Article
Agronomy
Tengfei Zhan, Xin Guo, Lu Ma, Shengyong Mao, Dengpan Bu
Summary: This study evaluated the effect of biotin and leucine on the synthesis of odd- and branched-chain fatty acids (OBCFA) in ruminants. The results showed that biotin promoted dry matter degradation, while leucine increased the concentration of branched-chain volatile fatty acids and valerate. In conclusion, biotin and leucine can be effective nutrition strategies to promote OBCFA synthesis.
Article
Chemistry, Multidisciplinary
Weibo Wang, Qingpeng Wei, Jiayuan Zhang, Meiqi Zhang, Chuchen Wang, Renyu Qu, Yuan Wang, Guangfu Yang, Jing Wang
Summary: This study developed a genetically encoded fluorescent sensor for ratiometric quantification of LCACoAs in living cells, demonstrating conformational changes of LCACoA molecules and real-time monitoring. The research also revealed the impact of disruptions in ACSL enzymes and ACBP genes on the levels and distribution of LCACoAs in cytosol and mitochondria.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Ravi R. Sonani, Artur Blat, Grzegorz Dubin
Summary: This study solved the crystal structures of human ACOX1a, revealing its homodimeric form and the binding of two FAD molecules at the active site. It also found that the substrate binding cleft of ACOX1a is wider compared to other fatty acid oxidation enzymes. Furthermore, the study analyzed the impact of mutations causing dysfunctionality of ACOX1a on its structure and function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Yuxun Zhang, Eric Goetzman
Summary: Mitochondrial trifunctional protein (TFP) plays a crucial role in chain-shortening long-chain fatty acids within the mitochondria. Despite being heavily modified by acetyllysine and succinyllysine post-translational modifications, the functional significance of these modifications on TFP remains unclear. Research suggests that TFP in the membrane-bound state may be protected from lysine acylation, which could impact its enzymatic activity.
Article
Genetics & Heredity
Barbara J. Henriques, Rikke Katrine Jentoft Olsen, Claudio M. Gomes, Peter Bross
Summary: Electron transfer flavoprotein (ETF) is an enzyme essential in cellular metabolism, transferring electrons from various enzymes to the respiratory chain to provide reducing power for cells. ETF relays electrons to the respiratory chain by direct transfer between enzyme-bound flavins, promoting electron transport.
Review
Nutrition & Dietetics
Chuang Du, Wen-Jie Liu, Jing Yang, Shan-Shan Zhao, Hui-Xin Liu
Summary: This article introduces the importance of branched-chain amino acids in human physiology and their association with various metabolic disorders. It also discusses the relationship between the alteration of the branched-chain amino acid catabolism enzyme BCKDK and related diseases. Additionally, the article highlights the interaction between branched-chain amino acids and the gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Review
Cell Biology
Michaela E. Trautman, Nicole E. Richardson, Dudley W. Lamming
Summary: The proportion of people suffering from age-related diseases is increasing worldwide. Recent research has shown that low protein diets, particularly those low in branched-chain amino acids (BCAAs), can reduce mortality and promote metabolic health and extended lifespan in both humans and rodents. This article discusses the emerging evidence that BCAAs play a crucial role in healthy metabolism and longevity, and explores the physiological and molecular mechanisms behind the benefits of restricting dietary BCAAs. The findings suggest that the quality of protein, specifically the composition of dietary protein, may be a previously overlooked factor in metabolic dysfunction and reducing dietary BCAAs could be a promising new approach to delaying and preventing age-related diseases.
Article
Agriculture, Dairy & Animal Science
K. E. Mitchell, C. Lee, M. T. Socha, D. H. Kleinschmit, J. L. Firkins
Summary: This study assessed the uptake of branched-chain volatile fatty acids (BCVFA) for branched-chain amino acid (BCAA) synthesis in bacteria. It was found that BCVFA uptake for BCAA synthesis was higher in high forage diets compared to low forage diets. The addition of corn oil decreased the usage of BCVFA for BCAA synthesis in high forage diets. The findings suggest that BCVFA supplementation can benefit the flow of BCAA and other amino acids in dairy cattle.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Neil P. J. Price, Michael A. Jackson, Trina M. Hartman, John P. Bannantine, Todd A. Naumann, Karl E. Vermillion, Aaron A. Koch, Paul D. Kennedy
Summary: Tunicamycins (TUNs) are natural products derived from Streptomyces and have the ability to block protein N-glycosylation in eukaryotes or cell wall biosynthesis in bacteria. Modified or synthetic TUN analogues can serve as novel antibacterial agents with unique modes of action. A small molecule screen has identified several novel TUN N-acyl variants that can be produced under fermentation, expanding the structural diversity of this class of compounds for potential medical and agricultural applications.
ACS CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yongjie Liu, Zihan Liu, Huishu Zhang, Shaohua Yuan, Yanmei Li, Tianbao Zhang, Jianfang Bai, Liping Zhang
Summary: This study systematically analyzed the wheat LACS gene family and identified 30 putative TaLACS genes. It was found that 22 genes were expressed in wheat anthers, and a gene regulatory network related to male fertility was discovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tiangang Wu, Mengling Wang, Fengling Ning, Shilin Zhou, Xuetao Hu, Hong Xin, Svetlana Reilly, Xuemei Zhang
Summary: Fibrosis, characterized by excessive production of extracellular matrix, is a common pathological feature of organ diseases. Metabolic alterations, especially in the regulation of branched-chain amino acids (BCAAs), have been found to play significant roles in fibrogenesis. Dysregulation of BCAAs metabolism has been implicated in various diseases. This review summarizes the metabolic regulation of fibrosis, changes in BCAAs metabolism associated with fibrosis, and the effects and mechanisms of BCAAs intervention in hepatic, renal, and cardiac fibrosis, with a focus on liver fibrosis and associated hepatocellular carcinoma.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Virology
Laura A. St Clair, Stephanie A. Mills, Elena Lian, Paul S. Soma, Aritra Nag, Caroline Montgomery, Gabriela Ramirez, Nunya Chotiwan, Rebekah C. Gullberg, Rushika Perera
Summary: During infection with dengue viruses, the lipid landscape within host cells is altered to support viral replication and particle assembly. Fatty acyl-CoAs, which are key intermediates in lipid biosynthesis, play a role in this process. Loss of function of certain enzymes involved in fatty acyl-CoA metabolism leads to increased viral replication and infectious particle release, while loss of others results in decreased protein translation, genome replication, and virus release. The specific location of these enzymes within the cell may contribute to the differences observed in dengue virus infection. Loss of mitochondrial ACOT2 and ACOT7 expression also affects the expression of other ACOTs located in different organelles within the cell, suggesting a complex relationship between ACOTs in the virus lifecycle.
Article
Endocrinology & Metabolism
Ninghua Li, Jing Li, Hui Wang, Jinnan Liu, Weiqin Li, Kai Yang, Xiaoxu Huo, Junhong Leng, Zhijie Yu, Gang Hu, Zhongze Fang, Xilin Yang
Summary: BCAAs in early pregnancy are positively associated with the risk of GDM, and high levels of leucine and isoleucine enhance the risk association of high SFA16:0 with GDM, independent of LPCs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Emily Kwun Kwan Lo, Felicianna, Jing-Hang Xu, Qiao Zhan, Zheng Zeng, Hani El-Nezami
Summary: Branched-chain amino acids (BCAAs) are related to chronic liver diseases, but BCAA supplementation has positive effects on cirrhosis and hepatocellular carcinoma (HCC) patients. This review aims to clarify the contradictory claims and study the role of BCAAs in liver health.
Article
Nutrition & Dietetics
Iris Trefflich, Stefan Dietrich, Annett Braune, Klaus Abraham, Cornelia Weikert
Summary: This study compared concentrations of SCFA, BCFA, ammonia, and fecal pH between vegans and omnivores, finding no significant differences in SCFA and BCFA concentrations but lower fecal pH and ammonia concentration in vegans. The results suggest that bacterial functionality may be adapted to varying nutrient availability in these diets.
Article
Materials Science, Multidisciplinary
Qiu-Ren Pan, Si-Jie Li, Kaixin Tong, Chong Xie, Lijuan Peng, Nan Li, Dong-Yao Wang, Hong Su
JOURNAL OF MATERIALS SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Peng-Yang Jiang, Zhi-Hui Xiao, Yi-Fan Wang, Nan Li, Zhao-Qing Liu
Summary: The Ag/Co-N-C bifunctional catalyst was designed and synthesized for MFCs, with the optimized Ag/Co-N-C-30 exhibiting excellent ORR performance and antimicrobial ability, leading to enhanced power generation capacity and long-term stability of the MFCs.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Physical
Peng-Yang Jiang, Zhi-Hui Xiao, Shu-Hua Li, Zi-Nuo Luo, Rui Qiu, Huixiang Wu, Nan Li, Zhao-Qing Liu
Summary: The study developed Fe-N-S/C as bifunctional electrode materials, which showed outstanding biocompatibility and electrocatalytic activity, leading to improved performance of MFCs and facilitation of their practical application.
JOURNAL OF POWER SOURCES
(2021)
Article
Environmental Sciences
Qiu-Ren Pan, Peng-Yang Jiang, Bi-Lin Lai, Yun-Bing Qian, Li-Juan Huang, Xiao-Xin Liu, Nan Li, Zhao-Qing Liu
Summary: The study investigates the exploration of low-cost, long-term stable, and highly electrochemically active cathode catalysts for microbial fuel cells (MFC). A series of 3D hierarchical porous Co-N-C materials are synthesized and designed, showing excellent performance in terms of oxygen reduction reaction (ORR) and durability. The study also reveals the influence of different ORR activity cathode catalysts on the types and abundance of anode microorganisms.
Article
Electrochemistry
Bi-Lin Lai, Zhi-Hui Xiao, Peng-Yang Jiang, Yong Xie, Nan Li, Zhao-Qing Liu
Summary: Ag-Fe-N/C catalysts with good electrocatalytic activity have been developed for microbial fuel cells (MFC). The catalyst not only improves the efficiency and stability of MFC, but also affects the microbial community structure on the cathode biofilm.
Article
Chemistry, Physical
Yong Xie, Si-Jie Li, Jie-Ping Huang, Rui Qiu, Zhao-Qing Liu, Nan Li
Summary: This study synthesized a Cu-Co9S8-NHCS-1 electrocatalyst by cleverly doping copper into Co9S8 and combining it with nitrogen-doped hollow carbon spheres. The electrocatalyst exhibited remarkable activity and durability for oxygen reduction reactions (ORR) and oxygen evolution reactions (OER). Zinc-air batteries and microbial fuel cells with the Cu-Co9S8-NHCS-1 cathode showed high power density and long-term stability.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Nanoscience & Nanotechnology
Qiu-Ren Pan, Bi-Lin Lai, Li-Juan Huang, Yan-Nan Feng, Nan Li, Zhao-Qing Liu
Summary: In this study, a three-dimensional hierarchical porous copper, nitrogen, and boron codoped carbon catalyst was synthesized, which exhibited excellent oxygen reduction reaction (ORR) performance and stability. The introduction of boron atoms increased the electron density around the active site, promoting the efficiency of the ORR process and preventing demetallization. This research provides a new approach for the development of Cu-based ORR electrocatalysts and guidance for high-performance microbial fuel cells (MFCs) design.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Environmental Sciences
Bi-Lin Lai, Hui-Xu Wei, Zi-Nuo Luo, Tong Zheng, Yi-Hui Lin, Zhao-Qing Liu, Nan Li
Summary: Cu-N/C@Cu composites were synthesized as bifunctional cathode catalysts for microbial fuel cells (MFC) by doping, adsorption, and two calcinations using Cu-ZIF-8 as the precursor. The optimized Cu-N/C@Cu-2 catalyst with higher Cu-Nx content exhibited excellent ORR catalytic activity. The MFCs assembled with Cu-N/C@Cu-2 achieved a maximum power density of 581 +/- 13 mW m-2, even better than that using Pt/C (499 +/- 13 mW m-2). The higher Cu content in Cu-N/C@Cu-2 also effectively prevented cathode biofilm contamination.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Bi-Lin Lai, Hai-Xia Liao, Shu-Qi Zhou, Hui-Xu Wei, Ai-Yi Li, Nan Li, Zhao-Qing Liu
Summary: This study successfully prepared a series of chalcogen-modified copper and nitrogen co-doped catalysts, which showed improved oxygen reduction reaction (ORR) performance through proper chalcogen doping while maintaining antibacterial properties. Among these catalysts, the optimized Cu2S@Cu-SNC-2 catalyst exhibited excellent durability and ORR activity, outperforming the commercial Pt/C catalyst. The MFC based on Cu2S@Cu-SNC-2 also achieved significantly higher power density and had fewer cathode biofilms.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Applied
Si-Jie Li, Yong Xie, Bi-Lin Lai, Yingmin Liang, Kang Xiao, Ting Ouyang, Nan Li, Zhao-Qing Liu
Summary: In this study, cobalt pentlandite with ionic modulation and nitrogen-doped bowl-like hollow carbon spheres were designed and synthesized, showing excellent electrocatalytic performance in oxygen reduction reaction and oxygen evolution reaction. By using this material as the cathode of a rechargeable Zn-air battery and the anode of a microbial fuel cell, high energy efficiency and power density can be achieved.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Li-Juan Peng, Jie-Ping Huang, Qiu-Ren Pan, Ying Liang, Na Yin, Hang-Chang Xu, Nan Li
Summary: A low-cost, simple, and efficient method has been developed to prepare excellent bifunctional electrocatalysts for ORR and OER, which is beneficial for the practical large-scale application of zinc-air batteries. The resulting mixture of Ni0.85Se and Co0.85Se on NHCS shows better ORR and OER dual catalytic functions than a single selenide, leading to improved charge and discharge performance and stability over precious metals in zinc-air batteries.
Article
Chemistry, Multidisciplinary
Xiao-Tong Wu, Li-Juan Peng, Kang Xiao, Nan Li, Zhao-Qing Liu
Summary: In this study, a hollow Fe-N/C catalyst was synthesized via a hard-templating strategy with well-dispersed FeNx sites on carbon spheres. Optimizing the iron ratio on the catalyst surface enhanced the alkaline ORR activity. With a high specific surface area of 311.71 m(2) g(-1), the catalyst exhibited superior ORR activity in alkaline solution due to abundant electroactive sites facilitating the adsorption of oxygen intermediates.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Kang Xiao, Shen-Long Zhao, Meizhi Cao, Liang Zhang, Nan Li, Zhao-Qing Liu
JOURNAL OF MATERIALS CHEMISTRY A
(2020)
Article
Chemistry, Physical
Xiao-Peng Li, Wen-Kai Han, Kang Xiao, Ting Ouyang, Nan Li, Feng Peng, Zhao-Qing Liu
CATALYSIS SCIENCE & TECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Kang Xiao, Tai-Quan Xiao, Yirong Zhang, Jingxin Xie, Meizhi Cao, Nan Li, Ting Ouyang, Zhao-Qing Liu
CHEMICAL COMMUNICATIONS
(2019)
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)
