Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells

A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat

(2015) Rong Xu et al.   BMC GENOMICS

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism

(2015) J. L. Izquierdo-Garcia et al.   CANCER RESEARCH

Relationship Between 18F-FDG PET/CT Scans and KRAS Mutations in Metastatic Colorectal Cancer

(2015) K. Kawada et al.   JOURNAL OF NUCLEAR MEDICINE

Plasma Choline Metabolites and Colorectal Cancer Risk in the Women's Health Initiative Observational Study

(2014) S. Bae et al.   CANCER RESEARCH

Tyr-301 Phosphorylation Inhibits Pyruvate Dehydrogenase by Blocking Substrate Binding and Promotes the Warburg Effect

(2014) Jun Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

(2014) D. R. Donohoe et al.   Cancer Discovery

Dietary patterns and risk of colorectal cancer in Tehran Province: a case–control study

(2013) Akram Safari et al.   BMC PUBLIC HEALTH

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Dietary polyamine intake and risk of colorectal adenomatous polyps

(2012) Ashley J Vargas et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Human OCTN2 (SLC22A5) is down-regulated in virus- and nonvirus-mediated cancer

(2012) Mariafrancesca Scalise et al.   CELL BIOCHEMISTRY AND FUNCTION

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Diet and Nutrient Factors in Colorectal Cancer Risk

(2012) Ashley J. Vargas et al.   NUTRITION IN CLINICAL PRACTICE

Kinetics of butyrate metabolism in the normal colon and in ulcerative colitis: the effects of substrate concentration and carnitine on the β-oxidation pathway

(2011) V. De Preter et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research

(2011) Simona M. Ceccarelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Butyrate metabolism in human colon carcinoma cells: Implications concerning its growth-inhibitory effect

(2008) Mireille Andriamihaja et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Real-time polymerase chain reaction quantification of specific butyrate-producing bacteria,DesulfovibrioandEnterococcus faecalisin the feces of patients with colorectal cancer

(2008) Ramadass Balamurugan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY