Article
Veterinary Sciences
Shijing Sun, Hui Jiang, Qiaoling Li, Yufu Liu, Qiang Gao, Wei Liu, Yuming Qin, Yu Feng, Xiaowei Peng, Guanlong Xu, Qingchun Shen, Xuezheng Fan, Jiabo Ding, Liangquan Zhu
Summary: The study evaluated the safety of the S2 vaccine strain on primates using cynomolgus monkeys as animal models. Results indicated that the S2 vaccine was safe for cynomolgus monkeys, with transcriptome analysis revealing differentially expressed genes involved in various biological processes. This study provides a genetic basis for understanding host response following vaccination with the S2 vaccine.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Virology
Fengmei Yang, Yanyan Li, Yongjie Li, Weihua Jin, Suqin Duan, Hongjie Xu, Yuan Zhao, Zhanlong He, Yasushi Ami, Yuriko Suzaki, Yen Hai Doan, Naokazu Takeda, Wenjing Zhang, Masamichi Muramatsu, Tian-Cheng Li
Summary: Through experimental studies, it was found that cynomolgus and rhesus monkeys are susceptible to rat hepatitis E virus (rat HEV) and may cause zoonotic infections. These findings provide an animal model for the development of vaccines.
Article
Immunology
Hongzhong Yang, Wei Pan, Guoyu Chen, Enqi Huang, Qijiong Lu, Yunxiang Chen, Ying Chen, Zhengbiao Yang, Lei Wen, Siming Zhang, Cong Xu, Wanqiang Lv, Lianpan Dai, Changwei Wu, Lijiang Zhang
Summary: The COVID-19 pandemic caused by the new coronavirus continues to be a global public health problem. ZF2001, a protein vaccine based on SARS-CoV-2, has been found to be safe and immunogenic in cynomolgus monkeys, supporting its advancement into large scale clinical trials.
Article
Engineering, Biomedical
Cheung Kwan Yeung, Yaping Yan, Li Yan, Yanchao Duan, Enqin Li, Borong Huang, Ke Lu, Koukou Li, Muya Zhou, Lei Zhang, Yaojiong Wu, Kathy Qian Luo, Weizhi Ji, Ren-He Xu, Wei Si
Summary: Previous research has shown that locally-administered MSCsp can promote wound healing and alleviate multiple sclerosis and osteoarthritis, while intravenous injection of MSCsp in cynomolgus monkeys has been found to be feasible, safe, and potentially associated with better efficacy.
Article
Neurosciences
Yu Bao, Chaoning Gan, Zuyue Chen, Zhongquan Qi, Zhiqiang Meng, Feng Yue
Summary: This study evaluated non-motor symptoms in an MPTP-induced non-human primate PD model using a battery of behavioral tests. The MPTP-treated monkeys showed cognitive deficits, abnormal sleep, and anxiety-like behaviors, which were partially relieved by PPX treatment. These results suggest that the MPTP-induced PD monkeys displayed non-motor symptoms similar to those found in PD patients, and PPX treatment had moderate therapeutic effects on these symptoms. This battery of behavioral tests may serve as a valuable model for future preclinical research.
Article
Chemistry, Medicinal
Youzhi Wang, Huifang Wang, Guoqing Yang, Qingjing Hao, Kan Yang, Huizhen Shen, Yulong Wang, Jinxin Wang
Summary: It is well known that COPD patients suffer from chronic inflammation and oxidative stress. In this study, a novel class of PDE4 inhibitors with antioxidant properties were identified from natural products and synthesized to design bifunctional compounds. These compounds showed better PDE4 inhibitory activity than the original inhibitor and superior radical scavenging abilities. They also exhibited anti-inflammatory effects and stability in vivo.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Nidhi Sharda, Purnima Khandelwal, Lisa Zhang, Janet Caceres-Cortes, Punit Marathe, Anjaneya Chimalakonda
Summary: This study investigated the pharmacokinetics of PEG40 in non-clinical species and predicted its pharmacokinetic parameters in humans. The results showed that the intrinsic PK parameters of PEG40 in mice, rats and cynomolgus monkeys are consistent with published literature values, while showing differences in humans.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Maren S. Kops, Marija Pesic, Karl-Uwe Petersen, Wolfgang A. Schmalix, Thomas Stoehr
Summary: The study aimed to investigate the pharmacodynamic drug-drug interaction potential of Remimazolam with the opioid analgesic remifentanil, finding that Remimazolam has a high degree of sedative effect and shows significant synergism with remifentanil.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hiroko Izumi-Nakaseko, Kengo Sakamoto, Ai Goto, Ryuichi Kambayashi, Akio Matsumoto, Yoshinori Takei, Akira Takahara, Atsushi Sugiyama
Summary: We investigated the time course of pathological remodeling in cynomolgus monkey hearts with persistent atrioventricular block. The block led to ventricular and atrial dilation, followed by ventricular hypertrophy and interstitial fibrosis. Gene expression changes related to fibrosis and hypertrophy were observed. Cardiac output was initially reduced but gradually restored, while systolic/diastolic blood pressure remained the same or lower. QT interval prolongation and dl-sotalol-induced torsade de pointes (TdP) were observed in animals with longer QTcF. The small effective size of the monkey's heart contributed to the spontaneous termination of TdP. This knowledge can be valuable for using chronic atrioventricular block monkeys as an in vivo proarrhythmia model for detecting drug-induced TdP.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Maria Joao Bonifacio, Filipa Sousa, Patricio Soares-da-Silva
Summary: Opicapone, as an adjunctive therapy to levodopa, enhances the effects of levodopa/benserazide combinations in alleviating Parkinson's-like symptoms, leading to improved motor behavior in cynomolgus monkeys, which was later demonstrated in Phase 3 studies in Parkinson's disease patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Zhan-Hong Zheng, Qing Tian, Jia-Peng He, Jing-Li Yuan, Shi-Hua Yang, Ji-Long Liu
Summary: In this study, the researchers analyzed global gene expression changes associated with cryptorchidism in mice using RNA-seq. They identified differentially expressed genes involved in the activation of inflammatory response and identified causal transcription factors. Additionally, they conducted the same experiment in cynomolgus monkeys and performed a cross-species comparison at the gene expression level. This study provides a valuable resource for understanding the molecular mechanisms of cryptorchidism in mammals.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Immunology
Yingshuo Wang, Xinyan Dong, Caizhe Pan, Cihang Zhu, Hantao Qi, Yifan Wang, Hao Wei, Qiangmin Xie, Lei Wu, Huijuan Shen, Shuxian Li, Yicheng Xie
Summary: In this study, a monkey model of asthma was established and analyzed using single-cell RNA sequencing. The model exhibited airway hyperresponsiveness and remodeling, with an increase in the number of various cell types. These findings provide valuable insights into the understanding of asthma pathogenesis and potential treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Sri Rahmatul Laila, Dewi Apri Astuti, Irma Herawati Suparto, Ekowati Handharyani, Thomas C. Register, Dondin Sajuthi
Summary: This study assessed carotid artery lesions in Indonesian cynomolgus monkeys exposed to an atherogenic diet. The results showed severe atherosclerosis and macrophage infiltration in monkeys with intermediate and hyper-responsive characteristics.
VETERINARY SCIENCES
(2022)
Article
Cell Biology
Kui Duan, Chen-Yang Si, Shu-Mei Zhao, Zong-Yong Ai, Bao-Hua Niu, Yu Yin, Li-Feng Xiang, Hao Ding, Yun Zheng
Summary: The research found that MacERV6-LTR1a plays an important role in the early development of cynomolgus monkey embryos, and silencing it delays cell differentiation in the embryos. Furthermore, MacERV6-LTR1a can recruit ESRRB, a protein that plays a role in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells.
Article
Engineering, Biomedical
Jingliang Dong, Jiawei Ma, Lin Tian, Kiao Inthavong, Kazuhide Ito, Jiyuan Tu
Summary: This study numerically investigated the nanoparticle transport process through a realistic cynomolgus monkey nasal airway and found consistent deposition patterns along with specific spatial regions where particles tend to pass through. The research provides insight into nanoparticle inhalation exposure characteristics in the monkey airway and data extrapolation schemes between monkey and human airways.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)