Pharmacokinetics of 40 kDa Polyethylene glycol (PEG) in mice, rats, cynomolgus monkeys and predicted pharmacokinetics in humans

Predicting bioavailability of monoclonal antibodies after subcutaneous administration: Open innovation challenge

(2020) Manuel Sánchez-Félix et al.   ADVANCED DRUG DELIVERY REVIEWS

Pharmacokinetics, excretion, distribution, and metabolism of 60-kDa polyethylene glycol used in BAY 94-9027 in rats and its value for human prediction

(2019) Andreas Baumann et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetics of 40 kDa PEG in rodents using high-field NMR spectroscopy

(2019) Purnima Khandelwal et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

(2017) Deborah Charych et al.   PLoS One

Pharmacokinetic Time Course Scaling of a Subcutaneously Administered Pegylated Peptide Conjugate for a First-in-Human Investigation

(2016) Elliot Offman et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Pharmacokinetics, tissue distribution and excretion of 40kDa PEG and PEGylated rFVIII (N8-GP) in rats

(2016) Inga Bjørnsdottir et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

What is the future of PEGylated therapies?

(2015) Magdalena Swierczewska et al.   EXPERT OPINION ON EMERGING DRUGS

Anatomical, Physiological, and Experimental Factors Affecting the Bioavailability of sc-Administered Large Biotherapeutics

(2015) Anas M. Fathallah et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance after Subcutaneous Administration

(2015) Linda J. Chan et al.   MOLECULAR PHARMACEUTICS

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

(2014) Andreas Baumann et al.   DRUG DISCOVERY TODAY

PEG — A versatile conjugating ligand for drugs and drug delivery systems

(2014) Atul Kolate et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases

(2013) Lisa M. Kaminskas et al.   JOURNAL OF CONTROLLED RELEASE

Biodistribution and Excretion of Radiolabeled 40kDa Polyethylene Glycol Following Intravenous Administration in Mice

(2013) Clifford B. Longley et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

(2012) Wolfgang F. Richter et al.   AAPS Journal

Analytical Measurement of PEGylated Molecules

(2012) Tian-Lu Cheng et al.   BIOCONJUGATE CHEMISTRY

Prediction of Human Pharmacokinetics of Therapeutic Monoclonal Antibodies from Simple Allometry of Monkey Data

(2011) Masataka Oitate et al.   Drug Metabolism and Pharmacokinetics

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

(2011) Ragini Vuppugalla et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetics, tissue distribution, excretion, and antiviral activity of pegylated recombinant human consensus interferon-α variant in monkeys, rats and guinea pigs

(2011) Yongming Cai et al.   REGULATORY PEPTIDES

Sensitive Quantification of PEGylated Compounds by Second-Generation Anti-Poly(ethylene glycol) Monoclonal Antibodies

(2010) Yu-Cheng Su et al.   BIOCONJUGATE CHEMISTRY

Gas-Phase Proton-Transfer Chemistry Coupled with TOF Mass Spectrometry and Ion Mobility-MS for the Facile Analysis of Poly(ethylene glycols) and PEGylated Polypeptide Conjugates

(2008) Dhanashri Bagal et al.   ANALYTICAL CHEMISTRY

Pharmacokinetic properties of a 40 kDa branched polyethylene glycol-modified form of consensus interferon-α (PEG-CIFN) in rhesus monkeys

(2008) Yu Du et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Reversible pegylation of insulin facilitates its prolonged action in vivo

(2008) Y SHECHTER et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS