Journal
PHYTOTHERAPY RESEARCH
Volume 22, Issue 5, Pages 689-694Publisher
WILEY
DOI: 10.1002/ptr.2411
Keywords
berry plants; leaf extracts; phenolic compounds; human promyelocytic HL60 cells; multidrug resistance MDR; in vitro antileukaemic activity
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The aim of the present study was to determine in vitro antileukaemic activities of extracts obtained from chokeberry (Aronia melanocarpa [Michx] Elliot) and mulberry (Morus alba L.) leaves against promyelocytic HL60 cell line and its multidrug resistant sublines exhibiting two different MDR phenotypes: HL60/ VINC (overexpressing P-glycoprotein) and HL60/DOX (overexpressing MRP1 protein). It was found that the extracts from chokeberry and mulberry leaves were active against the sensitive leukaemic cell line HL60 and retained the in vitro activity against multidrug resistant sublines (HL60/VINC and HL60/DOX). The values of resistance factor (RF) found for these extracts were very low lying in the range 1.2-1.6. Copyright (C) 2008 John Wiley & Sons, Ltd.
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