Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Engineering, Biomedical
Yong Hwa Hwang, Youn-Jung Kim, Dong Yun Lee
Summary: The study suggests that UFH-coated SPIO nanoparticles could potentially serve as an alternative negative contrast agent with lower toxicity and better biocompatibility compared to dextran-coated SPIO nanoparticles.
BIOMATERIALS RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Zhenbo Sun, Mingfang Luo, Jia Li, Ailing Wang, Xucheng Sun, Qiong Wu, Kaiyue Li, Ying Ma, Caixia Yang, Xianglin Li
Summary: The study demonstrates that SCFs nanoparticles can serve as effective drug delivery vehicles for photodynamic therapy with extremely high loading efficiency. In vitro and in vivo experiments show that SCFs selectively accumulate in tumor cells, inducing cell death under near-infrared laser irradiation, and efficiently ablating tumors with minimal side effects.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Kubra Nur Ozvural Sertcelik, Osman Karaman, Toghrul Almammadov, Gorkem Gunbas, Safacan Kolemen, Havva Yagci Acar, Kubra Onbasli
Summary: Development of targeted nanoparticles as carriers to deliver photosensitizers to cancer cells is highly beneficial for ensuring the expected therapeutic outcome of photodynamic therapy. In the study, Cet-PAA@SPION/BOD-Se-I showed significantly enhanced phototoxicity on colon cancer cells and completely eliminated phototoxicity on healthy cells.
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Chemistry, Multidisciplinary
Daisuke Tsuji, Atsushi Nakayama, Riko Yamamoto, Shuji Nagano, Takashi Taniguchi, Ryota Sato, Sangita Karanjit, Naoki Muguruma, Tetsuji Takayama, Kohji Itoh, Kosuke Namba
Summary: This study investigated the photo-induced cytotoxicities of various TAP derivatives. Among the derivatives, 2-p-nitrophenyl-TAP showed significant cytotoxicity to HeLa cells under UV irradiation but no cytotoxicity without UV. In addition, the photo-induced cytotoxicity of 2-p-nitirophenyl-TAP was found to be cancer cell selective and effective against HeLa cells and HCT 116 cells. Therefore, small molecule dyes with selective and efficient photo-induced cytotoxicity have been developed.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Tingting Zhang, Zhijie Wang, Huijing Xiang, Xue Xu, Jing Zou, Chichong Lu
Summary: This study successfully synthesized water-soluble and biocompatible EuIO NCs with enhanced contrast enhancement in MRI, as well as functionalized EuIO NCs exhibiting excellent fluorescence imaging performance in vivo. The research provides a simple strategy for the design and construction of a novel multifunctional magnetic nanoplatform, offering solutions for the development of multimodal imaging probes and disease diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Xiaolong Liang, Min Chen, Pravin Bhattarai, Sadaf Hameed, Yida Tang, Zhifei Dal
Summary: The study presents a theranostic nanoplatform based on Fe3O4@PGL NPs, which showed outstanding therapeutic effects against cancer cells through excellent self-assembling nature, high loading of porphyrins, and photodynamic effects.
Article
Chemistry, Physical
Jun Wang, Xinyi Zhu, Wei Pei, Liuzhu Zhou, Ling Cai, Huijun Jiang, Jin Chen
Summary: A recyclable bactericide, SPIO/ZnO NPs, with desirable biocompatibility efficiently inhibits the growth of S. aureus and E. coli, showing bactericidal activities retained for four cycles. The mechanistic studies revealed the damaging role of the nanocomposite to bacteria cells through tight attachment on the cell membrane and regulated release of Zn2+. The produced recyclable SPIO/ZnO NPs hold potentials for practical applications with negligible development of bacterial resistance.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Biophysics
E. V. Dukhopelnykov, Yu. N. Blyzniuk, A. A. Skuratovska, E. G. Bereznyak, N. A. Gladkovskaya
Summary: This study investigated the interaction between superparamagnetic iron oxide nanoparticles (SPIONs) and doxorubicin (DOX) and DNA. The results showed that the nanoparticles do not interact with DNA, but can load a large number of DOX molecules. At high DNA concentrations, almost all DOX molecules bind to DNA.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Mona Kappes, Bernhard Friedrich, Felix Pfister, Christian Huber, Ralf Phillipp Friedrich, Rene Stein, Christian Braun, Julia Band, Eveline Schreiber, Christoph Alexiou, Christina Janko
Summary: Noncontact manipulation of cells in regenerative medicine using superparamagnetic iron oxide nanoparticles (SPIONs) allows for new possibilities in tissue engineering. SPIONs can be used as drug transporters, contrast agents, or to make cells maneuverable by magnetic forces. Different SPION coatings, such as PAM and citrate, show good cellular loading and magnetic controllability of cells. This research demonstrates the potential for using SPIONs in 3D cell cultures and highlights their ability to accelerate spheroid formation and micropatterning.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Korobi Konwar, Niyorjyoti Sharma, Pranjali Pranjali, Anupam Guleria, Som Datta Kaushik, Anupam Dutta, Rupak Mukhopadhyay, Debasis Sen, Weibo Gao, Pritam Deb
Summary: The study aims to explore the relationship between structure and relaxivity by observing transverse relaxivity enhancement in MRI of differently organized superparamagnetic complex ensembles. The spatial arrangement of nanoparticles, magnetic easy axes, and anisotropy energy landscape were found to affect transverse relaxation. The research simplifies the limitation of the quantum mechanical outer-sphere diffusion model of MR relaxivity.
Article
Multidisciplinary Sciences
Qiang Liu, Song Chen, Liguo Hao, Chunxiang Li, Hongda Tian, Hongqian Gu, Zhongtao Li, Lei Wang, Zhongyuan Li
Summary: By successfully synthesizing the USPIO-PEG-Cy5.5 targeted bimodal probe, the goal of noninvasive diagnosis of thyroid cancer was achieved. The probe exhibits low toxicity, good biocompatibility, and a stable particle size, showing promising potential for clinical applications.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2022)
Review
Nanoscience & Nanotechnology
Hao Wei, Yangnan Hu, Junguo Wang, Xia Gao, Xiaoyun Qian, Mingliang Tang
Summary: Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively studied and utilized in biomedicine due to their superb superparamagnetic properties and reliable traceability. However, different SPIONs exhibit variations in cytotoxicity, metabolism, and cellular behaviors. A comprehensive review of the construction and application of SPIONs is necessary to address these differences.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Aile Tamm, Aivar Tarre, Jekaterina Kozlova, Mihkel Rahn, Taivo Jogiaas, Tauno Kahro, Joosep Link, Raivo Stern
Summary: The study presents a strategy to fabricate a nanostructure composed of superparamagnetic thin films, by depositing ruthenium-doped iron oxide thin films using atomic layer deposition at different temperatures. The doping of ruthenium helps to lower the formation temperature of hematite, resulting in nano-crystalline hematite structure with superparamagnetic behavior observed in the films.
Article
Polymer Science
Sherin Philip, Sunny Kuriakose, Tessymol Mathew
Summary: The study focused on synthesizing and characterizing fluorescently modified beta-cyclodextrin (CD) by covalently immobilizing Pyrene butyric acid (PBA) onto supramolecular CD via Steglich esterification. The fluorescently modified CD-PBA conjugate was further encapsulated with iron (III) oxide nanoparticles (IONP). The three systems PBA, CD-PBA, and CD-PBA-IONP were well characterized and compared for their photoresponsive and thermal properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Sherin Philip, Sunny Kuriakose
Summary: The present study aimed to improve the thermal characteristics of different types of capping agents by incorporating iron oxide nanoparticles. Iron oxide nanocomposites were prepared using a simple reduction protocol followed by air oxidation. Three different biocompatible capping agents, supramolecular beta-cyclodextrin, dendritic hyperbranched polyglycerol, and macromolecular starch, were used. The chemical nature of the composites was confirmed by spectroscopy. The thermal behavior of the pure capping agents and their nanoparticle-incorporated composites was analyzed using TG/DTG and DSC measurements. Incorporation of iron oxide nanoparticles increased the thermal stability of the capping agents and prevented their melting, making them suitable for various applications.
