Article
Oncology
Tomonori Higuchi, Yumiko Hashida, Kazuhiko Matsuo, Kosuke Kitahata, Takako Ujihara, Ichiro Murakami, Takashi Nakayama, Masanori Daibata
Summary: Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) develops in the setting of long-standing inflammation. This type of lymphoma may have specific expression profiles of chemokines involved in the pathogenesis of DLBCL-CI. EBV-positive pyothorax-associated lymphoma (PAL) is a prototype of DLBCL-CI and represents a valuable model for the study of this disease category.
Article
Medicine, Research & Experimental
Jan-Hendrik Riedel, Lennart Robben, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Ning Song, Anett Peters, Anna Kaffke, Alina Borchers, Gisa Tiegs, Larissa Seifert, Nicola M. Tomas, Elion Hoxha, Ulrich O. Wenzel, Tobias B. Huber, Thorsten Wiech, Jan-Eric Turner, Christian F. Krebs, Ulf Panzer
Summary: Glucocorticoids, a cornerstone of therapy for autoimmune and chronic inflammatory diseases, exert their therapeutic effects by reducing the number of proinflammatory T cells in the kidney. This study found that high-dose steroid treatment decreases the recruitment of CXCR3(+)CD4(+) T cells to the inflamed kidneys by acting directly on renal tissue cells, leading to an amelioration of the disease course. The study identified the CXCL9/CXCL10-CXCR3 axis as a previously unrecognized cellular and molecular target of glucocorticoids.
Article
Oncology
Yihe Yan, Leting Zheng, Qiang Du, Hamza Yazdani, Kun Dong, Yarong Guo, David A. Geller
Summary: IRF-1 regulates anti-tumor immunity in HCC by modulating CXCL10 and CXCR3, inhibiting proliferation and promoting apoptosis. It overcomes proliferation partly through activating the CXCL10/CXCR3 autocrine axis.
Article
Immunology
Xuan Wang, Mara Lennard Richard, Tomika S. Caldwell, Kamala Sundararaj, Shuzo Sato, Tamara K. Nowling, Xian K. Zhang
Summary: The transcription factor Fli-1 is involved in the pathogenesis of lupus disease by regulating the expression of CXCL10 and CXCR3, which play important roles in renal inflammation and damage. Targeting Fli-1 or the CXCL10-CXCR3 axis may provide new approaches for lupus treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Giulia Baresi, Mauro Giacomelli, Daniele Moratto, Marco Chiarini, Immacolata Claudia Conforti, Rita Padoan, Piercarlo Poli, Silviana Timpano, Francesca Caldarale, Raffaele Badolato
Summary: The study compared inflammatory markers in CF patients with and without COVID-19, aiming to understand the changes in inflammation levels during the pandemic in individuals with cystic fibrosis.
FRONTIERS IN PEDIATRICS
(2021)
Editorial Material
Immunology
Robin Reschke, Thomas F. Gajewski
Summary: CXCL9 and CXCL10 are produced by antigen-presenting cells and tumor cells, and they co-localize with LAG3(+) T cells expressing CCL4 or CXCL13, contributing to the generation of a hot tumor microenvironment.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Robin Reschke, Thomas F. Gajewski
Summary: CXCL9 and CXCL10, produced by antigen-presenting cells and tumor cells, co-localize with LAG3(+) T cells expressing CCL4 or CXCL13, contributing to the generation of a hot tumor microenvironment.
SCIENCE IMMUNOLOGY
(2022)
Article
Oncology
Jack Y. Lee, Bianca Nguyen, Anandaroop Mukhopadhyay, Mia Han, Jun Zhang, Ravindra Gujar, Jon Salazar, Reneta Hermiz, Lauren Svenson, Erica Browning, H. Kim Lyerly, David A. Canton, Daniel Fisher, Adil Daud, Alain Algazi, Joseph Skitzki, Christopher G. Twitty
Summary: This study demonstrates that localized IL-12 and CXCL9 treatment can reshape the tumor microenvironment, promote immune cell activation, and induce anti-tumor responses. Additionally, this combination treatment shows synergy with anti-PD-1 therapies.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Cell Biology
Naureen Javeed, Tracy K. Her, Matthew R. Brown, Patrick Vanderboom, Kuntol Rakshit, Aoife M. Egan, Adrian Vella, Ian Lanza, Aleksey Matveyenko
Summary: The study demonstrates that pro-inflammatory beta cell-derived small EVs disrupt beta cell function, promote inflammatory responses, and enhance immune cell recruitment in the islets. Furthermore, CXCL10 chemokine enriched in these EVs binds to CXCR3 receptors on beta cells, modulating inflammatory gene expression and leukocyte recruitment.
Article
Allergy
Yu-Wen Hsu, Hsing-Fang Lu, Wan-Hsuan Chou, Ho-Chang Kuo, Wei-Chiao Chang
Summary: This study found a close correlation between genetic polymorphisms of IP10 and Kawasaki disease, particularly the influence of rs3921 and rs4386624 genotypes on the susceptibility to Kawasaki disease.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Microbiology
Farzaneh Hassanshahi, Mojgan Noroozi Karimabad, Elahe Miranzadeh, Gholamhossein Hassanshahi, Seyedeh Atekeh Torabizadeh, Ali Jebali
Summary: The study investigated the association between Brucella infection and the chemokines CXCL9, 10, and 11. The results showed that the serum levels of these chemokines were significantly increased in patients with acute brucellosis, suggesting their potential as markers for the disease.
CURRENT MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peiyu Liang, Xinyi Zhang, Yahui Zhang, Yifan Wu, Yinghao Song, Xueyang Wang, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Fanggang He, Yuanteng Fan, Song Han, Xiaohua He
Summary: Epilepsy is a common neurological disorder, and a new form of cell death called ferroptosis is associated with seizures. This study found that neuronal ferroptosis dependent on GPX4-GSH was detected in epileptic mice and could be attenuated by ferroptosis inhibitors. Additionally, neurotoxic A1 astrocytes activated in epilepsy facilitated seizure-related neuronal ferroptosis. Inhibiting ferroptosis blocked A1 astrocyte-induced neurotoxicity. A1 astrocyte-secreted CXCL10 enhanced STAT3 phosphorylation but suppressed SLC7A11 in neurons, leading to ferroptosis-associated lipid peroxidation in a GPX4-dependent manner. Clinical findings also showed a significant correlation between neuronal ferroptosis and A1 astrocytes in epileptic patients. In conclusion, this study reveals that A1 astrocyte-induced neuronal ferroptosis contributes to the pathogenesis of epilepsy, providing a novel therapeutic target for precision medicine.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yuki Sasaki, Hideki Arimochi, Kunihiro Otsuka, Hiroyuki Kondo, Shin-ichi Tsukumo, Koji Yasutomo
Summary: Immunoproteasome dysfunction leads to proteasome-associated autoinflammatory syndromes. In a mouse model, Psmb8 mutation causes hyperactivation of the CXCR3 pathway, resulting in increased susceptibility to skin inflammation.
Article
Neurosciences
Yan-Fang Kong, Wei-Lin Sha, Xiao-Bo Wu, Lin-Xia Zhao, Ling-Jie Ma, Yong-Jing Gao
Summary: Chemokines and their receptors play a role in chronic pain pathogenesis, with CXCR3 and CXCL10 specifically influencing neuronal excitability in the dorsal root ganglion. Activation of CXCR3 by CXCL10 leads to p38 and ERK activation in DRG neurons, enhancing neuronal excitability and contributing to neuropathic pain maintenance.
NEUROSCIENCE BULLETIN
(2021)
Article
Surgery
Michael Y. Shino, Jamie L. Todd, Megan L. Neely, Jerry Kirchner, Courtney W. Frankel, Laurie D. Snyder, Elizabeth N. Pavlisko, Gregory A. Fishbein, Joanna M. Schaenman, Kristen Mason, Karen Kesler, Tereza Martinu, Lianne G. Singer, Wayne Tsuang, Marie Budev, Pali D. Shah, John M. Reynolds, Nikki Williams, Mark A. Robien, Scott M. Palmer, S. Sam Weigt, John A. Belperio
Summary: In this study, we investigated the relationship between plasma levels of CXCL9/CXCL10 and histopathologic lung allograft injuries, as well as the risk of developing CLAD. We found that elevated plasma CXCL9/CXCL10 levels were associated with injury patterns associated with CLAD, acute rejection, and acute lung injury, and there was a dose-response relationship between chemokine levels and CLAD risk. Importantly, the presence of elevated plasma chemokines was necessary for the association between histopathologic injury and CLAD. Similar associations and interactions were observed with CXCL9/CXCL10 levels in bronchoalveolar lavage fluid. Elevated plasma CXCL9/CXCL10 during allograft injury may contribute to CLAD development and could be a potential minimally invasive biomarker for immune monitoring.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)