Article
Engineering, Electrical & Electronic
Jian Chen, Jiahao Yin, Xiaoshuai An, Liang Chen, Ling Zhu, Kwai Hei Li
Summary: A novel GaN-based microchip for sugar concentration detection is reported. The microchip, fabricated on a GaN-on-sapphire chip, allows for optical coupling without external optics. It exhibits real-time monitoring and detection capabilities for honey adulteration, with a small footprint, high compactness, low cost, and ease of operation, making it suitable for practical applications.
IEEE SENSORS JOURNAL
(2022)
Review
Chemistry, Analytical
Xiaowen Ou, Peng Chen, Bi-Feng Liu
Summary: Cell analysis at the single-cell level is crucial for understanding the heterogeneity within cell populations and the characteristics of individual cells. Microfluidic chip systems have been widely used for single-cell analysis due to their precise manipulation and sensitive detection capabilities. This review focuses on the optical technologies used in single-cell analysis on microfluidic chip systems, including fluorescence, surface-enhanced Raman spectroscopy, surface plasmon resonance, and interferometry. The recent applications and future directions of these optical technologies are discussed.
Article
Chemistry, Analytical
Xue-song Shi, Yu-fan Zhao, Hong-ye Zhang, Xue-feng Xu
Summary: Recent progress in wettability-patterned microchips has facilitated ultra-trace detection in multiple biomedical and food safety fields. This paper reports an integrated design, fabrication, and evaporation strategy to avoid wettability transition and achieve high-performance surface-enhanced Raman scattering (SERS) detection.
Article
Engineering, Electrical & Electronic
Jiacheng Sun, Tao Wang, Zeinab Jafari, Fei Gao, Xiao Lin, Hongsheng Chen, Gaofeng Wang, Israel De Leon
Summary: Plasmonic lasers provide a paradigm-changing approach for generating coherent light at the nanoscale, with high sensitivity to the surrounding environment for potential use in high-performance sensing devices. The proposed plasmonic laser architecture based on a high-Q plasmonic crystal shows excellent surface sensing properties, surpassing previously reported high-performance plasmonic biosensor architectures.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Article
Chemistry, Analytical
Yi Duan, Chuanliang Wang, Xuhui Geng, Guiqiu Wang, Yafeng Guan
Summary: A highly sensitive optical fiber-based laser-induced fluorescence (LIF) detector was developed for in-vitro parathyroid gland (PG) identification. By designing a special optical fiber probe and adding a dichroic mirror module, the sensitivity was increased and the noise was reduced, leading to more accurate detection results.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Dmitriy Sotnikov, Nadezhda A. Byzova, Anatoly Zherdev, Boris B. Dzantiev
Summary: The study presents a method based on fluorescence registration to measure the number of antibodies and their antigen-binding properties in antibody-nanoparticle conjugates, as well as to validate the reliability and effectiveness of gold nanoparticle preparations.
Article
Chemistry, Analytical
Ya-Mei Peng, Jian-Zhang Pan, Qun Fang
Summary: Miniaturized LIF detectors with three optical configurations were developed and tested for detection limits of sodium fluorescein. A handheld orthogonal LIF detector was successfully built with small size, moderate cost, and low detection limit for field analysis applications.
Article
Engineering, Electrical & Electronic
Hiroto Kawakami, Shoichiro Kuwahara, Yoshiaki Kisaka
Summary: This study investigates random intensity noises in forward-pumped distributed Raman amplifier systems, showing characteristics of pump-to-signal intensity noise transfer and proposing solutions for noise induced in pump light. A novel optical depolarizer for pump light is introduced to manage optical phases and suppress gain instability. Measurement results demonstrate improved 16-QAM transmission specifications with acceptable noise levels during operation.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Optics
Xinyan Yang, Xin Wang, Xi Wang, Biyi Wang, Dongdong Li, Xu Zhang, Hongmei Ren, Hengbo Qin, Zhengxian Zhou, Xianfeng Zheng
Summary: A method using laser-induced breakdown spectroscopy (LIBS) for monitoring the extent of eutrophication in water was proposed. By applying plasma amplification, the performance of LIBS detection of phosphorus in water was improved, resulting in decreased detection limit, relative error, and root mean square error.
Article
Chemistry, Analytical
Lipeng Pan, Mingye Zou, Fangxing Ma, Lingqing Kong, Changnan Zhang, Likun Yang, Anna Zhu, Feng Long, Xiang-Yang Liu, Naibo Lin
Summary: A compact evanescent wave detection platform is developed for the detection of fluorescence gold nanoclusters. The platform employs a simple optical system and a Si-based photodetector assembly, improving the optical efficiency and detection sensitivity. It has potential applications for fast detection of dopamine in microsamples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Electrical & Electronic
Alberto Sinibaldi
Summary: This review discusses the development and application of photonic crystals-based biosensors for cancer biomarkers detection, highlighting the advantages of different structures of photonic crystals in the detection of cancer biomarkers and emphasizing their role in improving detection sensitivity.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Atsushi Miura, Riku Nohara, Azumi Nojima, Noboru Kitamura
Summary: This study reports the photothermal phase separation of aqueous PNIPAM/BuOH solutions using focused 1064 nm laser, resulting in the formation of single microparticles for the simultaneous extraction and detection of single RhB molecules. This method shows potential for micrometer-scale extraction and analysis of individual molecules in similar solutions.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Yu-Jia Wei, Ya-Nan Zhao, Xuan Zhang, Xing Wei, Ming-Li Chen, Xu-Wei Chen
Summary: Nowadays, biochemical analysis, such as cell analysis, disease diagnosis and treatment, environmental monitoring, and food safety, is receiving increasing attention. Optically integrated microfluidic technology combines the benefits of high sensitivity, fast detection, and excellent selectivity. By utilizing flexible optical detection techniques and precisely-controlled fluidics, microfluidic chips enable high throughput analysis, reduced reagent consumption, and decreased assay expenditure. This review introduces the integration of microfluidic chips with various optical detection techniques and their applications in biochemical analysis, and also discusses the future prospects of optically integrated microfluidic chips.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Thermodynamics
Hosung Byun, Hyungrok Do, Kyeongsun Kim, Kyungrae Kang, Juhyun Bae
Summary: A novel two-component seedless velocimetry utilizing shockwaves from laser-induced plasmas (LIP) is proposed. The velocimetry employs two pairs of continuous-wave (CW) laser beams and measures the flow velocity based on the arrival times of shockwaves on the probe beams. The measurement accuracy is 4-6 m/s for each velocity component, and a speed accuracy of 3 m/s is verified using hot-wire.
EXPERIMENTAL THERMAL AND FLUID SCIENCE
(2023)
Article
Biophysics
Shayan Valijam, Daniel P. G. Nilsson, Rasmus Oberg, Unni Lise, Albertsdottir Jonsmoen, Adrian Porch, Magnus Andersson, Dmitry Malyshev
Summary: In this study, a microfluidic lab-on-chip based on CPW was used to disrupt bacterial spores and release their biomarkers. Fluroescence spectroscopy and laser tweezers Raman spectroscopy were employed to detect the disruption of spores and the loss of calcium dipicolinic acid. Scanning electron microscopy also confirmed the visible disruption of spores after microwave exposure. This study demonstrates the advantages of using CPW for spore disruption and biomarker detection.
BIOSENSORS & BIOELECTRONICS
(2023)