Article
Biology
Wang-Soo Lee, Woojin Ham, Jaetaek Kim
Summary: NQO1 is an antioxidant flavoprotein that exerts antioxidant activities, anti-inflammatory effects, and interacts with tumor suppressors. Recent studies have highlighted the promising roles of NQO1 in protecting against cardiovascular damage and related diseases.
Article
Nanoscience & Nanotechnology
Haili Zhang, Xiao Xu, Dan Yan, Chunlin Ren, Jinghan Zhang, Mengzhen Gu, Yun Wang, Peiye Wu, Zhongrui Li, Lingyi Kong, Chao Han
Summary: Researchers developed a new nanodrug delivery system (PN) to increase ROS production by degrading the NQO1 protein, leading to enhanced anti-tumor effects. In vitro and in vivo studies demonstrated that PN significantly increased ROS production and exhibited potent antitumor properties. This nanoplatform might provide an alternative approach for treating tumors with NQO1 overexpression.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Engineering, Chemical
Xuewen Mu, Yun Xu, Zheng Wang, Dunyun Shi
Summary: NAD(P)H:quinone oxidoreductase 1 is an enzyme highly expressed in tumors and can be targeted for cancer therapy. Quinone-based bioimaging probes and nanosystems can be used for tumor diagnosis and treatment, improving effectiveness and reducing side effects.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Medicinal
Kuojun Zhang, Kaizhen Wang, Xiangyu Zhang, Zhenlong Qian, Wenbo Zhang, Xiao Zheng, Jiaying Wang, Yin Jiang, Wanheng Zhang, Zhiyu Lu, Haiping Hao, Sheng Jiang
Summary: Targeting NAD(+) metabolism is an effective anticancer strategy. Small molecules that simultaneously target NQO1 and NAMPT were discovered, and one of these compounds, 10d, showed excellent in vivo antitumor efficacy without significant toxicity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Cancan Yang, Zhenling Huang, Xiuguo Zhang, Chunyuan Zhu
Summary: Soluble quinone oxidoreductases facilitate electron transfer from NADPH to quinones for detoxification of synthetic compounds. The crystal structure of NADPH-dependent QOR from Phytophthora capsici (Pc) reveals a bimodular architecture with NADPH-binding grooves and substrate-binding pockets. The enzyme functions as a tetramer in solution and exhibits conserved topology among homologous structures, but with varying substrate specificities. PcQOR prefers catalyzing large substrates like 9,10-phenanthrenequinone, potentially aiding in detoxification of harmful chemicals during invasion by P. capsici.
Article
Chemistry, Multidisciplinary
Naveen J. Roy, Shreyada N. Save, Virender Kumar Sharma, Benchamin Abraham, Abhijith Kuttanamkuzhi, Shilpy Sharma, Mayurika Lahiri, Pinaki Talukdar
Summary: NQO1, a detoxifying enzyme overexpressed in tumors, can protect cancer cells against oxidative stress. The activation of 'protransporter' systems in cancer cells has been achieved using NQO1 activatable quinones, leading to cell apoptosis. The ion transport activity of salicylamides was effectively inhibited by caging the OH group with NQO1-activatable quinones. Activation of the trapped 'protransporters' following reduction by NQO1 was verified. Both the transporters and trapped protransporters exhibited significant toxicity towards MCF-7 breast cancer cells, mediated through oxidative stress, mitochondrial membrane depolarization, and lysosomal deacidification. Induction of cell death via the intrinsic apoptotic pathway was confirmed by monitoring PARP1 cleavage.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Jie Yu, Bingling Zhong, Lin Zhao, Ying Hou, Nana Ai, Jin-Jian Lu, Wei Ge, Xiuping Chen
Summary: Drug resistance is a significant challenge in cancer treatment, and a natural NQO1 substrate called MAM has been found to have a potent anticancer effect. This study aimed to investigate the efficacy of MAM against drug-resistant non-small cell lung cancer. The results showed that MAM induces ferroptosis by targeting NQO1, leading to ROS generation, LIP increase, and lipid peroxidation. Furthermore, MAM significantly suppressed tumor growth in a zebrafish model. These findings provide a novel therapeutic strategy for overcoming drug resistance in NSCLC by inducing NQO1-mediated ferroptosis.
DRUG RESISTANCE UPDATES
(2023)
Article
Oncology
Srimanta Patra, Biswajita Pradhan, Rabindra Nayak, Chhandashree Behera, Laxmidhar Rout, Mrutyunjay Jena, Thomas Efferth, Sujit Kumar Bhutia
Summary: Curcumin and resveratrol, bioactive phytochemicals, have shown promising chemopreventive and chemoprotective effects in cancer therapy. When combined with established anticancer drugs, they enhance anticancer activity while reducing toxicity towards normal organs through improved pharmacokinetics, pharmacodynamics, bioavailability, and metabolism.Development of drug-loaded nanoparticles, nanocarriers, liposomes, and micelles is gaining attention to improve target specificity and drug efficacy in cancer therapeutics.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Evelyn Y. Xue, Fangyuan Kang, Yimin Zhou, Dennis K. P. Ng
Summary: In this study, a far-red-absorbing boron dipyrromethene-based photosensitizer responsive to cancer-associated human NAD(P)H:quinone oxidoreductase 1 was developed, allowing controlled restoration of photodynamic activity for selective elimination of cancer cells.
CHEMICAL COMMUNICATIONS
(2023)
Article
Microbiology
Jiyu Liang, Haiyan Huang, Yubo Wang, Lexin Li, Jihong Yi, Shuning Wang
Summary: Thermotoga maritima is an anaerobic hyperthermophilic bacterium that efficiently produces H-2 by fermenting carbohydrates. The mechanism of sulfur reduction in T. maritima has not been fully understood. In this study, a cytoplasmic NAD(P)H-dependent polysulfide reductase (NSR) from T. maritima was identified and characterized. NSR exhibited S-0, polysulfide, and thiosulfate reduction activities and its expression was upregulated in S-0- or thiosulfate-containing medium. The putative membrane-bound proteins MBX and Rnf may also play a role in the metabolism of T. maritima. These findings highlight the importance of NSR homologs in the sulfur cycle of geothermal environments.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biochemistry & Molecular Biology
Dhruv Sanjay Gupta, Vaishnavi Gadi, Ginpreet Kaur, Meena Chintamaneni, Hardeep Singh Tuli, Seema Ramniwas, Gautam Sethi
Summary: The growing incidence of B cell malignancies worldwide has led to research on the pharmacological properties of phytoconstituents in cancer management. Resveratrol, a polyphenolic stilbenoid found in nature, has shown promising anti-inflammatory and antioxidant properties, making it a potential candidate for managing B cell malignancies. However, more clinical trials in diverse populations are needed to establish its safety and efficacy profile, and exploring nanodelivery methods can enhance its bioavailability. This review provides an overview of the occurrence and pathogenesis of B cell malignancies, the mechanism of actions of resveratrol, results from pre-clinical and clinical studies, and discusses the challenges and future perspectives in the development and use of resveratrol as a therapeutic agent.
Review
Nutrition & Dietetics
Jyothi Dhuguru, Ryan W. W. Dellinger, Marie E. E. Migaud
Summary: Dietary vitamin B3 components have been found to increase NAD(+) levels, which decline with age and disease. Supplementation with NAD(+) biosynthetic intermediates, such as NR and NMN, can effectively raise NAD(+) levels. In addition, inhibiting NAD(+)-consuming enzymes or activating biosynthetic pathways is also a viable approach to increase NAD(+) and NADH. However, the pharmacological significance of NAD(H) catabolites is often overlooked, despite some of these metabolites serving as biomarkers in physiological disorders.
Review
Biochemistry & Molecular Biology
Lukasz Huminiecki
Summary: This paper presents an updated and contextualized literature review on functional genomic studies of natural phenols in the context of cancer. It suggests the multilevel chemopreventive and anticancer mechanisms of action shared by multiple dietary natural phenols. Specifically, evidence is cited for the multilevel anti-cancer effects of curcumin and resveratrol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sudipta Panja, David Siegel, Simonetta Camandola, Rafael de Cabo, David Ross, Krishna M. G. Mallela
Summary: This study explores the pathogenesis of Alzheimer's disease (AD) and finds that the FAD-deficient forms of NQO1 may accelerate the aggregation of Alzheimer's amyloid-beta peptide (A beta(1-42)), shedding light on the development of AD.
BIOSCIENCE REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Sang-Jeong Bae, Sujin Kim, Hyun June Park, Joonwon Kim, Hyunbin Jin, Byung-gee Kim, Ji-Sook Hahn
Summary: The study achieved an increase in acetoin production through adaptive laboratory evolution and elimination of byproducts. By identifying Ora1, Ypr1, and Ara1 as contributors to byproduct formation, further optimization of (R)-acetoin production was achieved.
METABOLIC ENGINEERING
(2021)
Article
Chemistry, Medicinal
Mohamed Hagras, Haroon Mohammad, Mohamed S. Mandour, Youssef A. Hegazy, Adel Ghiaty, Mohamed N. Seleem, Abdelrahman S. Mayhoub
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Haroon Mohammad, Waleed Younis, Lu Chen, Christine E. Peters, Joe Pogliano, Kit Pogliano, Bruce Cooper, Jianan Zhang, Abdelrahman Mayhoub, Eric Oldfield, Mark Cushman, Mohamed N. Seleem
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Ahmed Kotb, Nader S. Abutaleb, Mohamed A. Seleem, Mohamed Hagras, Haroon Mohammad, Ashraf Bayoumi, Adel Ghiaty, Mohamed N. Seleem, Abdelrahman S. Mayhoub
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Mohamed Hagras, Youssef A. Hegazy, Amr H. Elkabbany, Haroon Mohammad, Adel Ghiaty, Tamer M. Abdelghany, Mohamed N. Seleem, Abdelrahman S. Mayhoub
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Moustafa ElAwamy, Haroon Mohammad, Abdelrahman Hussien, Nader S. Abutaleb, Mohamed Hagras, Rabah A. T. Serya, Azza T. Taher, Khaled A. M. Abouzid, Mohamed N. Seleem, Abdelrahman S. Mayhoub
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Huy X. Ngo, Keith D. Green, Chathurada S. Gajadeera, Melisa J. Willby, Selina Y. L. Holbrook, Caixia Hou, Atefeh Garzan, Abdelrahman S. Mayhoub, James E. Posey, Oleg Tsodikov, Sylvie Garneau-Tsodikova
ACS INFECTIOUS DISEASES
(2018)
Article
Chemistry, Medicinal
Mohamed Hagras, Nader S. Abutaleb, Alsagher O. Ali, Jelan A. Abdel-Aleem, Mohamed M. Elsebaei, Mohamed N. Seleem, Abdelrahman S. Mayhoub
ACS INFECTIOUS DISEASES
(2018)
Article
Chemistry, Medicinal
Mohamed M. Elsebaei, Nader S. Abutaleb, Abdulrahman A. Mahgoub, Daoyi Li, Mohamed Hagras, Haroon Mohammad, Mohamed N. Seleem, Abdelrahman S. Mayhoub
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Ahmed Mancy, Nader S. Abutaleb, Mohamed M. Elsebaei, Abdullah Y. Saad, Ahmed Kotb, Alsagher O. Ali, Jelan A. Abdel-Aleem, Haroon Mohammad, Mohamed N. Seleem, Abdelrahman S. Mayhoub
ACS INFECTIOUS DISEASES
(2020)
Article
Chemistry, Medicinal
Yomna Hosny, Nader S. Abutaleb, Mariam Omara, Marwa Alhashimi, Mohamed M. Elsebaei, Heba S. Elzahabi, Mohamed N. Seleem, Abdelrahman S. Mayhoub
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Mohamed Hagras, Ehab A. Salama, Ahmed M. Sayed, Nader S. Abutaleb, Ahmed Kotb, Mohamed N. Seleem, Abdelrahman S. Mayhoub
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Mohamed M. Elsebaie, Hanzada T. Nour El-Din, Nader S. Abutaleb, Abdelrahman A. Abuelkhir, Hsin-Wen Liang, Ahmed S. Attia, Mohamed N. Seleem, Abdelrahman S. Mayhoub
Summary: A series of diphenylurea derivatives with aminoguanidine moiety were synthesized and their antibacterial activity was evaluated. Two compounds showed better bacteriological profiles and prolonged post-antibiotic effect. Additionally, these compounds were able to resensitize vancomycin-resistant strains and exhibited comparable efficacy to a commercially available drug in a mouse model. Therefore, the diphenylurea scaffold has potential as an anti-staphylococcal treatment option.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hanzada T. Nour T. El-Din, Mohamed M. Elsebaie, Nader S. Abutaleb, Ahmed M. M. Kotb, Ahmed S. Attia, Mohamed N. Seleem, Abdelrahman S. Mayhoub
Summary: In this study, a series of structurally related acetylenic-diphenylurea derivatives carrying the aminoguanidine moiety were tested for their antibacterial efficacy against multidrug-resistant Gram-positive clinical isolates. Compound 18 showed superior bacteriological characteristics compared to the lead compound I. In addition, compound 18 demonstrated excellent in vitro antibacterial profile, high tolerability towards mammalian cells, and significant effectiveness in controlling MRSA infection in an animal model.
RSC MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Ahmed M. Helal, Ahmed M. Sayed, Mariam Omara, Mohamed M. Elsebaei, Abdelrahman S. Mayhoub
Article
Chemistry, Multidisciplinary
Ahmed Kotb, Nader S. Abutaleb, Mohamed Hagras, Ashraf Bayoumi, Mahmoud M. Moustafa, Adel Ghiaty, Mohamed N. Seleem, Abdelrahman S. Mayhoub
