Article
Biochemistry & Molecular Biology
Zahra Zareshahrabadi, Mohammad Khorram, Keyvan Pakshir, Ali-Mohammad Tamaddon, Mahboobeh Jafari, Hasti Nouraei, Niloofar Torabi Ardekani, Neda Amirzadeh, Cambyz Irajie, Alireza Barzegar, Aida Iraji, Kamiar Zomorodian
Summary: This study aimed to develop a novel and cost-effective IONPs@CS-AmB formulation to enhance AmB delivery performance and reduce drug dosage and adverse effects. The results showed that IONPs@CS-AmB exhibited significant antifungal activity and had higher biocompatibility compared to plain AmB and fungizone.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
B. N. Harish, S. N. Nagesha, B. N. Ramesh, S. Shyamalamma, M. S. Nagaraj, H. C. Girish, C. Pradeep, K. S. Shiva Kumar, K. S. Tharun Kumar, S. N. Pavan, V. Kavan Kumar
Summary: This study investigated the antifungal activities of lipopeptides from different B. subtilis strains against Alternaria alternata, and found that the T6 strain showed the highest antifungal activity with a suppression rate of 85.88%.
Article
Food Science & Technology
Santosh Pradhan, Laxmi Ananthanarayan, Kalyani Prasad, Pooja Bhatnagar-Mathur
Summary: Several bacterial isolates with antagonistic effects against Aspergillus spp. were screened from South Indian idli batter and fermented foods, with some isolates closely related to specific bacterial species. The cell free supernatants from these isolates showed significant antifungal activity in peanuts and effectively suppressed the production of aflatoxin B1.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marco Masi, Mariagioia Petraretti, Antonino De Natale, Antonino Pollio, Antonio Evidente
Summary: This study evaluated three fungal metabolites as potential antifungal compounds against damaging fungi isolated from Roman remains in Italy. Two of the metabolites showed antifungal activity against Aspergillus niger and Fusarium oxysporum, indicating their potential for preservation of artworks and archaeological sites.
Review
Microbiology
Nancy N. Vuong, Danielle Hammond, Dimitrios P. Kontoyiannis
Summary: The role of inhaled antifungals for prophylaxis and treatment of invasive fungal pneumonias in certain high-risk groups has not been clearly defined. Recent literature suggests that inhaled liposomal amphotericin B could be an alternative prophylactic option for neutropenic populations at high risk for invasive fungal pneumonia, where systemic triazoles are not tolerated. Inhaled amphotericin B is commonly used for prophylaxis in lung transplant recipients and shows promise in preventing fungal pneumonias secondary to viral pneumonias, influenza, and SARS CoV-2. Limited data are available for the adjunct treatment of inhaled amphotericin, but its utility is feasible.
Article
Biochemistry & Molecular Biology
Jian Wu, Jinzhe Chang, Jun Liu, Jiajian Huang, Zixia Song, Xiaofeng Xie, Liting Wei, Jiaxin Xu, Suqing Huang, Dongmei Cheng, Youzhi Li, Hanhong Xu, Zhixiang Zhang
Summary: A chitosan-based nanoparticle with superior antifungal activity and adhesion performance was prepared. It is of great significance for the development and application of biocompatible chitosan-based nanopesticides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Suvi T. Hakkinen, Marina Sokovic, Liisa Nohynek, Ana Ciric, Marija Ivanov, Dejan Stojkovic, Irina Tsitko, Melanie Matos, Joao P. Baixinho, Viktoriya Ivasiv, Naiara Fernandez, Claudia Nunes dos Santos, Kirsi-Marja Oksman-Caldentey
Summary: Chicory contains bioactive compounds with antimicrobial, antifungal, and antibiofilm activities. Supercritical fluid extracts showed the highest bioactivity, inhibiting drug-resistant bacteria and fungi. There is potential for the development of novel antibacterial and antifungal preparations from chicory extracts.
Article
Chemistry, Medicinal
Ondrej Stepanek, Adela Cmokova, Eliska Prochazkova, Valeria Grobarova, Jan Cerny, Martina Slapnickova, Alena Zikova, Miroslav Kolarik, Ondrej Baszczynski
Summary: This study aims to develop suitable linkers for enhancing the antifungal activity of ketoconazole. By introducing structural modifications to the ketoconazole molecule, its effectiveness against pathogenic fungi and trypanosomes can be improved.
Article
Immunology
Rong Jiao, Yongzhan Cai, Pengfei He, Shahzad Munir, Xingyu Li, Yixin Wu, Junwei Wang, Mengyuan Xia, Pengbo He, Ge Wang, Huanwen Yang, Samantha C. Karunarathna, Yan Xie, Yueqiu He
Summary: Bacillus amyloliquefaciens YN201732 has been found to have significant antifungal activity against tobacco powdery mildew, with bacillomycin D and fengycin playing potential roles in this process. However, gene mutations related to lipopeptide synthesis may also impact the biofilm formation of strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Nivedhitha Kabeerdass, Ahmed Al Otaibi, Manikandan Rajendran, Ayyar Manikandan, Heba A. Kashmery, Mohammed M. Rahman, P. Madhu, Anish Khan, Abdullah M. Asiri, Maghimaa Mathanmohun
Summary: The supernatant of soil-borne pathogen Bacillus mn14 was used as a catalyst for the synthesis of silver nanoparticles (AgNPs), which showed antibacterial and antifungal activities. The AgNPs demonstrated potential in inhibiting S. viridans and R. solani. Various characterization techniques confirmed the properties of the AgNPs, suggesting a promising approach for disease treatment and agricultural applications.
Article
Food Science & Technology
Mine Aslan, Nilgun Ertas, M. Kursat Demir
Summary: This study investigated the characteristics of liposomes encapsulated with ethanolic extracts of Cinnamomum verum, Curcuma longa, Zingiber officinale, Syzygium aromaticum and Laurus nobilis. The liposomes showed strong antifungal activity and good encapsulation efficiency. The thermal stability and release properties varied among the different extract-loaded liposomes.
Review
Chemistry, Medicinal
Katarzyna Sulkowska-Ziaja, Monika Trepa, Aldona Olechowska-Jarzab, Pawel Nowak, Marek Ziaja, Katarzyna Kala, Bozena Muszynska
Summary: Fungi are a promising source of antimicrobial compounds with antibacterial, antifungal, and antiviral activity. These compounds can serve as alternatives to antibiotics and can also be utilized in the field of cosmetology.
Article
Pharmacology & Pharmacy
Zhuang Li, Na Liu, Wanzhen Yang, Jie Tu, Yahui Huang, Wei Wang, Chunquan Sheng
Summary: The first light-responsive antifungal agents were designed by controlling the fungal ergosterol biosynthesis pathway with photocaged triazole lanosterol 14α-demethylase inhibitors. The light-activated compound showed efficient recovery of antifungal activity after shielding and activation. These new chemical tools enable precise regulation of fungal growth, morphology, and biofilm formation. In vivo models demonstrated the efficacy of these light-activated compounds in prolonging survival and reducing fungal burden.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Materials Science, Paper & Wood
Sherin Philip, Sunny Kuriakose
Summary: The study aimed at developing a new nano drug delivery system with superparamagnetic, fluorescent, non-cytotoxic, and antifungal properties. The system was found to be non-cytotoxic and displayed effective antifungal capabilities against Histoplasma capsulatum and Trichophyton rubrum.
Article
Microbiology
Kevin Brunet, Cheikh A. B. Diop, Alexia Chauzy, Noemie Prebonnaud, Sandrine Marchand, Blandine Rammaert, Frederic Tewes
Summary: This study evaluated the effect of the combination of amphotericin B (AmB) and various non-ionic surfactants on the activity of AmB against Mucorales, the toxicity on eukaryotic cells, and the modification of AmB aggregation states. The results showed that PEG15HS increased the efficacy of AmB against Mucorales without increasing its toxicity.
Article
Biochemical Research Methods
Kate Lansdown, Katrina A. Jolliffe, Helen Salouros
Summary: Stable isotope ratio mass spectrometry can be used to determine the precursor and precursor origin of methylamphetamine drug samples. Through different drug profiling techniques, methylamphetamine samples of different P2P origins can be distinguished.
DRUG TESTING AND ANALYSIS
(2022)
Article
Cell Biology
Badwi B. Boumelhem, Chelsea Pilgrim, Vincent E. Zwicker, Jacek L. Kolanowski, Jia Hao Yeo, Katrina A. Jolliffe, Elizabeth J. New, Margot L. Day, Stephen J. Assinder, Stuart T. Fraser
Summary: This article describes a simple and inexpensive method to determine lipid content in cells, and highlights the differences in lipid biology between cell types using imaging and flow cytometry.
JOURNAL OF CELL SCIENCE
(2022)
Editorial Material
Chemistry, Organic
Katrina (Kate) A. Jolliffe, Philip A. Gale
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Cell Biology
Harikrishnan Balachandran, Chansavath Phetsouphanh, David Agapiou, Anurag Adhikari, Chaturaka Rodrigo, Mohamed Hammoud, Lok Bahadur Shrestha, Elizabeth Keoshkerian, Money Gupta, Stuart Turville, Daniel Christ, Cecile King, Sarah C. Sasson, Adam Bartlett, Branka Grubor-Bauk, William Rawlinson, Anupriya Aggarwal, Alberto Ospina Stella, Vera Klemm, Michael M. Mina, Jeffrey J. Post, Bernard Hudson, Nicky Gilroy, Pam Konecny, Golo Ahlenstiel, Dominic E. Dwyer, Tania C. Sorrell, Anthony Kelleher, Nicodemus Tedla, Andrew R. Lloyd, Marianne Martinello, Rowena A. Bull
Summary: This study examines the long-term maintenance of immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its association with disease severity and early immune responses. The findings show that most individuals with severe infection maintain stable humoral immune responses and neutralizing antibodies against variants of concern, including the Delta variant. Modeling the immune responses suggests a significant level of protection against symptomatic infection. The study also highlights the importance of baseline antigen-specific CD4+ T cell responses in predicting the maintenance of antibody neutralization and memory B cell levels.
Editorial Material
Chemistry, Multidisciplinary
Jennifer S. Leigh, Jennifer R. Hiscock, Sarah Koops, Anna J. McConne, CaIly J. E. Haynes, Claudia Caltagirone, Marion Kieffer, Emily R. Draper, Anna G. Slater, Kristin M. Hutchins, Davita Watkins, Nathalie Busschaert, Larissa K. S. von Krbek, Katrina A. Jolliffe, Michaele J. Hardie
Summary: The international Women in Supramolecular Chemistry network believes that an area-specific approach effectively supports equality, diversity, and inclusion. This study shares the impact of COVID-19 in this field by combining findings from an online survey, a collaborative autoethnography, and reflective group research meetings. The results demonstrate that qualitative research with the community provides insights into challenges and supports individuals. Additionally, it shows that research leaders often prioritize the mental health and well-being of their teams at the expense of their own.
Article
Infectious Diseases
Adam J. Svahn, Sheryl L. Chang, Rebecca J. Rockett, Oliver M. Cliff, Qinning Wang, Alicia Arnott, Marc Ramsperger, Tania C. Sorrell, Vitali Sintchenko, Mikhail Prokopenko
Summary: By combining whole-genome data with network analysis, the resolution of population analysis of foodborne pathogens can be improved, enhancing monitoring capabilities. The high concordance between network components and SNP clusters shows promise for rapid population analysis of foodborne Salmonella spp.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Stephen Morrell, Maija R. J. Kohonen-Corish, Robyn L. Ward, Tania C. Sorrell, David Roder, David C. Currow
Summary: This study aimed to investigate the association between antibiotic exposure before cancer treatment and cancer survival. The results showed that antibiotic exposure within 180 days before non-immune checkpoint inhibitor systemic therapy was associated with poorer cancer survival, particularly for patients with lung and breast primaries.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Immunology
Anurag Adhikari, Arunasingam Abayasingam, Chaturaka Rodrigo, David Agapiou, Elvis Pandzic, Nicholas A. Brasher, Bentotage Samitha Madushan Fernando, Elizabeth Keoshkerian, Hui Li, Ha Na Kim, Megan Lord, Gordona Popovic, William Rawlinson, Michael Mina, Jeffrey J. Post, Bernard Hudson, Nicky Gilroy, Dominic Dwyer, Sarah C. Sasson, Branka Grubor-Bauk, Andrew R. Lloyd, Marianne Martinello, Rowena A. Bull, Nicodemus Tedla
Summary: A study on acute and convalescent COVID-19 patients found that early phagocytic responses are primarily driven by heat-liable components in plasma, while convalescent patients' phagocytosis is largely dependent on anti-Spike IgG titers. Longitudinal analysis showed an increase in antibody affinity, correlating with the maintenance of phagocytic and neutralization functions, indicating an improvement in antibody quality.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Nikki A. Tzioumis, Duncan A. Cullen, Katrina A. Jolliffe, Nicholas G. White
Summary: A simple biphenyl bis-amidinium compound (1.Cl-2) can selectively precipitate sulfate from water even at low concentrations. It shows complete selectivity against monovalent anions and high selectivity even against CO32- and HPO42-. It is highly effective in removing sulfate (>90%) from both seawater and highly acidic conditions relevant to mining waste-streams. X-ray crystallography reveals the structure of 1.SO4 with tightly packed, anhydrous arrangement where each sulfate anion receives eight hydrogen bonds from amidinium N-H hydrogen bond donors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Microbiology
Justin Beardsley, Aiken Dao, Caitlin Keighley, Katherine Garnham, Catriona Halliday, Sharon C. -A. Chen, Tania C. Sorrell
Summary: Cryptococcus species are a significant cause of life-threatening infections, with Cryptococcus neoformans being the most common, and Cryptococcus gattii responsible for a significant number of cases worldwide. Despite optimal treatment, C. gattii infections have high early mortality rates. The lack of effective therapies and robust clinical and epidemiological data led to the classification of C. gattii as a medium-priority pathogen on the Fungal Priority Pathogen List released by the World Health Organization. This review summarizes the latest research on the taxonomy, epidemiology, pathogenesis, laboratory testing, and management of C. gattii infections.
Article
Chemistry, Multidisciplinary
Claire E. Flitcroft, Katrina A. Jolliffe, Christopher S. P. McErlean
Summary: Late-stage functionalisation is an attractive method for generating peptide analogues with non-natural residues. Cysteine residues can be activated as Crich-type thioethers, either by alkylation of a synthetic cysteine-continuing peptide or by incorporating a modified cysteine unit into solid phase or solution phase peptide synthesis. Photoredox catalysed reaction of the thioether generates a stereoretentive and site-selective alanyl radical intermediate, which can react with non-activated alkenes to form non-natural residues bearing aliphatic, hydrophobic units. A method to avoid unwanted alkylation of amine residues was identified and successfully applied to functionalizing both linear and cyclic synthetic peptides.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
Tania C. Sorrell, Martin Hensher, Lena A. Sanci
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Health Care Sciences & Services
J. M. Basseal, C. M. Bennett, P. Collignon, B. J. Currie, D. N. Durrheim, J. Leask, E. S. McBryde, P. McIntyre, F. M. Russell, D. W. Smith, T. C. Sorrell, B. J. Marais
Summary: Australia avoided the worst effects of COVID-19 pandemic, but still faced negative impacts. Lessons from Australia's public health response include the effectiveness of movement restrictions with careful consideration of adverse impacts, the value of disease modeling while acknowledging its limitations, the need for timely national data for reassessment of surveillance structures, the utility of advanced pathogen genomics and novel vaccine technology, the importance of evidence-informed and consultative decisionmaking, addressing major weaknesses in the aged-care sector, adequate infection prevention and control frameworks, prioritizing the interests of young people, recognizing epidemics as a standing threat, and fostering regional and global solidarity.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Chemistry, Organic
Jakob D. E. Lane, Katrina A. Jolliffe
Summary: A series of fluorophore-containing squaramides were synthesized to study their fluorescent and colorimetric response to anions. Squaramides with conjugated fluorophores showed complex fluorescence behavior and color changes upon addition of anions due to the presence of highly acidic NH protons. However, squaramides with an electronically insulated fluorophore gave a simpler fluorescence response attributed to a decrease in excimer emission, resulting in a ratiometric fluorescent response to anions. The most selective molecules demonstrated a preference for binding to sulfate over other anions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jakob D. E. Lane, William J. H. Greenwood, Victor W. Day, Katrina A. Jolliffe, Kristin Bowman-James, Louis Adriaenssens
Summary: 1,1'-Bis[squaramido]ferrocenes (FcSq(2)) are introduced as electrochemically active scaffolds for sulfate recognition. FcSq(2) shows high affinity and selectivity towards sulfate in aqueous DMSO mixtures. The unique electrochemical response of FcSq(2) enables selective detection of sulfate.
NEW JOURNAL OF CHEMISTRY
(2022)
