Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The present study demonstrated that miR-1297 inhibited proliferation and tumor growth in osteosarcoma by directly targeting CCND2.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The study revealed that miR-1297 can inhibit proliferation and tumor growth in osteosarcoma by directly targeting CCND2. Overexpression of miR-1297 significantly suppressed CCND2 protein expression and resulted in similar phenotypic effects as CCND2 downregulation. Therefore, miR-1297 may represent a novel therapeutic target for osteosarcoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Maoshu Zhu, Yulong Wu, Zhaowei Wang, Minghua Lin, Bin Su, Chunyang Li, Fulong Liang, Xinjiang Chen
Summary: The study found that miR-128-3p can directly target ZC3H12D, downregulating its expression and promoting cell proliferation and migration. Overexpression of miR-128-3p also increased resistance to cisplatin in MG-63 and 143B cell lines, suggesting its potential role as an oncogene in osteosarcoma cells.
Article
Biochemistry & Molecular Biology
Yize Liu, Guanzhen Qiu, Yinzhou Luo, Shanshan Li, Yeqiu Xu, Yuanzhuang Zhang, Jiayuan Hu, Peifeng Li, Hai Pan, Yong Wang
Summary: This study investigated a circular RNA called circROCK1-E3/E4 in osteosarcoma (OS) and found that it functions as a tumor suppressor by upregulating PTEN. The downregulation of circROCK1-E3/E4 is correlated with poor prognosis, suggesting its potential as a therapeutic target for OS.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Fei Han, Peidong Pu, Chao Wang, Xiao Ding, Zhoujun Zhu, Wei Xiang, Weishan Wang
Summary: The study demonstrates that OS cell-derived exosomal miR-1307 promotes the proliferation, migration, and invasion of OS cells by targeting AGAP1. The miR-1307-AGAP1 axis may play a significant role in the future treatment of OS.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Cell Biology
Gang Han, Quanyi Guo, Ning Ma, Wenzhi Bi, Meng Xu, Jinpeng Jia
Summary: Apatinib inhibits the proliferation and migration of osteosarcoma cells through the LINC00261/miR-620/PTEN axis, indicating its potential therapeutic efficacy.
Article
Immunology
Jin-ya Wang, Xiaoyan Dong, Zhiwei Yu, Lei Ge, Lu Lu, Ling Ding, Weihua Gan
Summary: The study demonstrated that borneol alleviated asthma in mice by downregulating miR-26a and miR-142-3p, which reduced CD4+ T cells infiltration, thereby attenuating disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Wei Liu, Dunwei Wang, Lidi Liu, Lin Wang, Ming Yan
Summary: The study revealed the important role of miR-140 in osteosarcoma development, inhibiting tumor cell proliferation, migration, and invasion, as well as promoting cell apoptosis by targeting USP22.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Neurosciences
Huiqing Hou, Yafei Wang, Lan Yang, Yongjun Wang
Summary: This study demonstrates that fibrinogen deposition inhibits remyelination after ischemic stroke by activating ACVR1 and suppressing OPC differentiation. It also reveals that NSC-derived exosomal miR-128-3p promotes OPC differentiation into OLs by inhibiting BMP signaling. These findings suggest that NSC-derived exosomal miR-128-3p may serve as a potential therapeutic target for ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medical Laboratory Technology
Lina Wu, Xinpeng Zhang, Lin Luo, Xiaoying Li, Yong Liu, Xiaosong Qin
Summary: The study found that miR-106a, miR-19b, miR-17, and PTEN are involved in the pathogenesis of IMN and may serve as new biomarkers for the diagnosis of IMN.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Xiaobo Peng, Chengtao Guo, Yanjun Wu, Mingzhen Ying, Renxu Chang, Lele Song, Lixing Zhan, Xianbao Zhan
Summary: Pancreatic mucinous cystadenocarcinoma (MCC) is a rare malignant tumor with limited research. This study found that miR-224-5p is highly expressed in MCC and plays an oncogenic role in promoting proliferation, migration, and invasion of these tumor cells. PTEN was identified as a direct target gene of miR-224-5p, with a negative correlation between the two observed both in vitro and in vivo.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Wen-Kang Chen, Han-Jing Zhang, Ming-Xiang Zou, Cheng Wang, Yi-Guo Yan, Xin-Li Zhan, Xue-Lin Li, Wen-Jun Wang
Summary: In this study, the function of lncRNA HOTAIR in the proliferation of human nucleus pulposus (NP) cells of intervertebral disc degeneration (IDD) was investigated. The results showed that HOTAIR can suppress proliferation by directly targeting miR-130b. Additionally, HOTAIR upregulation significantly reduced CyclinD1 protein expression through the PTEN/AKT signaling pathway. These findings suggest that HOTAIR may be a potential target for the treatment of IDD.
Article
Biochemistry & Molecular Biology
Hiroki Yoshioka, Goo Jun, Akiko Suzuki, Junichi Iwata
Summary: The study identified novel pathogenic microRNAs associated with cleft palate. miR-449 and miR-486b promote cell proliferation, while miR-130a and miR-301a inhibit it. Dexamethasone suppresses miR-130a expression, and a miR-130a mimic can ameliorate the cell proliferation defect induced by dexamethasone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hui Zhao, Yongping Wang, Weihua Hou, Xuanxi Ding, Wenji Wang
Summary: In osteosarcoma, lncRNA MALAT1 was found to promote cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) while inhibiting apoptosis by suppressing miR-590-3p. These findings highlight the important role of MALAT1 in osteosarcoma and its potential value in diagnosis and treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Rongrong Yan, Shuangfen Jin, Hongchao Liu, Chengjin Le, Jie Gao, Jing Cheng, Lin Chen, Na Li
Summary: The study demonstrated that Dexmedetomidine inhibits the malignancy of osteosarcoma cells by upregulating miR-520a-3p to suppress YOD1 expression, suggesting a new potential therapeutic approach for osteosarcoma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Physics, Applied
Taotao Li, Shijie Ma, Shixin Feng, Ruxin Ren, Li Zhang, Huihu Lu, Guoping Li, Yaohui Zhang, Wei Fan, Chengzhi Liu, Diaoyu Zhou
Summary: In this study, electrolysis was used to distinguish 2205 duplex steel samples with different corrosion performance. X-ray diffraction, scanning electron microscopy, and electron backscattering diffraction were employed to characterize the microstructure and corrosion behavior of regions with superior and inferior corrosion performance.
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
(2022)
Article
Chemistry, Physical
Xing Yue, Xiqiang Huang, Jingwei Li, Chaoxiang Su, Yaxin Zhang, Yaohui Zhang, Bo Wei, Zhe Lv
Summary: In this study, the surface morphology of CCO cathode was reconstructed through a reduction and re-oxidation process, leading to significant improvement in cathode performance. The ORR activity of the CCO cathode was notably enhanced after the treatment, which was attributed to the increased specific surface area and enhanced oxygen adsorption ability.
JOURNAL OF POWER SOURCES
(2022)
Article
Chemistry, Physical
Yabin Shen, Xiaojing Yao, Jianhua Zhang, Shaohua Wang, Dongyu Zhang, Dongming Yin, Limin Wang, Yaohui Zhang, Junhua Hu, Yong Cheng, Xifei Li
Summary: Na-doped high-nickel low-cobalt cathode materials can greatly improve the lithium storage performance and cycle life, as well as enhance the electrode-electrolyte interface and thermal stability.
Review
Surgery
Liang Hu, Yijun Wu, Fangyu Ju, Yaohui Zhang, Weilin Wang
Summary: This study reevaluated the risk of developing thyroid cancer (TC) after solid organ transplantation (SOT) based on the latest literature. The results showed that patients undergoing different solid organ transplantations, especially kidney transplantation, had an increased risk of developing TC. Therefore, aggressive and regular tumor screenings after SOT may improve patient prognosis.
Article
Respiratory System
Hongxia Ma, Qian Zhang, Yanwen Zhao, Yaohui Zhang, Jingjing Zhang, Guoqing Chen, Yuan Tan, Qin Zhang, Qianqian Duan, Tingting Sun, Chuang Qi, Fengsen Li
Summary: This study collected and analyzed clinicopathological and genomic data of lung cancer patients with and without COPD. The results showed that COPD patients had higher mutation frequency and tumor immunity, indicating potential benefits from immunotherapy.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Mechanics
Menglong Liu, Lun Li, Yaohui Zhang, Gongfa Chen, Fangsen Cui
Summary: This study proposes a novel Gauss-Lobatto-Legendre-based high-order semi-analytical finite element method (GLL-SAFE) to accurately calculate the dispersive natures of guided waves in complex waveguides. Through the combination of GLL node collation and Lobatto quadrature, GLL-SAFE shows faster solution speed and reduced matrix inversion error. The results demonstrate smaller average relative errors and higher calculation efficiency compared to the conventional Gauss-SAFE.
INTERNATIONAL JOURNAL OF APPLIED MECHANICS
(2022)
Retraction
Orthopedics
Xinwen Zhao, Wensen Jing, Zhe Yun, Xun Tong, Zhao Li, Jiajia Yu, Yaohui Zhang, Yabin Zhang, Zhixue Wang, Yanhua Wen, Heping Cai, Jun Wang, Baoan Ma, Haien Zhao
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Surgery
Liang Hu, Yijun Wu, Fangyu Ju, Yaohui Zhang, Weilin Wang
Summary: This study compared the clinicopathological features of papillary thyroid carcinoma (PTC) between solid organ transplant recipients (SOTR) and the general population, and found that PTC in SOTR demonstrated a more malignant pathological feature.
Article
Engineering, Environmental
Kai Wang, Jiangchun Chen, Fengxiao Hou, Han Wang, Yaohui Zhang, Xiaobin Zhong, Yuexian Song, Yangang Zhang, Zhiwen Zhang, Hantao Liu, Junfei Liang, Hua Wang
Summary: The transport capacity of lithium ions in metal organic frameworks (MOFs) is improved by optimizing the pore structure and enhancing electronic conductivity through the growth of Al-MOF particles on reduced graphene oxide (RGO) layer. The optimized Al-MOF@RGO anode exhibits high specific capacity after 1000 cycles, indicating its potential for commercial applications in lithium-ion batteries (LIBs).
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Kai Wang, Jianming Sun, Haoqing Yang, Yaohui Zhang, Xiaobin Zhong, Yuexian Song, Fengxiao Hou, Yangang Zhang, Zhiwen Zhang, Han Wang, Jian Zhu, Hongtao Sun, Junfei Liang
Summary: A 3D interconnected amorphous carbon nanowire network with developed hierarchical pores was prepared from sub-micron brick-like crystal Al-MOF through rapid heat and linker removal processes. The 3D amorphous carbon electrode exhibited superior rate performance and delivered a capacity as high as 400 mAh/g under a current density of 1.0 A/g, even after 1000 cycles, with an ultra-high capacity retention rate of 101.8%. This method represents a critical step toward realizing the full potential of MOF-derived carbon electrode materials in practical LIBs applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Chemistry, Physical
Menglong Liu, Yaohui Zhang, Lun Li, Gongfa Chen, Fangsen Cui
Summary: The study proposes using a genetic algorithm to reconstruct the stiffness matrix of carbon fiber reinforced polymer and validates the method's effectiveness experimentally, achieving high accuracy for the parameters measured in CFRPs with different stacking sequences.
Article
Environmental Sciences
Dong Guo, Hantao Liu, Yaohui Zhang, Yingchun Wang, Yaxuan Xiong
Summary: Researchers have successfully developed a form-stable phase change material using semi-coke ash as the skeleton material and solar salt as the phase change material. The sample A55, with a 50 wt% solar salt content, exhibited the best performance, with a thermal energy storage density of 483 J/g in the temperature range of 100 to 450 degrees Celsius. The A55 sample also showed excellent compressive strength, reaching 86.12 MPa, as well as good chemical compatibility and thermal stability.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Engineering, Electrical & Electronic
Jian Yang, Xun Liu, Xiaofeng Jiang, Yaohui Zhang, Shuangwu Chen, Huasen He
Summary: To enhance internal security of UAV swarm, a blockchain-based UAV trusted self-organizing networking mechanism (BC-UTSON) was developed. This mechanism utilizes three key technologies including UAV practical Byzantine fault tolerance (U-PBFT), blockchain-based multiweighted subjective logic (BMWSL) scheme, and trusted path quality-aware dynamic routing (TPDR) mechanism. Experimental results show that BC-UTSON performs better than nonblockchain-based mechanisms in UAV swarm.
IEEE VEHICULAR TECHNOLOGY MAGAZINE
(2023)
Review
Chemistry, Multidisciplinary
Yitao He, Yujie Dong, Yaohui Zhang, Yongtao Li, Haijin Li
Summary: The intercalation of anions into cost-effective graphite electrode provides a high operating voltage, making dual-ion batteries (DIBs) a promising energy storage device. The graphene in graphite, which has rarely been researched, can utilize its ultra-high elastic stiffness and reversible lattice expansion to increase the storage capacity of anions. This review proposes a blister model using high elasticity of graphene blisters and their possible formation mechanism, suggesting their significance in the development of cathode materials for DIBs.
Article
Chemistry, Physical
Yue-Xian Song, Jiao Wang, Xiao-Bin Zhong, Kai Wang, Yao-Hui Zhang, Han-Tao Liu, Li-Xin Zhang, Jun-Fei Liang, Rui Wen
Summary: This study presents a novel additive design principle to enhance the reversible and dendrite-free zinc anode in aqueous batteries. By introducing Dibenzene-sulfonamide (BBI) into ZnSO4 electrolyte, BBI-derivate is preferentially chemisorbed on Zn surface to protect against corrosion and suppress hydroxide sulfate formation. Furthermore, the decomposition of BBI leads to the in-situ construction of a robust organic-inorganic hybrid solid electrolyte interphase on Zn anode, which regulates the Zn-anode interfacial chemistry to enable uniform Zn deposition. Consequently, the Zn symmetric cells exhibit prolonged cycling lifespan and high capacity. This study provides insights into the additive regulation mechanisms and offers a promising approach to solve the anode nuisance in aqueous metal batteries.
ENERGY STORAGE MATERIALS
(2023)
