Review
Environmental Sciences
Katrina Marie Sta Ana, Jonalyn Madriaga, Maria Pythias Espino
Summary: This article summarizes the research on beta-lactam antibiotics and beta-lactam antibiotic resistant bacteria and genes in Asian lake and river waters. It discusses methods for analyzing these antibiotics in water and the need for comprehensive investigations regarding their impact on aquatic biota. Studies have shown the presence of beta-lactam antibiotics in ng/L concentrations in Asian aquatic environments, but more research is needed in this area.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Medicinal
Hamna Batool Hashmi, Muhammad Asad Farooq, Muhammad Hashim Khan, Abdulrahman Alshammari, Alanoud T. Aljasham, Sheikh Abdur Rashid, Nauman Rahim Khan, Irum Batool Hashmi, Muhammad Badar, Mohammad S. Mubarak
Summary: This study evaluated the efficacy of three fi-lactam drugs (meropenem, piperacillin, and tazobactam) alone and in combination against MRSA biofilms. The results showed that the combination of piperacillin and tazobactam exhibited the best removal effect on pre-formed MRSA biofilms.
Review
Chemistry, Inorganic & Nuclear
Micha Zabiszak, Justyna Frymark, Kazuma Ogawa, Monika Skrobanska, Martyna Nowak, Renata Jastrzab, Malgorzata T. Kaczmarek
Summary: Beta-lactam antibiotics are widely used in medicine due to their strong antibacterial activity. They are produced by fungi and bacteria, and their advantages lie in their potent bactericidal activity and wide spectrum of activity. The common mode of action of beta-lactam antibiotics involves inhibiting the synthesis of the bacterial cell wall, leading to the demise of the bacterial cell.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Microbiology
Xiaoya Wei, Jiacong Gao, Congjuan Xu, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Iain L. Lamont, Daniel Pletzer, Weihui Wu
Summary: This study reveals the response mechanism of P. aeruginosa to murepavadin and provides a promising antibiotic combination for the treatment of P. aeruginosa infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Xiaoya Wei, Jiacong Gao, Congjuan Xu, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Iain L. Lamont, Daniel Pletzer, Weihui Wu
Summary: This study reveals the response mechanism of Pseudomonas aeruginosa to murepavadin and provides a promising antibiotic combination for the treatment of P. aeruginosa infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Laurent Gavara, Alice Legru, Federica Verdirosa, Laurent Sevaille, Lionel Nauton, Giuseppina Corsica, Paola Sandra Mercuri, Filomena Sannio, Georges Feller, Remi Coulon, Filomena De Luca, Giulia Cerboni, Silvia Tanfoni, Giulia Chelini, Moreno Galleni, Jean-Denis Docquier, Jean-Francois Hernandez
Summary: Researchers are developing compounds based on the 1,2,4-triazole-3-thione scaffold to target resistance mechanisms in Gram-negative bacteria, with promising potential for broad-spectrum inhibitors. These compounds, particularly those containing a carboxylic group at the 4-position, have shown potent inhibition against VIM-type enzymes. Further exploration is needed to improve outer membrane penetration and efficacy against other carbapenemases.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Victor Band, David S. Weiss
Summary: Antibiotic resistance is a growing crisis in modern healthcare, traditionally thought to be caused by acquisition of genes or mutations, but heteroresistance may actually develop before resistance and often be a stage in its progression.
Article
Biochemistry & Molecular Biology
Le Zhai, Ya Liu, Yue Jiang, Jian Xiao, Yi-Xue Wang, Yang Shi, Yi-Lin Zhang, Ke-Wu Yang
Summary: In this study, a novel vancomycin derivative V-b was constructed and shown to have significant antimicrobial effects against drug-resistant strains, enhancing the antibacterial activity of β-lactam antibiotics. Furthermore, V-b was able to enhance the antimicrobial activity of meropenem against clinical isolates and E. coli producing ImiS and CcrA.
Article
Biotechnology & Applied Microbiology
Miguel Ribeiro, Sara Ceballos, Patricia Poeta, Carmen Torres, Gilberto Igrejas
Summary: A study using a proteomics approach revealed significant changes in protein expression in response to cefoxitin stress in MRSA, highlighting alterations in cellular metabolism, glycolysis, quorum sensing, and other functional pathways. These findings provide important insights for the treatment and research of MRSA and antibiotic resistance.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2021)
Article
Microbiology
Aaron C. Nolan, Merve S. Zeden, Igor Kviatkovski, Christopher Campbell, Lucy Urwin, Rebecca M. Corrigan, Angelika Gruendling, James P. O'Gara
Summary: The purine nucleosides guanosine and xanthosine have been found to resensitize methicillin-resistant Staphylococcus aureus (MRSA) to beta-lactam antibiotics by significantly reducing the levels of c-di-AMP, a cyclic dinucleotide required for beta-lactam resistance. These findings suggest the therapeutic potential of using purine nucleosides as adjuvants to enhance the effectiveness of beta-lactams against MRSA and other antimicrobial resistant (AMR) pathogens.
Article
Plant Sciences
Xiaoxia Li, Ping Wu, Hanxiang Li, Jinghua Xue, Hanhong Xu, Xiaoyi Wei
Summary: Formicapyridine-type racemates, streptovertidines, and fasamycin-type compounds were isolated from Streptomyces morookaense SC1169. Some of these compounds exhibited activity against drug-resistant bacteria and human carcinoma cells, demonstrating higher selectivity for bacteria over mammalian cells. Structure-activity relationship analysis suggested chlorination at C-2 improves activity and selectivity. Theoretical simulations supported nonenzymatic pyridine ring formation via dicarbonyl condensation with ammonia.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Immunology
Grace Thompson, Andrew McLean-Tooke, Michaela Lucas
Summary: Current understanding of cross-reactivity in severe cutaneous adverse reactions to beta-lactam antibiotics is limited, and the underlying immunopathogenesis of these reactions is not completely understood. Research has shown that cross-reactivity or co-reactivity commonly occurred among the beta-lactam antibiotic class, but further investigation is needed to understand and investigate patterns of cross-reactivity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Annett Mikolasch, Veronika Hahn
Summary: Trametes spec. laccase mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures to form new heteromolecular hybrid products, which inhibit the growth of Staphylococcus species, including multidrug-resistant strains.
Article
Biochemistry & Molecular Biology
Vidhu Agarwal, Tara Chand Yadav, Akhilesh Tiwari, Pritish Varadwaj
Summary: Antimicrobial resistance is a growing global health challenge. Bacterial infections have developed resistance against beta-lactam antibiotics through various mechanisms, including the production of novel beta-lactamase enzymes. These bacteria have also developed resistance against beta-lactamase inhibitors. Investigating the role of important residues in altering and expanding the spectrum activity of these enzymes is necessary to understand beta-lactamase-mediated resistance.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Infectious Diseases
Sarah C. J. Jorgensen, Jackson J. Stewart, Bruce R. Dalton
Summary: The article discusses the skepticism surrounding the use of precision dosing and therapeutic drug monitoring in the rapidly advancing field of antimicrobials, questioning whether it can truly improve patient outcomes. It advocates for critical appraisal and maintaining a skeptical attitude, while emphasizing the need for compelling evidence before adopting new technologies.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)