Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes

Cell death in human articular chondrocyte: a morpho-functional study in micromass model

(2014) M. Battistelli et al.   APOPTOSIS

Disruption of Phosphoinositide-Specific Phospholipases Cγ1 Contributes to Extracellular Matrix Synthesis of Human Osteoarthritis Chondrocytes

(2014) Guoqing Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation

(2013) Hui-ming Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritisviaAkt signalling

(2013) Honghai Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes

(2012) Yosuke Hattori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis

(2012) Xinpeng Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes

(2012) Qingzhi Chen et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)

(2011) Malik M. Keshwani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin

(2011) S.C. Rosa et al.   OSTEOARTHRITIS AND CARTILAGE

Neuroprotective effect of morroniside on focal cerebral ischemia in rats

(2010) Wen Wang et al.   BRAIN RESEARCH BULLETIN

Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes

(2010) Frank Beier et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Roles of Ets-1 and p70S6 kinase in chondrogenic and gliogenic specification of mouse mesencephalic neural crest cells

(2010) Keisuke Sugiura et al.   MECHANISMS OF DEVELOPMENT

Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells

(2010) Mansoor Ahmed et al.   Molecular Cancer

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Basic methods in histopathology of joint tissues

(2010) N. Schmitz et al.   OSTEOARTHRITIS AND CARTILAGE

Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis

(2009) John D. Cravero et al.   ARTHRITIS AND RHEUMATISM

The Beneficial Effects of Morroniside on the Inflammatory Response and Lipid Metabolism in the Liver of db/db Mice

(2009) Chan Hum Park et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity

(2009) Wen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanism of PDK1-catalyzed Thr-229 Phosphorylation of the S6K1 Protein Kinase

(2009) Malik M. Keshwani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress Inhibits Insulin-like Growth Factor-I Induction of Chondrocyte Proteoglycan Synthesis through Differential Regulation of Phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK Signaling Pathways

(2009) Weihong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

(2009) G. Distefano et al.   MOLECULAR AND CELLULAR BIOLOGY

Cilostazol protects rat chondrocytes against nitric oxide–induced apoptosis in vitro and prevents cartilage destruction in a rat model of osteoarthritis

(2008) Sung Won Lee et al.   ARTHRITIS AND RHEUMATISM

IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways

(2008) M. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE