Journal
JOURNAL OF CELL SCIENCE
Volume 128, Issue 5, Pages 900-912Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.157974
Keywords
Collective migration; glial cells; N-cadherin; actin cytoskeleton; Drosophila
Categories
Funding
- INSERM grant
- CNRS grant
- UDS grant
- Hopital de Strasbourg grant
- ARC grant
- INCA grant
- Indo-French Center for the Promotion of Advanced Research (CEFIPRA) grant
- ANR grant
- AFM fellowship
- ARC fellowship
- CEFIPRA fellowship
- French state fund through the ANR labex
- Company of Biologist
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Cell migration is an essential and highly regulated process. During development, glia cells and neurons migrate over long distances in most cases collectively - to reach their final destination and build the sophisticated architecture of the nervous system, the most complex tissue of the body. Collective migration is highly stereotyped and efficient, defects in the process leading to severe human diseases that include mental retardation. This dynamic process entails extensive cell communication and coordination, hence, the real challenge is to analyze it in the entire organism and at cellular resolution. We here investigate the impact of the N-cadherin adhesion molecule on collective glial migration, by using the Drosophila developing wing and cell-type specific manipulation of gene expression. We show that N-cadherin timely accumulates in glial cells and that its levels affect migration efficiency. N-cadherin works as a molecular brake in a dosage-dependent manner, by negatively controlling actin nucleation and cytoskeleton remodeling through alpha/beta catenins. This is the first in vivo evidence for N-cadherin negatively and cell autonomously controlling collective migration.
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