Article
Chemistry, Organic
Mehdi Fallah-Mehrjardi, Mahdieh Shirzadi, Sayed Hossein Banitaba
Summary: An efficient and straightforward procedure for the synthesis of 2-amino-3-cyano-4H-pyrans via one-pot three-component reaction has been developed. A new nanomagnetite-supported organocatalyst has been used in aqueous media. The catalyst can be easily separated and reused without significant decrease in activity.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Applied
Fatemeh Sameri, Mohammad Ali Bodaghifard, Akbar Mobinikhaledi
Summary: In this study, a Zn(II) Schiff base was covalently anchored onto the surface of CaO@SiO2 nanoparticles. The organic-inorganic hybrid nanostructure showed excellent catalytic activity for the green synthesis of 4H-pyran derivatives, with high yields obtained. Additionally, the material exhibited stability and high performance under reaction conditions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Sepideh Bibak, Ahmad Poursattar Marjani
Summary: In this research, a magnetically separable heterogeneous nanocatalyst named Fe3O4@CPTMO@dithizone-Ni was synthesized using a core-shell procedure. The catalyst showed high stability and recyclability with excellent performance in the green synthesis of 4H-benzo[h]chromenes. It possesses advantages such as easy separation, cost-effectiveness, and environmental friendliness.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Organic
Mehdi Fallah-Mehrjardi, Maryam Zare
Summary: In this article, a green and recoverable heterogeneous phase-transfer catalyst was synthesized and its catalytic performance in the synthesis of 2-amino-3-cyano-4H-pyrans was investigated. The results showed that the catalyst exhibited mild conditions, simple operation, high yield, and reusability.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Engineering, Environmental
Yanfei Zhang, Haonan Zhang, Jinxin Liu, Minli Tao, Ning Ma, Wenqin Zhang
Summary: A new fiber-based asymmetric catalyst PANQNF, formed by the combination of polyacrylonitrile fiber and quinine, exhibits advantages such as easy preparation, high activity, high enantioselectivity, wide reaction temperature range, simple separation, and good recyclability. It shows great potential for industrial application.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Padmini Gupta, Swati Rani, Digvijay Sah, Bholey Surabhi, Javaid Shabir, Bholey Singh, Balaram Pani, Subho Mozumdar
Summary: In this study, magnetic nanoparticles functionalized with basic ionic liquid based on immobilized Fe3O4 @SiO2 (FS) and 1,4-diazabicyclo[2.2.2]octane (DABCO) were synthesized. The synthesized nanocomposite was characterized using various physicochemical and morphological techniques. It was found to be a thermally stable and highly cost-effective catalyst for green base-promoted organic transformations, resulting in excellent yields in short reaction times. Additionally, the magnetic nanocomposite could be easily recovered and recycled multiple times without significant loss in performance. (c) 2022 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Jing Chen, Daxin Shi, Qin Wu, Kangcheng Chen, Yaoyuan Zhang, Xiyan Xu, Hansheng Li
Summary: In this study, a magnetically-separable quasi-homogeneous magnetic brush-type ionic liquid polymer was synthesized using magnetic polystyrene microspheres as the core and brush-type alkaline imidazolium ionic liquid polymers as the covalent bonds. The synthesized polymer demonstrated high catalytic activity and stability in Knoevenagel-Michael tandem reactions and transesterification tandem reactions. Magnetic separation facilitated the effortless recovery and reutilization of the polymer, indicating promising potential for eco-friendly procedures.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Organic
Shaily Sharma, Mahesh Meena, Himanshu Sharma, Dinesh Kumar Yadav, Atul Tiwari, Ved Prakash Verma
Summary: In this study, 17 examples of 2-Amino-3-cyano-4H-chromene derivatives were prepared via a one-pot three components domino Knoevenagel-Michael condensation reaction. The reaction was conducted under ultrasound irradiation using Fe3O4-supported sulfonated graphene oxide as a green and magnetically separable nanocatalyst. The synthesis protocol showed high atom economy, excellent yields, and other advantages such as short reaction time and recyclability of the catalyst. In-silico studies were conducted to analyze the docking interactions of the compounds with selected proteins, and ADME and toxicity analysis were also performed.
SYNTHETIC COMMUNICATIONS
(2022)
Review
Chemistry, Organic
Rana Chatterjee, Swadhapriya Bhukta, Rambabu Dandela
Summary: Ionic liquids have gradually become an alternative finding in advanced research, playing a crucial role in conveying greener solvents or catalysts. Various methods have been developed using different types of ionic liquids to synthesize 4H-chromene derivatives, including those with pharmacological and biological activity like the 2-amino-3-cyano-4H-chromene moiety. Ionic liquids have a wide range of applications in multi-component synthesis, offering a sustainable and greener approach.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Hadi Kargar, Mehdi Fallah-Mehrjardi, Khurram Shahzad Munawar
Summary: A novel dioxomolybdenum(VI) complex was successfully synthesized, and its catalytic potential for the synthesis of substituted 4H-pyrans was explored. The new method offers advantages such as shorter reaction time, higher yield, and simplicity in operation.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Aiborlang Thongni, Pynskhemborlang T. Phanrang, Arup Dutta, Rishanlang Nongkhlaw
Summary: Using sodium citrate as a catalyst, this method facilitates a one-pot three-component reaction at room temperature, offering advantages such as short reaction time, use of eco-friendly solvents, and ease of operation. This approach holds significant promise from a green chemistry perspective.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Janan Metghalchi Langroudi, Masoumeh Mazloumi, Hossein Taherpour Nahzomi, Farhad Shirini, Hassan Tajik
Summary: A suitable dicationic molten salt has been characterized using various analysis methods. The accurate structure of the catalyst has been determined through energy calculation and NMR chemical shift comparison. Its application in the synthesis of specific compounds has also been investigated.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Dikin Patel, Komal A. Trivedi, Himanshu Srivastava, Sanjeev R. Kane, Chetan K. Modi
Summary: In this study, we fabricated a novel nano-catalyst FeNPs/DETA@rGO with a dual activation mechanism. The catalyst exhibits excellent characteristics in terms of both base and acid properties, enabling efficient catalysis of carbon-carbon bond formation. Moreover, the catalyst showed good stability even after multiple cycles of recycling.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Organic
I. V. Dyachenko, V. D. Dyachenko, P. V. Dorovatovskii, V. N. Khrustalev, V. G. Nenajdenko
Summary: The multicomponent condensation of aldehydes, malononitrile derivatives, 1,3-dicarbonyl compounds, and alkyl halides was investigated, resulting in the formation of functionally substituted fused 2-amino-4H-pyrans through the initiation of the Knoevenagel reaction. The structures of a few products were determined by X-ray diffraction (XRD) analysis.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Zahra Akhlaghi, Mohammad R. Naimi-Jamal, Leila Panahi, Mohammad G. Dekamin, Bahareh Farasati Far
Summary: 4H-pyrans with ketone and aldehyde groups were synthesized through a mechanochemical multicomponent reaction (MCR) using an amine-functionalized metal-organic framework (MOF) Cu2(NH2-BDC)2(DABCO) as a heterogeneous catalyst, resulting in good to excellent yields.
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)