Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways

Gastrointestinal Factors Influencing Zinc Absorption and Homeostasis

(2013) Robert J. Cousins   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation

(2012) S McComb et al.   CELL DEATH AND DIFFERENTIATION

Pathogenesis of severe asthma

(2012) A. H. Poon et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Dynamic role of epithelium-derived cytokines in asthma

(2012) Kathleen R. Bartemes et al.   CLINICAL IMMUNOLOGY

Virus infection and allergy in the development of asthma

(2012) Patrick G. Holt et al.   Current Opinion in Allergy and Clinical Immunology

Emerging drugs for asthma

(2012) Santiago Quirce et al.   EXPERT OPINION ON EMERGING DRUGS

Implication of BIRC5 in asthma pathogenesis

(2012) I. Ungvari et al.   INTERNATIONAL IMMUNOLOGY

Calcium upregulated survivin expression and associated osteogenesis of normal human osteoblasts

(2012) Jan Ortiz et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Novel Polypyridyl chelators deplete cellular zinc and destabilize the X-linked inhibitor of apoptosis protein (XIAP) prior to induction of apoptosis in human prostate and breast cancer cells

(2012) Jian Zuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Discovery of human zinc deficiency: 50 years later

(2012) Ananda S. Prasad   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Innate and adaptive immune responses in asthma

(2012) Stephen T Holgate   NATURE MEDICINE

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

Mechanism of zinc-mediated inhibition of caspase-9

(2012) Kristen L. Huber et al.   PROTEIN SCIENCE

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

Trials and tribulations in identifying new biologic treatments for asthma

(2012) Stephen T. Holgate   TRENDS IN IMMUNOLOGY

Modulation of immune signalling by inhibitors of apoptosis

(2012) Shawn T. Beug et al.   TRENDS IN IMMUNOLOGY

Zinc and Regulation of Inflammatory Cytokines: Implications for Cardiometabolic Disease

(2012) Meika Foster et al.   Nutrients

Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP

(2011) Sarvenaz Karimpour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats

(2011) Lana J Mawhinney et al.   BMC NEUROSCIENCE

IAPS : More than just inhibitors of apoptosis proteins

(2011) Laurence Dubrez-Daloz et al.   CELL CYCLE

IAPs: Guardians of RIPK1

(2011) M Darding et al.   CELL DEATH AND DIFFERENTIATION

Fas death receptor signalling: roles of Bid and XIAP

(2011) T Kaufmann et al.   CELL DEATH AND DIFFERENTIATION

Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome

(2011) Katherine Labbé et al.   IMMUNITY

Defective function at the epithelial junction: A novel therapeutic frontier in asthma?

(2011) Darryl A. Knight et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective epithelial barrier function in asthma

(2011) Chang Xiao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epithelial Apoptosis and Loss in Airways of Children with Asthma

(2011) Chunju Zhou et al.   JOURNAL OF ASTHMA

CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration

(2011) Juanita Lopez et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

Sputum zinc concentration and clinical outcome in older asthmatics

(2011) LATA JAYARAM et al.   RESPIROLOGY

Ripoptosome: a novel IAP-regulated cell death-signalling platform

(2011) G. Imre et al.   Journal of Molecular Cell Biology

Apical Localization of Zinc Transporter ZnT4 in Human Airway Epithelial Cells and Its Loss in a Murine Model of Allergic Airway Inflammation

(2011) Chiara Murgia et al.   Nutrients

Survivin and IAP proteins in cell-death mechanisms

(2010) Dario C. Altieri   BIOCHEMICAL JOURNAL

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)

(2010) Peter Goettig et al.   BIOCHIMIE

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Recent Advances in the Pathophysiology of Asthma

(2010) Desmond M. Murphy et al.   CHEST

Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9

(2010) Jamshid Davoodi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

cIAP1 Cooperatively Inhibits Procaspase-3 Activation by the Caspase-9 Apoptosome

(2010) Stephen P. Burke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Virus-triggered Ubiquitination of TRAF3/6 by cIAP1/2 Is Essential for Induction of Interferon-β (IFN-β) and Cellular Antiviral Response

(2010) Ai-Ping Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asymmetric Recruitment of cIAPs by TRAF2

(2010) Peter D. Mace et al.   JOURNAL OF MOLECULAR BIOLOGY

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

(2010) Christopher D Gregory et al.   JOURNAL OF PATHOLOGY

Regulation of the Copper Chaperone CCS by XIAP-Mediated Ubiquitination

(2010) G. F. Brady et al.   MOLECULAR AND CELLULAR BIOLOGY

X-Linked Inhibitor of Apoptosis Protein Inhibits Apoptosis in Inflammatory Breast Cancer Cells with Acquired Resistance to an ErbB1/2 Tyrosine Kinase Inhibitor

(2010) K. M. Aird et al.   MOLECULAR CANCER THERAPEUTICS

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Survivin mediates prostate cell protection by HIF-1α against zinc toxicity

(2010) Young-Joo Yun et al.   PROSTATE

Apoptosis-Regulatory Factors as Potential Drug Targets in the Epithelium of Normal and Inflamed Airways

(2010) P. Zalewski et al.   Current Molecular Pharmacology

Structures of BIR domains from human NAIP and cIAP2

(2009) Maria Dolores Herman et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Animal models of asthma

(2009) Jason H. T. Bates et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mammalian Zinc Transporters: Nutritional and Physiologic Regulation

(2009) Louis A. Lichten et al.   Annual Review of Nutrition

The 423Q polymorphism of the X-linked inhibitor of apoptosis gene influences monocyte function and is associated with periodic fever

(2009) Massimo Ferretti et al.   ARTHRITIS AND RHEUMATISM

XIAP as a ubiquitin ligase in cellular signaling

(2009) S Galbán et al.   CELL DEATH AND DIFFERENTIATION

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

(2009) A Weber et al.   CELL DEATH AND DIFFERENTIATION

International Trends in Asthma Mortality Rates in the 5- to 34-Year Age Group

(2009) Meme Wijesinghe et al.   CHEST

Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma

(2009) Damon J. Tumes et al.   INTERNATIONAL IMMUNOLOGY

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

(2009) James E. Vince et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Cytoprotective Effects of the Inhibitor of Apoptosis Protein Cellular IAP1 through Stabilization with TRAF2

(2009) Rebecca A. Csomos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing

(2009) Young Eun Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

The emerging roles of serine protease cascades in the epidermis

(2009) Petra Ovaere et al.   TRENDS IN BIOCHEMICAL SCIENCES

COMMD1 expression is controlled by critical residues that determine XIAP binding

(2008) Gabriel N. Maine et al.   BIOCHEMICAL JOURNAL

Inhibitors of apoptosis catch ubiquitin: Figure 1

(2008) Krishnaraj Rajalingam et al.   BIOCHEMICAL JOURNAL

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21

(2008) John W. Blankenship et al.   BIOCHEMICAL JOURNAL

Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung

(2008) Chris Planque et al.   BIOLOGICAL CHEMISTRY

Final Stages of Cytokinesis and Midbody Ring Formation Are Controlled by BRUCE

(2008) Christian Pohl et al.   CELL

Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis

(2008) P Makhov et al.   CELL DEATH AND DIFFERENTIATION

Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment

(2008) Peter D. Mace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

IAPs: What's in a Name?

(2008) Srinivasa M. Srinivasula et al.   MOLECULAR CELL

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

(2008) Mads Gyrd-Hansen et al.   NATURE CELL BIOLOGY

The Airway Epithelium is Central to the Pathogenesis of Asthma

(2008) Stephen T. Holgate   ALLERGOLOGY INTERNATIONAL