Article
Chemistry, Inorganic & Nuclear
Brandon L. Munnik, Catherine H. Kaschula, Daniel J. Watson, Lubbe Wiesner, Leigh Loots, Prinessa Chellan
Summary: In this study, six half-sandwich complexes of iridium (III), rhodium (III), and ruthenium (II) bearing the N,N'-chelated ligand 2-(2-pyridyl)benzimidazole were synthesized and characterized. These complexes were tested for their catalytic and antimalarial activities, with the iodido complexes showing favorable results in both assays.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Lydia Jordaan, Malcolm T. Ndlovu, Sinethemba Mkhize, Siyabonga Ngubane, Leigh Loots, Sandra Duffy, Vicky M. Avery, Prinessa Chellan
Summary: Six cationic half-sandwich Ir(III) and Rh(III) complexes were synthesized and fully characterized. The crystal structures of these complexes were determined by X-ray diffraction. The complexes displayed moderate to good activity against Plasmodium falciparum and were not cytotoxic to human cells.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ramesh Katla, Rakhi Katla
Summary: A microwave-assisted C-S and C-Se cross-coupling reaction was conducted using low-cost CuI catalyst in acetonitrile. The reaction successfully achieved high yields of the desired products, and a series of novel compounds were synthesized.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Kirk Wilson, Kerrie-Ann Wilson, Crystal Thompson, Mark A. W. Lawrence
Summary: The ability of six pincer type molecules to detect MBr2 in DMSO was quantified via formation constants determined from spectrophotometric and voltammetric titrations. The limit of detection of the molecules ranged from 0.9-9.5 ppm. The results indicated that certain molecules had good affinity for specific metal ions.
Article
Biochemistry & Molecular Biology
Benson M. Kariuki, Bakr F. Abdel-Wahab, Hanan A. Mohamed, Mohamed S. Bekheit, Gamal A. El-Hiti
Summary: This study reported the synthesis of chalcones by reacting 1-(5-methyl)-1H-1,2,3-triazol-4-yl)ethan-1-ones with benzaldehydes under basic conditions in ethanol. Furthermore, it was found that the synthesized chalcones could react with thiosemicarbazide, followed by reaction with specific ketones, to yield pyrazolyl-thiazole compounds with novel structures. The structures of six newly synthesized heterocycles were confirmed by X-ray crystallography.
Article
Chemistry, Physical
Goknil Pelin Coskun, Zafer Sahin, Omer Erdogan, Ozge Cevik, Sevde Nur Biltekin, Leyla Yurttas, Barkin Berk, Mert Ulgen, Seref Demirayak
Summary: In this study, novel 4-(2/3/4-pyridyl)thiazole-2-acetamide derivatives were discovered and their structures were elucidated. The synthesized compounds showed excellent activity against chondrosarcoma cells and no cytotoxicity against healthy fibroblast cells. The anti-cancer activity of the compounds may depend on tyrosine kinase inhibition and their ability to induce apoptosis in chondrosarcoma cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Yasir Iqbal, Muhammad Haroon, Tashfeen Akhtar, Muhammad Ashfaq, Muhammad Nawaz Tahir, Lubna Rasheed, Muhammad Yousuf, Muhammad Abid Zia
Summary: In this study, two novel adamantyl based thiazoles were synthesized via a simple cyclization reaction and their structures and properties were investigated using spectro-analytical techniques and Density Functional Theory. The results showed that one of the compounds is a strong electrophile while the other is a moderate electrophile.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Romain Mustiere, Prisca Lagardere, Sebastien Hutter, Viviana Dell'Orco, Nadia Amanzougaghene, Shahin Tajeri, Jean-Francois Franetich, Sophie Corvaisier, Marc Since, Aurelie Malzert-Freon, Nicolas Masurier, Vincent Lisowski, Pierre Verhaeghe, Dominique Mazier, Nadine Azas, Patrice Vanelle, Nicolas Primas
Summary: Gamhepathiopine (M1) is a multi-stage acting antiplasmodial compound with poor stability, insufficient solubility, and low permeability. In this study, we synthesized 20 new derivatives based on a scaffold hopping strategy from M1, and identified a promising candidate, furane bioisostere 3j, with improved solubility and intestinal permeability, as well as good antiplasmodial activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Hossain, Carlos E. Enci, Jonathan R. Dimmock, Umashankar Das
Summary: This review outlines the discovery and development of a novel series of compounds as potential drug candidates over the last 15 years, showing excellent cytotoxicity, tumor-selective toxicity, and modulatory effects on multi-drug resistance. These molecules exhibit promising antitumor and antimicrobial properties, with good tolerability in short-term toxicity studies in mice.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Yasir Iqbal, Tashfeen Akhtar, Muhammad Haroon, Hasnain Mehmood, Tauqir Nizami, Ehsaan Tahir, Muhammad Ehsan
Summary: Aim of this study was to develop an efficient and cost-effective antidiabetic agent. A series of compounds called 4-adamantyl-(2-(arylidene)hydrazinyl)thiazoles were synthesized using a simple Hantzsch synthetic strategy. The tested compounds showed excellent α-amylase inhibition, comparable antiglycation potential, and excellent antioxidant potential. Compound 3a was identified as a potent α-amylase inhibitor.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Debakanta Tripathy, Amlan K. Pal, Soumya Lipsa Rath, Garry S. Hanan, Binod B. Panda, Dillip K. Chand
Summary: The title compound consists of a terpyridyl derivative bonded to a Pd(II) unit through a Pd-N coordinate bond. The crystal structure shows that the fourth coordination site of palladium is occupied by a nitrate ion. The complex has the ability to bind to B-DNA with an attractive van der Waals energy of -7.48 kcal/mol.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Dinesh Parshuram Satpute, Urjita Shirwadkar, Anil Kumar Tharalla, Sangita Dattatray Shinde, Gargi Nikhil Vaidya, Swarali Joshi, Priyanka Patel Vatsa, Alok Jain, Abhishek A. Singh, Rachana Garg, Amit Mandoli, Dinesh Kumar
Summary: Oral squamous cell carcinoma (OSCC) is the most common malignant epithelial neoplasm, affecting the mouth and throat, and accounting for 90% of oral cancers. The identification of a fluorinated 2-styryl 4(3H)-quinazolinone as a potential oral cancer drug candidate is reported. Initial studies show that the compound blocks the transition from G1 to S phase, leading to arrest in the G1/S phase. Subsequent RNA-seq analysis reveals that the compound activates apoptotic pathways and cell differentiation while suppressing pathways involved in cellular growth and development in CAL-27 cancer cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Qin Wang, Jun-Zhuo Guo, Cheng Zhang, Wen-Qi Sun, Rui-Lian Lin, Ming-Fu Ye, Jing-Xin Liu
Summary: In this study, the formation of inclusion complexes between cyclodextrins and pyridinium chloride was demonstrated, showing photochromic properties suitable for erasable inkless printing and anticounterfeiting. The color of printing on filter paper can be tuned by controlling the mass proportions of different inclusion complexes.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Abhijit Shinde, Prashant P. Thakare, Yogesh Nandurkar, Abhijit Chavan, Abdul Latif N. Shaikh, Pravin C. Mhaske
Summary: Resistance to antibiotic drugs has led to a life-threatening situation with mycobacterial infections, and in search of a new antimycobacterial compound, a series of derivatives were synthesized. Thirteen of these compounds showed moderate to good antitubercular activity, and were found to be non-cytotoxic to mouse fibroblast cells.
Article
Chemistry, Organic
Alexander S. Bunev, Dmitry A. Khochenkov, Yulia A. Khochenkova, Yulia S. Machkova, Elena V. Varakina, Rovshan E. Gasanov, Marina A. Troshina, Olga S. Avdyakova
Summary: A series of thiazolyl-substituted 4-aminopyrimidine compounds were successfully synthesized through a two-stage process, showing good anticancer effects in antiproliferative assays on three tumor lines A431, A549, and HT-1080.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Critical Care Medicine
Erick W. Bunyasi, Keren Middelkoop, Anastasia Koch, Zeenat Hoosen, Humphrey Mulenga, Angelique K. K. Luabeya, Justin Shenje, Simon C. Mendelsohn, Michele Tameris, Thomas J. Scriba, Digby F. Warner, Robin Wood, Jason R. Andrews, Mark Hatherill
Summary: This study found that airborne MTB genomic DNA was frequently detected in high school classrooms in South Africa, and the risk of classroom exposure was similar to that in public health clinics.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Kathrin Zuercher, Julien Riou, Carl Morrow, Marie Ballif, Anastasia Koch, Simon Bertschinger, Digby F. Warner, Keren Middelkoop, Robin Wood, Matthias Egger, Lukas Fenner
Summary: By modeling data from a primary care clinic in South Africa, this study identified young adults and relative humidity as potentially important factors for tuberculosis transmission. The findings highlight the need for estimating transmission and evaluating interventions.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Chemistry, Medicinal
Melissa D. Chengalroyen, Mandy K. Mason, Alessandro Borsellini, Raffaella Tassoni, Garth L. Abrahams, Sasha Lynch, Yong-Mo Ahn, Jon Ambler, Katherine Young, Brendan M. Crowley, David B. Olsen, Digby F. Warner, Clifton E. Barry, Helena I. M. Boshoff, Meindert H. Lamers, Valerie Mizrahi
Summary: Natural product nargenicin exhibits antimycobacterial activity against Mycobacterium tuberculosis by binding to replicative DNA polymerase DnaE1, inducing a DNA damage response and inhibiting bacterial growth. This finding provides a potential target for drug discovery efforts against tuberculosis.
ACS INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Ryan Dinkele, Sophia Gessner, Andrea McKerry, Bryan Leonard, Juane Leukes, Ronnett Seldon, Digby F. Warner, Robin Wood
Summary: This study compared the aerosolization of Mtb and total particulate matter from patients with TB during three respiratory maneuvers and found that tidal breathing may be the main contributor to the aerosolization of Mtb among TB patients on a daily basis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Microbiology
Gregory S. Basarab, Sandeep Ghorpade, Liezl Gibhard, Rudolf Mueller, Mathew Njoroge, Nashied Peton, Preshendren Govender, Lisa M. Massoudi, Gregory Thomas Robertson, Anne J. Lenaerts, Helena Ingrid Boshoff, Douglas Joerss, Tanya Parish, Thomas F. Durand-Reville, Manos Perros, Vinayak Singh, Kelly Chibale
Summary: This article describes a series of spiropyrimidinetrione (SPT) compounds with activity against Mycobacterium tuberculosis by inhibiting DNA gyrase. The SPT class of compounds operates through a novel mode of inhibition, which is not cross-resistant with other DNA gyrase-inhibiting antibacterials. Compound 22 from the series demonstrated in vitro cidality and intracellular activity against M. tuberculosis. The DNA gyrase mode of action was supported by inhibition of the target in a DNA supercoiling assay and elicitation of an SOS response in M. tuberculosis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Correction
Microbiology
Terry Kipkorir, Gabriel T. Mashabela, Timothy J. de Wet, Anastasia Koch, Stephanie S. Dawes, Lubbe Wiesner, Valerie Mizrahi, Digby F. Warner
JOURNAL OF BACTERIOLOGY
(2022)
Article
Plant Sciences
Celestine Raidron, Audrey Jordaan, Ronnett Seldon, Digby F. Warner, Carmen de Kock, Dale Taylor, Stefan Louw, Suthananda Sunassee, Renate Hazel Hans
Summary: This study evaluated the antiplasmodial and antimycobacterial activities of eight indigenous medicinal plants. The results indicated that certain organic extracts showed significant antiplasmodial and antimycobacterial activity, with potential unidentified lead compounds present. Further research is needed to fully characterize these active compounds for potential medical applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Omobolanle Janet Jesumoroti, Richard M. Beteck, Audrey Jordaan, Digby F. Warner, Lesetja J. Legoabe
Summary: Tuberculosis (TB) is a major cause of death worldwide. In this study, a library of 7H-Pyrrolo[2,3-d]pyrimidine derivatives was synthesized to develop new anti-TB compounds. Sixteen compounds showed activity against Mycobacterium tuberculosis, with the most potent derivative having a MIC90 value of 0.488 μM and no cytotoxicity. These findings suggest that these compounds have potential for further drug development and optimization.
MOLECULAR DIVERSITY
(2023)
Article
Multidisciplinary Sciences
Dapeng Chen, Noella A. Bryden, Wayne A. Bryden, Michael McLoughlin, Dexter Smith, Alese P. Devin, Emily R. Caton, Caroline R. Haddaway, Michele Tameris, Thomas J. Scriba, Mark Hatherill, Sophia Gessner, Digby F. Warner, Robin Wood
Summary: Human breath contains trace amounts of non-volatile organic compounds (NOCs) which could be used as markers of individual health. In this study, metabolites and lipids in exhaled breath aerosol (EBA) samples were analyzed to identify molecular signatures of active tuberculosis (TB). Thirteen metabolite and nine lipid markers were identified with statistically different values between individuals with active TB and healthy controls. Importantly, EBA lipid profiles can effectively distinguish the two sample types, indicating the diagnostic potential of the identified molecules.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
David A. Barr, Charlotte Schutz, Avuyonke Balfour, Muki Shey, Mireille Kamariza, Carolyn R. Bertozzi, Timothy J. de Wet, Ryan Dinkele, Amy Ward, Kathryn A. Haigh, Jean-Paul Kanyik, Valerie Mizrahi, Mark P. Nicol, Robert J. Wilkinson, David G. Lalloo, Digby F. Warner, Graeme Meintjes, Gerry Davies
Summary: This study developed methods to measure the bacillary load of Mycobacterium tuberculosis bloodstream infection (MTBBSI) in HIV-positive patients and investigated its response to anti-TB therapy and its relationship with mortality. The findings suggest that the developed methods can be used to evaluate the efficacy of treatment and may facilitate interventional trials in severe HIV-associated tuberculosis.
Article
Chemistry, Medicinal
Rashmika Moodley, Chakes Mashaba, Goitsemodimo H. Rakodi, Nomagugu B. Ncube, Mabuatsela Maphoru, Mohammed O. Balogun, Audrey Jordan, Digby F. Warner, Rene Khan, Matshawandile Tukulula
Summary: A series of new benzothiazole-urea-quinoline hybrid compounds were successfully synthesized and evaluated for their anti-tuberculosis activity. Some of the compounds showed promising activity and low cytotoxicity. The results indicate that these compounds could serve as valuable starting points for the development of new anti-Mycobacterium tuberculosis agents.
Article
Public, Environmental & Occupational Health
Keren Middelkoop, Anastasia S. Koch, Zeenat Hoosen, Wayne Bryden, Charles Call, Ronnett Seldon, Digby F. Warner, Robin Wood, Jason R. Andrews
Summary: This proof-of-concept study demonstrates the potential of using environmental air sampling to detect and quantify Mycobacterium tuberculosis, enabling the identification of high-risk transmission locations.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Chemistry, Medicinal
Ogunyemi. O. O. Oderinlo, Audrey Jordaan, Ronnett Seldon, Michelle Isaacs, Heinrich. C. C. Hoppe, Digby. F. F. Warner, Matshawandile Tukulula, Setshaba. D. D. Khanye
Summary: An exploratory series of new triazole derivatives were synthesized by combining arylpyrrole and triazole units via a hydrazone linkage. Compound 13 showed reasonable activity against Mycobacterium tuberculosis, but other compounds in the series displayed weak antimycobacterial activity.
Review
Biochemistry & Molecular Biology
Kristy R. Winkler, Valerie Mizrahi, Digby F. Warner, Timothy J. De Wet
Summary: Advances in sequencing technologies have provided new insights into bacterial genome composition and dynamics, but the slow validation of inferred genetic function presents a challenge. This is particularly relevant for Mycobacterium tuberculosis, which still has many genes of unknown function despite being one of the first genomes to be sequenced. We summarize the evolution of high-throughput functional genomics and discuss the potential of CRISPR interference in studying bacterial gene function.
MOLECULAR MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Phelelisiwe S. Dube, Klaudia T. Angula, Lesetja J. Legoabe, Audrey Jordaan, Jan M. Boitz Zarella, Digby F. Warner, J. Stone Doggett, Richard M. Beteck
Summary: In this study, 39 novel quinolone compounds with a hydrophilic amine chain and varied substituted benzyloxy units were described. These compounds demonstrated broad-spectrum activities against acid-fast bacterium, Gram-positive and-negative bacteria, fungi, and leishmania parasite. Compound 30 showed antitubercular activity against drug-resistant Mycobacterium tuberculosis, while compound 37 exhibited low micromolar activities against critical pathogens.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
