozhidaeva, David S. Pitcher, Catherine Mansfield, Jia Han Benjamin Koh, Catherine Williamson, Oleg Aslanidi, Julia Gorelik, Fu Siong Ng
SCIENTIFIC REPORTS
(2020)
Article
Cardiac & Cardiovascular Systems
Maria Petkova, Andrew J. Atkinson, Joseph Yanni, Luke Stuart, Abimbola J. Aminu, Alexandra D. Ivanova, Ksenia B. Pustovit, Connor Geragthy, Amy Feather, Ning Li, Yu Zhang, Delvac Oceandy, Filip Perde, Peter Molenaar, Alicia D'Souza, Vadim V. Fedorov, Halina Dobrzynski
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Physiology
Luca Soattin, Zoltan Borbas, Jane Caldwell, Brian Prendergast, Akbar Vohra, Yawer Saeed, Andreas Hoschtitzky, Joseph Yanni, Andrew Atkinson, Sunil Jit Logantha, Balint Borbas, Clifford Garratt, Gwilym Matthew Morris, Halina Dobrzynski
Summary: SAN ablation in goats led to the emergence of chronic SAP activity in 60% of treated animals. SAPs showed developmental changes over time and were located within the previously identified PNA in humans, indicating their potential role as the dominant pacemaker in SND. Therefore, SAP in goats represents a promising stable target for electrophysiological modifications in order to create a fully functional pacemaker.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Pietro Mesirca, Shu Nakao, Sarah Dalgas Nissen, Gabriella Forte, Cali Anderson, Tariq Trussell, Jue Li, Charlotte Cox, Min Zi, Sunil Logantha, Sana Yaar, Helena Cartensen, Isabelle Bidaud, Luke Stuart, Luca Soattin, Gwilym M. Morris, Paula A. da Costa Martins, Elizabeth J. Cartwright, Delvac Oceandy, Matteo E. Mangoni, Thomas Jespersen, Rikke Buhl, Halina Dobrzynski, Mark R. Boyett, Alicia D'Souza
Summary: The study found that atrioventricular block in athletes is mainly caused by electrical remodeling. Trained animals and mice showed atrioventricular node dysfunction, characterized by prolonged PR intervals and reduced expression of key ion channels. miRNAs such as miR-211-5p and miR-432 were identified as direct regulators of Ca(V)1.2 and HCN4.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Abimbola J. Aminu, Maria Petkova, Andrew J. Atkinson, Joseph Yanni, Alex D. Morris, Robert T. Simms, Weixuan Chen, Zeyuan Yin, Marcin Kuniewicz, Mateusz K. Holda, Vladislav S. Kuzmin, Filip Perde, Peter Molenaar, Halina Dobrzynski
Summary: The study identified key transcription factors (TFs) and cell markers in the sinus node (SN) that are significantly more expressed compared to the right atrial tissue (RA), which play a role in regulating ion channels and immune cells. Some TFs were predicted to regulate the expression of key ion channel HNC4, while cell markers were found to have complex interactions with these TFs.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Article
Veterinary Sciences
S. Nakao, A. J. Atkinson, T. Motomochi, D. Fukunaga, H. Dobrzynski
Summary: A 6-month-old female cat presented with complex cardiac anomalies including biatrial and biventricular dilation, with branching abnormalities in the aorta. The cat died of severe congestive heart failure, with postmortem diagnosis confirming the arterial trunk abnormalities through micro-computed tomography analysis. Micro-computed tomography proved to be a valuable tool for ex vivo diagnosis of complex cardiac anomalies in this case.
JOURNAL OF VETERINARY CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sunil Jit R. J. Logantha, Xue J. Cai, Joseph Yanni, Caroline B. Jones, Robert S. Stephenson, Luke Stuart, Gillian Quigley, Oliver Monfredi, Shu Nakao, Il-Young Oh, Tobias Starborg, Ashraf Kitmitto, Akbar Vohra, Robert C. Hutcheon, Antonio F. Corno, Jonathan C. Jarvis, Halina Dobrzynski, Mark R. Boyett, George Hart
Summary: Severe heart failure causes significant effects on Purkinje fibers, including dysfunction, impaired ventricular repolarization, and electrical remodeling, which may increase the risk of fatal arrhythmias in patients.
CIRCULATION-HEART FAILURE
(2021)
Article
Physiology
Marica Muffoletto, Ahmed Qureshi, Aya Zeidan, Laila Muizniece, Xiao Fu, Jichao Zhao, Aditi Roy, Paul A. Bates, Oleg Aslanidi
Summary: Atrial fibrillation is a common cardiac arrhythmia with high morbidity and mortality rates, and catheter ablation is a first-line treatment option with suboptimal success rates. Computational approaches, combining image-based modeling and deep learning classifiers, show promise in assisting with CA therapy selection.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Laila Muizniece, Adrian Bertagnoli, Ahmed Qureshi, Aya Zeidan, Aditi Roy, Marica Muffoletto, Oleg Aslanidi
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia, and catheter ablation (CA) is a treatment method with suboptimal success rate. Image-guided CA procedures have shown promise, but still lack functional information and require clinician interpretation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vladislav S. Kuzmin, Alexandra D. Ivanova, Tatiana S. Filatova, Ksenia B. Pustovit, Anastasia A. Kobylina, Andrew J. Atkinson, Maria Petkova, Yurij I. Voronkov, Denis Abramochkin, Halina Dobrzynski
Summary: Mir-133a-3p has effects on cardiac electrophysiology, inducing changes in membrane potential of cardiac myocytes, especially in the atrium with significant effects on calcium and outward currents.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Abimbola J. Aminu, Maria Petkova, Weixuan Chen, Zeyuan Yin, Vlad S. Kuzmin, Andrew J. Atkinson, Halina Dobrzynski
Summary: The study confirmed that miR-486-3p significantly downregulates Ca(v)1.3, Ca(v)3.1, and TPSAB1-mediated luciferase activity, while miR-938 only significantly downregulates TPSAB1-mediated luciferase activity. This suggests that miR-486-3p could be a potential therapeutic target for treating sinus node dysfunctions.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Claire Wilson, Min Zi, Matthew Smith, Munir Hussain, Alicia D'Souza, Halina Dobrzynski, Mark R. Boyett
Summary: Heart failure is associated with AV node dysfunction, and AV node dysfunction in heart failure is linked to increased mortality and hospitalization risk. This study investigated the causes of AV node dysfunction in heart failure by examining changes in the entire nodal transcriptome. The findings revealed that heart failure leads to AV node conduction slowing and dysfunction, as well as significant alterations in 3,077 transcripts (5.6% of the transcriptome). Various systems were affected, including downregulation of transcripts supporting AV node conduction and changes in transcripts related to the PR interval. Additionally, there was evidence of sarcomere remodeling, a shift from fatty acid to glucose metabolism, extracellular matrix remodeling, and dysregulation of transcription and translation machinery. The study also identified dysregulation of multiple intracellular signaling pathways, protein kinases, transcription factors, and immune response as potential causes of AV node remodeling. In conclusion, inflammation and extensive transcriptional remodeling underlie AV node dysfunction in heart failure.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Emman Asjad, Halina Dobrzynski
Summary: This article summarizes the role of miRNAs as biomarkers and their interactions with targets that affect cardiac health, and provides current therapeutic knowledge in a succinct manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)