Substitutions mimicking deimination and phosphorylation of 18.5-kDa myelin basic protein exert local structural effects that subtly influence its global folding

Title

Substitutions mimicking deimination and phosphorylation of 18.5-kDa myelin basic protein exert local structural effects that subtly influence its global folding

Authors

Keywords

Citrullination/deimination, Förster (fluorescence) resonance energy transfer (FRET), Intrinsically-disordered protein, Molecular recognition fragment (MoRF), Myelin basic protein (MBP), Protein folding intermediate, Amphipathic α-helix, Calmodulin, Cathepsin D, Circular dichroism (CD) spectroscopy, DEER spectroscopy, Phosphorylation

Journal

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Volume 1858, Issue 6, Pages 1262-1277

Publisher

Elsevier BV

Online

2016-02-20

DOI

10.1016/j.bbamem.2016.02.024