Article
Cell Biology
Rui Sun, Lixiazi He, Hyeyoon Lee, Andrey Glinka, Carolin Andresen, Daniel Huebschmann, Irmela Jeremias, Karin Mueller-Decker, Caroline Pabst, Christof Niehrs
Summary: RSPO2 promotes self-renewal of AML cells and may serve as a marker for poor prognosis. It maintains AML self-renewal independently of WNT by inhibiting BMP receptor signaling.
Article
Multidisciplinary Sciences
Marco Ronzani, Simon Woyke, Norbert Mair, Hannes Gatterer, Herbert Oberacher, David Plunser, Thomas Haller, Mathias Stroehle, Christopher Rugg
Summary: Desflurane, isoflurane, and sevoflurane, three commonly used inhaled anesthetics, have varying effects on hemoglobin-oxygen affinity at different doses, but the underlying mechanisms are unclear.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Joep Sprangers, Irene C. Zaalberg, Madelon M. Maurice
Summary: This review discusses the regenerative response of intestinal epithelial cells to injury, as well as how the Wnt and YAP signaling pathways control intestinal repair. It also emphasizes how organoid-based applications have contributed to unraveling the key mechanisms behind these developmental and regenerative events.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Multidisciplinary Sciences
German Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Summary: RNF43/ZNRF3 alterations contribute to liver disease and liver cancer by affecting differentiation and lipid metabolism of hepatocytes. The loss of these genes leads to steatohepatitis and an increase in unsaturated lipids. Deletion of Rnf43/Znrf3 results in defective hepatocyte regeneration and liver cancer, causing an imbalance between differentiation and proliferation. Interestingly, ZNRF3 mutant liver cancer patients have a poorer prognosis and exhibit altered hepatic lipid metabolism and steatohepatitis/NASH signatures.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Hui Cheng, Qinfang Li
Summary: This study found that sevoflurane induces apoptosis and inhibits the growth, migration, and invasion of cholangiocarcinoma cells by inhibiting the Wnt/beta-catenin signaling pathway. It not only reveals the role of sevoflurane in the development of CCA but also elucidates new therapeutic agents for CCA.
BMC GASTROENTEROLOGY
(2023)
Article
Agriculture, Multidisciplinary
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui, Shaoping Nie
Summary: The study revealed that glucomannan from Aloe vera gel promoted proliferation and differentiation of intestinal stem cells through the Wnt/β-catenin signaling pathway, facilitating epithelial cell regeneration and alleviating colitis in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Naoki Asano, Akio Takeuchi, Akira Imatani, Masashi Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune
Summary: In an aging society, it is crucial to study the role of Wnt signaling in aging of the gastrointestinal tract and aging-related carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huacheng Luo, Ganqian Zhu, Melanie A. Eshelman, Tsz Kan Fung, Qian Lai, Fei Wang, Bernd B. Zeisig, Julia Lesperance, Xiaoyan Ma, Shi Chen, Nicholas Cesari, Christopher Cogle, Baoan Chen, Bing Xu, Feng-Chun Yang, Chi Wai Eric So, Yi Qiu, Mingjiang Xu, Suming Huang
Summary: In acute myeloid leukemia (AML), HOTTIP lncRNA is highly expressed and drives AML development by regulating the formation of HOXA topologically associated domains (TADs) and aberrant transcription. This study reveals that HOTTIP directly interacts with a fraction of CTCF-binding sites (CBSs) in the AML genome and recruits CTCF/cohesin complex and R-loop-associated regulators to form R-loops. HOTTIP-mediated R-loop formation reinforces CTCF chromatin boundary activity and facilitates TAD formation, driving oncogene transcription and leukemia development.
Article
Cell & Tissue Engineering
Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang, Limin Rong
Summary: The study demonstrates that melatonin enhances the hypertrophic differentiation of MSC-derived chondrocytes through the Wnt signaling pathway, increasing chondrocyte cell volume and type X collagen expression while decreasing type II collagen expression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Koichi Yuki, Yusuke Mitsui, Miho Shibamura-Fujiogi, Lifei Hou, Kirsten C. Odegard, Sulpicio G. Soriano, Gregory P. Priebe, Sophia Koutsogiannaki
Summary: Isoflurane and sevoflurane, commonly used volatile anesthetics, show immunomodulatory effects and may impact disease progression by attenuating lung injury and inhibiting TLR5 activation. Studies suggest they have a protective effect on gas exchange in patients with cystic fibrosis. Additionally, docking simulations indicate these anesthetics interact with TLR5 and flagellin for potential therapeutic benefits.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Laura Jansen, Bente F. H. Dubois, Markus W. Hollmann
Summary: Every year, millions of patients are diagnosed with cancer and undergo surgical resection with anesthesia. However, a significant number of these patients experience recurrence or metastasis after surgery. The effect of different anesthesia techniques on postoperative outcomes in oncological surgery is still controversial and lacks substantial evidence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lingchen Fu, Jia Fan, Sudipa Maity, Grant McFadden, Yixin Shi, Wei Kong
Summary: PD-L1 interacts with Frizzled 6 receptor to activate beta-catenin signaling and increase the expression of stem cell markers, thereby maintaining and expanding the population of cancer stem cells. Blocking PD-L1 function can inhibit tumor progression by reducing the CSC population.
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)