Article
Biochemistry & Molecular Biology
Chie Takano, Takuma Takano, Makoto Masumura, Ryuichi Nakamura, Shuichi Koda, Hiroki Bochimoto, Shigetaka Yoshida, Yoshio Bando
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS, where relapsing-remitting MS (RRMS) is the most common type. The mechanisms of relapse and remission in MS are not fully understood. Research on SJL mice immunized with proteolipid protein (PLP) showed that some mice developed a resistance to relapsing EAE after initial symptoms similar to relapsing EAE. Myelin morphology examination revealed that resistant mice had milder EAE symptoms, less CNS inflammation, demyelination, and myelin structure abnormalities compared to RR-EAE mice. This study highlights the role of the neuroinflammation-induced degenerating 21 kDa isoform of myelin basic protein (MBP) in the development of abnormal myelin during MS relapse.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Tuan A. Nguyen, Henry L. Puhl, Kirk Hines, Daniel J. Liput, Steven S. Vogel
Summary: The regulation and modulation of synaptic functions rely on a coordinated choreography of protein conformational changes and interactions, which are influenced by intracellular calcium dynamics. By using time-lapse Forster resonance energy transfer, we can study the dynamics of both conformational changes and protein-protein interactions simultaneously under physiological conditions.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Agata Zienowicz, Vladimir V. Bamm, Kenrick A. Vassall, George Harauz
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Vladimir V. Bamm, Danielle K. Lanthier, Erin L. Stephenson, Graham S. T. Smith, George Harauz
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Article
Biochemistry & Molecular Biology
Meaghan E. Ward, Emily Ritz, Mumdooh A. M. Ahmed, Vladimir V. Bamm, George Harauz, Leonid S. Brown, Vladimir Ladizhansky
JOURNAL OF BIOMOLECULAR NMR
(2015)
Article
Biochemistry & Molecular Biology
Kenrick A. Vassall, Vladimir V. Bamm, Andrew D. Jenkins, Caroline J. Velte, Daniel R. Kattnig, Joan M. Boggs, Dariush Hinderberger, George Harauz
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2016)
Review
Endocrinology & Metabolism
Vladimir V. Bamm, Arielle M. Geist, George Harauz
METABOLIC BRAIN DISEASE
(2017)
Article
Biochemistry & Molecular Biology
Vladimir V. Bamm, Mary E. L. Henein, Shannon L. J. Sproul, Danielle K. Lanthier, George Harauz
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Kyrylo Bessonov, Kenrick A. Vassall, George Harauz
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2017)
Editorial Material
Biochemical Research Methods
George Harauz
Article
Chemistry, Multidisciplinary
Katharina Widder, Jennica Traeger, Andreas Kerth, George Harauz, Dariush Hinderberger
Article
Multidisciplinary Sciences
Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Carla L. Coackley, Kayla M. Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D. Mosser, Stuart A. Lipton, George Harauz, Scott D. Ryan
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Katharina Widder, George Harauz, Dariush Hinderberger
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Cell Biology
Jennica Traeger, Katharina Widder, Andreas Kerth, George Harauz, Dariush Hinderberger
Article
Biophysics
Justin Medeiros, Vladimir V. Bamm, Catherine Jany, Carla Coackley, Meaghan E. Ward, George Harauz, Scott D. Ryan, Vladimir Ladizhansky
Summary: Alpha-synuclein is a small presynaptic protein believed to be crucial in Parkinson's disease pathogenesis. Recent evidence suggests its interaction with mitochondrial membranes and a unique anionic phospholipid. Through NMR experiments, it was found that alpha-syn associated with specific lipid vesicles exhibited more favorable dynamic properties for conducting three-dimensional experiments.
BIOMOLECULAR NMR ASSIGNMENTS
(2021)
Article
Cell Biology
Morgan G. Stykel, Kayla M. Humphries, Evelyn Kamski-Hennekam, Brodie Buchner-Duby, Natalie Porte-Trachsel, Tammy Ryan, Carla L. Coackley, Vladimir V. Bamm, George Harauz, Scott D. Ryan
Summary: Neuronal loss in Parkinson's disease is linked to impaired proteostasis and accumulation of alpha-syn microaggregates in dopaminergic neurons, which promote the spread of pathology between synaptically linked neurons. Using human pluripotent stem cell models, researchers found that SNCA mutant neurons accumulate alpha-syn deposits that can lead to the seeding of alpha-syn pathology. This suggests a new mechanism for the spread of synucleinopathy in PD.
Article
Cell & Tissue Engineering
Nishanth Lakshman, Clara Bourget, Ricky Siu, Vladimir V. Bamm, Wenjun Xu, George Harauz, Cindi M. Morshead
Summary: The study demonstrates that myelin basic protein (MBP) can regulate neural precursor cell (NPC) behavior and that the inhibitory effects of MBP on NPCs are regionally distinct. The heat-labile protein released by spinal cord niche cells plays a key role in mediating the inhibitory actions of MBP on NPCs. These findings highlight the importance of MBP and regionally distinct microenvironments in regulating NPC behavior, with implications for stem cell-based regenerative strategies.