Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics

Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

(2021) Denny Chin et al.   Nature Communications

Mutations in a Membrane Permease or hpt Lead to 6-Thioguanine Resistance in Staphylococcus aureus

(2021) Denny Chin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA

(2021) Kristoffer T. Bæk et al.   Frontiers in Molecular Biosciences

Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics

(2021) Bartłomiej Salamaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Mechanistic Insights into Purine Biosynthesis with Second Messenger c-di-AMP in Relation to Biofilm-Related Persistent Methicillin-Resistant Staphylococcus aureus Infections

(2021) Liang Li et al.   mBio

Cyclic di-AMP Signaling in Bacteria

(2020) Jörg Stülke et al.   Annual Review of Microbiology

Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression

(2020) Viralkumar V. Panchal et al.   PLoS Pathogens

Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus

(2020) Tanit Boonsiri et al.   Scientific Reports

Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus

(2020) Stefano G. Giulieri et al.   mBio

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

(2019) Mariya I. Goncheva et al.   Nature Communications

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

(2019) Nicholas A. Turner et al.   NATURE REVIEWS MICROBIOLOGY

The purine biosynthesis regulator PurR moonlights as a virulence regulator in Staphylococcus aureus

(2019) William E. Sause et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis

(2019) Camilla Jensen et al.   PLoS Pathogens

The Sle1 Cell Wall Amidase Is Essential for β-Lactam Resistance in Community-Acquired Methicillin-Resistant Staphylococcus aureus USA300

(2019) Ida Thalsø-Madsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclic di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation inStaphylococcus aureusbut dispensable for viability in anaerobic conditions

(2018) Merve S. Zeden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus (MRSA) Infection

(2018) Liang Li et al.   JOURNAL OF INFECTIOUS DISEASES

Extracellular nucleotides and nucleosides as signalling molecules

(2018) Anna Lisa Giuliani et al.   IMMUNOLOGY LETTERS

c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulence of Gram-Positive Bacteria

(2017) Tazin Fahmi et al.   Genes

Role of the Stringent Stress Response in the Antibiotic Resistance Phenotype of Methicillin-Resistant Staphylococcus aureus

(2016) Sandra Aedo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance inStaphylococcus aureus

(2016) Lisa Bowman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Global RegulonsarARegulates β-Lactam Antibiotic Resistance in Methicillin-ResistantStaphylococcus aureusIn Vitro and in Endovascular Infections

(2016) Liang Li et al.   JOURNAL OF INFECTIOUS DISEASES

Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-ResistantStaphylococcus aureusInfections

(2016) Elaine M. Waters et al.   JOURNAL OF INFECTIOUS DISEASES

Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field

(2016) Angelika Gründling et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC inStaphylococcus aureus

(2016) Christopher F. Schuster et al.   Science Signaling

The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC inStaphylococcus aureus

(2016) Christopher F. Schuster et al.   Science Signaling

Cross-talk between Two Nucleotide-signaling Pathways inStaphylococcus aureus

(2015) Rebecca M. Corrigan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus USA300 Is Increased by Inactivation of the ClpXP Protease

(2014) Kristoffer T. Bæk et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein

(2014) Adam J. Underwood et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Targeting of PBP1 by β-lactams Determines recA/SOS Response Activation in Heterogeneous MRSA Clinical Strains

(2014) Konrad B. Plata et al.   PLoS One

Novel Determinants of Antibiotic Resistance: Identification of Mutated Loci in Highly Methicillin-Resistant Subpopulations of Methicillin-Resistant Staphylococcus aureus

(2014) J. Dordel et al.   mBio

Mutation of RNA Polymerase β-Subunit Gene Promotes Heterogeneous-to-Homogeneous Conversion of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus

(2013) Yoshifumi Aiba et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Whole-Genome Sequencing Reveals a Link Between β-Lactam Resistance and Synthetases of the Alarmone (p)ppGpp in Staphylococcus aureus

(2013) Michael M. Mwangi et al.   Microbial Drug Resistance

Cyclic di-AMP: another second messenger enters the fray

(2013) Rebecca M. Corrigan et al.   NATURE REVIEWS MICROBIOLOGY

Mutation in the C-Di-AMP Cyclase dacA Affects Fitness and Resistance of Methicillin Resistant Staphylococcus aureus

(2013) Vanina Dengler et al.   PLoS One

The Mechanism of Heterogeneous Beta-Lactam Resistance in MRSA: Key Role of the Stringent Stress Response

(2013) Choonkeun Kim et al.   PLoS One

Combination approaches to combat multidrug-resistant bacteria

(2013) Roberta J. Worthington et al.   TRENDS IN BIOTECHNOLOGY

A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus Genes

(2013) P. D. Fey et al.   mBio

The RpoB H481Y Rifampicin Resistance Mutation and an Active Stringent Response Reduce Virulence and Increase Resistance to Innate Immune Responses in Staphylococcus aureus

(2012) Wei Gao et al.   JOURNAL OF INFECTIOUS DISEASES

Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections

(2012) Clarissa Pozzi et al.   PLoS Pathogens

Loss of Function of the GdpP Protein Leads to Joint β-Lactam/Glycopeptide Tolerance in Staphylococcus aureus

(2011) J. M. Griffiths et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code

(2010) A. Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of the (p)ppGpp Synthase RSH, a RelA/SpoT Homolog, in Stringent Response and Virulence of Staphylococcus aureus

(2010) T. Geiger et al.   INFECTION AND IMMUNITY

Golden Pigment Production and Virulence Gene Expression Are Affected by Metabolisms in Staphylococcus aureus

(2010) L. Lan et al.   JOURNAL OF BACTERIOLOGY

Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New  -Lactams That Meet the Challenge

(2009) L. I. Llarrull et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial nucleotide-based second messengers

(2009) Christina Pesavento et al.   CURRENT OPINION IN MICROBIOLOGY