Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies

Clinical presentation of PTEN mutations in childhood in the absence of family history of Cowden syndrome

(2015) T. Busa et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation

(2015) Yang Yang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The methylation of a panel of genes differentiates low-grade from high-grade gliomas

(2015) Aleksandra Majchrzak-Celińska et al.   TUMOR BIOLOGY

Variable Expression of PIK3R3 and PTEN in Ewing Sarcoma Impacts Oncogenic Phenotypes

(2015) Brian F. Niemeyer et al.   PLoS One

In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma

(2015) Maria Teresa Di Martino et al.   Oncotarget

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

(2015) Nicole M. Davis et al.   Oncotarget

Everolimus and zoledronic acid--a potential synergistic treatment for lung adenocarcinoma bone metastasis

(2014) Y. Yu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Roles of PTEN (Phosphatase and Tensin Homolog) in Gastric Cancer Development and Progression

(2014) Wen-Ting Xu et al.   Asian Pacific Journal of Cancer Prevention

miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

(2014) Yong Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy

(2014) Marieke L Kuijjer et al.   BMC Medical Genomics

Therapeutic Targeting of Cancers with Loss of PTEN Function

(2014) Lloye Dillon et al.   CURRENT DRUG TARGETS

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review

(2014) Gang Li et al.   Diagnostic Pathology

Bone-derived soluble factors and laminin-511 cooperate to promote migration, invasion and survival of bone-metastatic breast tumor cells

(2014) Delphine Denoyer et al.   GROWTH FACTORS

BYL719, a new α-specific PI3K inhibitor: Single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma

(2014) Bérengère Gobin et al.   INTERNATIONAL JOURNAL OF CANCER

High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor

(2014) Elke Joeckel et al.   Molecular Cancer

PTEN Deficiency Mediates a Reciprocal Response to IGFI and mTOR Inhibition

(2014) Mukund Patel et al.   MOLECULAR CANCER RESEARCH

MLN0128, an ATP-Competitive mTOR Kinase Inhibitor with Potent In Vitro and In Vivo Antitumor Activity, as Potential Therapy for Bone and Soft-Tissue Sarcoma

(2014) E. K. Slotkin et al.   MOLECULAR CANCER THERAPEUTICS

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Methylation analysis of the phosphates and tensin homologue on chromosome 10 gene (PTEN) in multiple myeloma

(2014) Giovanna Piras et al.   Clinical Epigenetics

Everolimus enhances the cytotoxicity of bendamustine in multiple myeloma cells through a network of pro-apoptotic and cell-cycle-progression regulatory proteins

(2013) B. Lu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells

(2013) Stephan Blüml et al.   ANNALS OF THE RHEUMATIC DISEASES

LY294002 Induces G0/G1 Cell Cycle Arrest and Apoptosis of Cancer Stem-like Cells from Human Osteosarcoma Via Down-regulation of PI3K Activity

(2013) Chen Gong et al.   Asian Pacific Journal of Cancer Prevention

PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy

(2013) Seth A. Wander et al.   BREAST CANCER RESEARCH AND TREATMENT

Bringing target-matched PI3King from the bench to the clinic

(2013) Filip Janku   CELL CYCLE

Targeting miR-21 Inhibits In Vitro and In Vivo Multiple Myeloma Cell Growth

(2013) E. Leone et al.   CLINICAL CANCER RESEARCH

High-resolution Genome-wide Copy-number Analyses Identify Localized Copy-number Alterations in Ewing Sarcoma

(2013) Miriam Lynn et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

The multiple layers of non-genetic regulation of PTEN tumour suppressor activity

(2013) Nádia C. Correia et al.   EUROPEAN JOURNAL OF CANCER

Wnt Pathway in Osteosarcoma, from Oncogenic to Therapeutic

(2013) Yu Cai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Celecoxib Inhibits β-Catenin-Dependent Survival of the Human Osteosarcoma MG-63 Cell Line

(2013) J-J Xia et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Rapamycin increases neuroblastoma xenograft and host stromal derived osteoprotegerin inhibiting osteolytic bone disease in a bone metastasis model

(2013) Joseph E. Hartwich et al.   JOURNAL OF PEDIATRIC SURGERY

PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling

(2013) M Conley-LaComb et al.   Molecular Cancer

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

MicroRNA-221 Induces Cell Survival and Cisplatin Resistance through PI3K/Akt Pathway in Human Osteosarcoma

(2013) Guangyi Zhao et al.   PLoS One

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN

(2013) Lei Shen et al.   TUMOR BIOLOGY

Perifosine Induces Cell Apoptosis in Human Osteosarcoma Cells: New Implication for Osteosarcoma Therapy?

(2012) Chen Yao et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome

(2012) S. Mueller et al.   NEURO-ONCOLOGY

Modulation of the Osteosarcoma Expression Phenotype by MicroRNAs

(2012) Heidi M. Namløs et al.   PLoS One

PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity

(2012) P. Tibarewal et al.   Science Signaling

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer

(2011) E. Razis et al.   BREAST CANCER RESEARCH AND TREATMENT

Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases

(2011) Osama Hussein et al.   CANCER LETTERS

Akt Induces Osteoclast Differentiation through Regulating the GSK3 /NFATc1 Signaling Cascade

(2011) J. B. Moon et al.   JOURNAL OF IMMUNOLOGY

Expression levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and focal adhesion kinase in patients with multiple myeloma and their relationship to clinical stage and extramedullary infiltration

(2011) Su-Yun Wang et al.   LEUKEMIA & LYMPHOMA

PI3K Pathway Mutations and PTEN Levels in Primary and Metastatic Breast Cancer

(2011) A. M. Gonzalez-Angulo et al.   MOLECULAR CANCER THERAPEUTICS

Correction: Bone metastasis in prostate cancer: emerging therapeutic strategies

(2011) Justin Sturge et al.   Nature Reviews Clinical Oncology

Testing of the Akt/PKB inhibitor MK-2206 by the pediatric preclinical testing program

(2011) Richard Gorlick et al.   PEDIATRIC BLOOD & CANCER

PTEN, PIK3CA, p-AKT, and p-p70S6K Status

(2010) Francisco J. Esteva et al.   AMERICAN JOURNAL OF PATHOLOGY

Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP

(2010) Seaho Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma

(2010) Suyun Wang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Is PTEN loss associated with clinical outcome measures in human prostate cancer?

(2008) P McCall et al.   BRITISH JOURNAL OF CANCER

Copy number gains inEGFRand copy number losses inPTENare common events in osteosarcoma tumors

(2008) Serena S. Freeman et al.   CANCER

Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment

(2008) A. Huston et al.   CLINICAL CANCER RESEARCH

Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome

(2008) M S Orloff et al.   ONCOGENE

Celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt

(2007) B LIU et al.   CELL BIOLOGY INTERNATIONAL