Targeting Multidrug Resistance with Small Molecules for Cancer Therapy

Synthesis and Biological Evaluation of Decursin, Prantschimgin and Their Derivatives

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

First biological evaluation of developed 3-benzyloxyfluorenes as novel class of MDR modulators

(2010) Martin Krug et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationships Studies in a Series ofN,N-Bis(alkanol)amine Aryl Esters as P-Glycoprotein (Pgp) Dependent Multidrug Resistance (MDR) Inhibitors†

(2010) Cecilia Martelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives

(2009) Kyung Hoon Min et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity

(2009) Hans-Georg Häcker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antimultidrug resistance evaluation of icariin and its derivatives

(2009) Dong-Fang Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from thep-Glycoprotein (ABCB1) Modulator Tariquidar

(2009) Matthias Kühnle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aromatic 2-(Thio)ureidocarboxylic Acids As a New Family of Modulators of Multidrug Resistance-Associated Protein 1: Synthesis, Biological Evaluation, and Structure−Activity Relationships

(2009) Hans-Georg Häcker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Methoxylation of 3′,4′-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells

(2008) Wang-Fun Fong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: A novel series of highly potent revertants of P-glycoprotein associated multidrug resistance

(2008) Umashankar Das et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer

(2008) Yu Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

(2008) Suneet Shukla et al.   Expert Opinion on Drug Metabolism & Toxicology

2-[(3-Methoxyphenylethyl)phenoxy]-Based ABCB1 Inhibitors: Effect of Different Basic Side-Chains on Their Biological Properties

(2008) Nicola Antonio Colabufo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of (Hetero)Arylmethyloxy- and Arylmethylamine-phenyl Derivatives as Potent P-glycoprotein Modulating Agents

(2008) Nicola Antonio Colabufo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Insight in Structure−Activity Relationship and Bioanalysis of P-Glycoprotein Targeting Highly Potent Tetrakishydroxymethyl Substituted 3,9-Diazatetraasteranes

(2008) Claudius Coburger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of MDR1 Activity in Vitro by a Novel Class of Diltiazem Analogues: Toward New Candidates

(2008) Maurizio Viale et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells

(2008) Katarzyna Skupień et al.   PHYTOTHERAPY RESEARCH

P-Glycoprotein Inhibitory Activity of Lipophilic Constituents of Echinacea pallida Roots in a Human Proximal Tubular Cell Line

(2008) Nadia Romiti et al.   PLANTA MEDICA