Article
Biochemistry & Molecular Biology
Asfree Gwanyanya, Inga Andriule, Bogdan M. Istrate, Farjana Easmin, Kanigula Mubagwa, Regina Macianskiene
Summary: TRPM6 and TRPM7 proteins in the heart may be the molecular candidates for native cardiac Mg2+-sensitive channels, potentially influencing the duration of action potentials and having implications in arrhythmogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Julia Krause, Alexander Nickel, Alexandra Madsen, Hamish M. Aitken-Buck, A. M. Stella Stoter, Jessica Schrapers, Francisco Ojeda, Kira Geiger, Melanie Kern, Michael Kohlhaas, Edoardo Bertero, Patrick Hofmockel, Florian Huebner, Ines Assum, Matthias Heinig, Christian Mueller, Arne Hansen, Tobias Krause, Deung-Dae Park, Steffen Just, Dylan Aissi, Daniela Boernigen, Diana Lindner, Nele Friedrich, Khaled Alhussini, Constanze Bening, Renate B. Schnabel, Mahir Karakas, Licia Iacoviello, Veikko Salomaa, Allan Linneberg, Hugh Tunstall-Pedoe, Kari Kuulasmaa, Paulus Kirchhof, Stefan Blankenberg, Torsten Christ, Thomas Eschenhagen, Regis R. Lamberts, Christoph Maack, Justus Stenzig, Tanja Zeller
Summary: Long-chain acyl-carnitines, specifically C18:1AC, have been found to be potential arrhythmogenic metabolites. This metabolite has biphasic effects on cardiac electrophysiology and metabolism, and has the potential to serve as a circulating biomarker for predicting risk of atrial fibrillation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Diana Andrada Irimie, Adela Viviana Sitar-Taut, Bogdan Caloian, Florina Fringu, Gabriel Cismaru, Radu Rosu, Mihai Puiu, Ioan Alexandru Minciuna, Gelu Simu, Dumitru Zdrenghea, Dana Pop
Summary: Catheter ablation for women with ischemic heart disease and atrial fibrillation is performed later and involves trying more antiarrhythmic drugs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Liangyu Hu, Zhengkun Wang, Claudia Carmone, Jaap Keijer, Deli Zhang
Summary: Atrial fibrillation (AF) and ischemic heart disease (IHD) are common cardiac diseases with significant impact on cardiovascular health. Oxidative DNA damage may play a major role in promoting the development of these diseases, with antioxidants and DNA repair enzymes being potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Anna Rossig, Kerstin Hill, Wolfgang Noerenberg, Sebastian Weidenbach, Susanna Zierler, Michael Schaefer, Thomas Gudermann, Vladimir Chubanov
Summary: This study identified three small synthetic molecules, iloperidone, ifenprodil, and VER155008, that selectively manipulate TRPM6 and TRPM7 currents.
Article
Cardiac & Cardiovascular Systems
Tiberiu A. Pana, Mohamed O. Mohamed, Allan B. Clark, Eoin Fahy, Mamas A. Mamas, Phyok. Myint
Summary: This study examined the impact of atrial fibrillation and heart failure on the prognosis of patients with acute ischemic stroke, as well as the effects of revascularization therapies on their outcomes. The results indicated that both atrial fibrillation and heart failure were associated with increased in-hospital mortality, with a greater impact seen in patients with both conditions. Additionally, it was found that revascularization therapies significantly improved outcomes in these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel E. Singer, Paul D. Ziegler, Jodi L. Koehler, Shantanu Sarkar, Rod S. Passman
Summary: This study aimed to define the temporal association between episodes of atrial fibrillation (AF) and stroke in patients with cardiac implantable electronic devices (CIEDs). The results showed that the risk of stroke was highest within 5 days of an episode of AF lasting 5.5 hours or more. The findings support trials of time-limited anticoagulation for patients with infrequent multi-hour episodes of AF and rigorous, continuous rhythm monitoring.
Article
Physiology
Dorothee Jakob, Alexander Klesen, Elisa Darkow, Fabian A. Kari, Friedhelm Beyersdorf, Peter Kohl, Ursula Ravens, Remi Peyronnet
Summary: Cardiac fibroblasts, despite not generating action potentials, can influence cardiac electrophysiology through electrical coupling with cardiomyocytes and fibrosis. This study investigated the electrophysiological phenotype of human atrial fibroblasts from patients with sinus rhythm or atrial fibrillation, revealing differential channel expression between the two.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Ankit Maheshwari, Faye L. Norby, Riccardo M. Inciardi, Wendy Wang, Michael J. Zhang, Elsayed Z. Soliman, Alvaro Alonso, Michelle C. Johansen, Rebecca F. Gottesman, Scott D. Solomon, Amil M. Shah, Lin Yee Chen
Summary: This study evaluated the association between left atrial function and size and ischemic stroke, and determined whether these measures could improve the accuracy of stroke prediction using CHA(2)DS(2)-VASc score variables. The results showed that left atrial size and function were associated with ischemic stroke, and the cumulative incidence rates of severe left atrial enlargement were 2.99%, 3.18%, and 1.99% for left atrial reservoir, conduit, and contractile strain, respectively. Adding left atrial function measures to CHA(2)DS(2)-VASc score variables improved stroke prediction accuracy.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Yi Ching Chen, Aleksandr Voskoboinik, Andre La Gerche, Thomas H. Marwick, Julie R. McMullen
Summary: Studies have extensively researched the differences between physiological and pathological ventricular hypertrophy, while the differences between physiological and pathological atrial enlargement remain poorly understood.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Clinical Neurology
Laurent Fauchier, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Pascal Spiesser, Bertrand Pierre, Nicolas Clementy, Anne Bernard, Dominique Babuty, Gregory Y. H. Lip
Summary: Patients with hypertrophic cardiomyopathy (HCM) have a high risk of ischemic stroke (IS), particularly if they also have atrial fibrillation (AF). This French study aimed to improve risk stratification by developing a French HCM score for identifying HCM patients at higher risk of stroke. The study found that the French HCM score had good accuracy and clinical usefulness in predicting stroke in HCM patients.
Article
Medicine, General & Internal
Ebenezer Oni, Oluseye Ogunmoroti, Norrina Allen, Mouaz H. A-Mallah, Ron Blankstein, Seth S. Martin, Irfan Zeb, Mary Cushman, Parag H. Joshi, Matthew J. Budoff, Michael J. Blaha, Roger S. Blumenthal, Emir Veledar, Khurram Nasir
Summary: The study found that a more favorable cardiovascular health score was associated with a lower prevalence of NAFLD. This may suggest a potential of Life's Simple 7 in the prevention of liver disease.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Amy Groenewegen, Victor W. Zwartkruis, Betul Cekic, Rudolf. A. de Boer, Michiel Rienstra, Arno W. Hoes, Frans H. Rutten, Monika Hollander
Summary: This study conducted a dynamic longitudinal cohort study using primary care databases and found a clear association between diabetes and incidence of major chronic progressive heart diseases, notably heart failure with a more than twice increased risk.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dorothee Jakob, Alexander Klesen, Benoit Allegrini, Elisa Darkow, Diana Aria, Ramona Emig, Ana Simon Chica, Eva A. Rog-Zielinska, Tim Guth, Friedhelm Beyersdorf, Fabian A. Kari, Susanne Proksch, Stephane N. Hatem, Matthias Karck, Stephan R. Kunzel, Helene Guizouarn, Constanze Schmidt, Peter Kohl, Ursula Ravens, Remi Peyronnet
Summary: The study found that human atrial fibroblasts contain at least two types of ion channels activated during stretch: Piezol and BKca. Sustained atrial fibrillation is associated with increased Piezol and decreased BKca activity, indicating differential regulation of these channels.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jordana I. Borges, Malka S. Suster, Anastasios Lymperopoulos
Summary: The regulator of G protein signaling (RGS) proteins are essential for terminating G protein signals elicited by GPCRs. They play crucial roles in the regulation of cardiac function and homeostasis and are involved in heart failure and atrial fibrillation. Numerous studies have shown the importance of RGS proteins in cardiac normal homeostasis as well as pathophysiology, with RGS4 being selectively upregulated in human HF and implicated in protection against AFib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)