Article
Multidisciplinary Sciences
Maria del Mar Aguilo-Ferretjans, Rafael Bosch, Richard J. Puxty, Mira Latva, Vinko Zadjelovic, Audam Chhun, Despoina Sousoni, Marco Polin, David J. Scanlan, Joseph A. Christie-Oleza
Summary: The study reveals that one in four picocyanobacteria encode a type IV pilus, allowing them to maintain optimal positions in the water column, while also evading predation.
NATURE COMMUNICATIONS
(2021)
Article
Robotics
Michael F. Reynolds, Alejandro J. Cortese, Qingkun Liu, Zhangqi Zheng, Wei Wang, Samantha L. Norris, Sunwoo Lee, Marc Z. Miskin, Alyosha C. Molnar, Itai Cohen, Paul L. McEuen
Summary: This study develops an integration process and builds microscopic robots controlled by complementary metal oxide semiconductor electronics. These robots, sized from 100 to 250 micrometers, are powered by light and can respond to optical commands. This work lays the foundation for the development of future autonomous microscopic robots.
Review
Pharmacology & Pharmacy
Qingyao Liu, Yongkang Gai, Yaqi Chen, Xiaoli Lan, Dawei Jiang
Summary: Escherichia coli Nissle 1917 (EcN) demonstrates promising potential as a drug delivery system for tumor treatment due to its facultative anaerobic property that allows it to selectively colonize in the hypoxic area of tumors. By engineering EcN as a bacteria-based microrobot, it can be utilized for molecular imaging, drug delivery, and gene delivery in cancer therapy.
Article
Multidisciplinary Sciences
Louis S. Prahl, Catherine M. Porter, Jiageng Liu, John M. Viola, Alex J. Hughes
Summary: Tissue boundaries and interfaces play a crucial role in morphogenesis in vivo. However, controlling cell positioning within tissue constructs is still a challenge in tissue engineering. This study presents a new approach that combines DNA velcro patterning and ECM functionalization to achieve precise control of cell placement, adhesion, and mechanics in engineered tissues.
Review
Engineering, Multidisciplinary
Min Wang, Tianyi Wu, Rui Liu, Zhuoran Zhang, Jun Liu
Summary: This paper reviews recent advances in selective and independent control for multi-microrobot or multi-joint microrobot systems driven by magnetic fields. It introduces methods to decode global magnetic fields for individualized actuation of multiple microrobots and emphasizes the importance of independent control for the effective cooperation of multiple microrobots in accomplishing complex operations.
Article
Mechanics
Zeeshan Asghar, Ahmed Elmoasry, Wasfi Shatanawi, Muhammad Asif Gondal
Summary: The study investigates the dynamic role of marine microbes in the aquatic ecosystem and explores the fluid mechanics of gliding organisms near a porous boundary. The effects of surface roughness on the lower substrate are considered, and a non-Newtonian Jeffrey fluid is used to represent the ooze layer between micro-swimmers and the rough substrate. The laminar flow of incompressible slime generated by organism movement is analyzed using Darcy's law and lubrication assumption.
Article
Biochemical Research Methods
Ting Lu, Congjian Ni
Summary: This study presents an individual-based, biophysical computational framework for simulating the spatiotemporal dynamics of microbial populations. The framework successfully validates single-cell chemotaxis simulations and reveals spatial patterns of different microbial populations. This study provides insights into microbial spatial ecology and offers a tool for designing spatial patterns in synthetic biology.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sankalpa Venkatraghavan, Sathvik Anantakrishnan, Karthik Raman
Summary: Microbial consortia exhibit spatiotemporal organization through bacterial communication. Simulations show that secretion rates play a key role in controlling the behavior of the coupled consortia. These models provide a simplified and controllable approach to pattern formation in synthetic biology.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Mechanical
Yuanyi Wang, Biao Wang, Yanhu Zhang, Lei Wei, Chai Yu, Zuankai Wang, Zhengbao Yang
Summary: Inspired by the structure of T-phage, the T-phage Mimic MicroRobot (TMMR) mimics the core and tail of the T-phage, demonstrating high robustness, low voltage driving, and versatile locomotive strategies. The triangular prism structure enables stable movement and provides a large carrying capacity.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Cornel Dillinger, Justin Knipper, Nitesh Nama, Daniel Ahmed
Summary: The manipulation of soft polymeric microrobots in aquatic environments is challenging, but wireless manipulation can be achieved using external field-guided technologies. This study presents the fabrication and manipulation of a magnetized soft polymeric microrobot, which achieves stable manipulation through acoustic propulsion and magnetic field-guided navigation.
Article
Microbiology
Sijia Liu, Zhongtang Yu, Huiyue Zhong, Nan Zheng, Sharon Huws, Jiaqi Wang, Shengguo Zhao
Summary: This study established an integrated approach to isolate ureolytic bacteria from the rumen microbiome. Genomic analyses revealed that these newly isolated bacteria represent the most abundant ureolytic species ever identified. These ureolytic bacteria have significant impacts on urea metabolism and milk protein production in the rumen, and key amino acid residues for urease activation were identified. This methodology provides a valuable resource for studying ruminal bacteria and bridges the gap between genotypes and phenotypes of uncultured bacteria.
Article
Engineering, Electrical & Electronic
Wenhao Wang, Yingzheng He, Huibin Liu, Qinghao Guo, Zhixing Ge, Wenguang Yang
Summary: Microbubbles have become increasingly popular in microfluidic chips due to their biocompatibility, easy manipulation, and convenient manufacture. They can be regarded as robotic tools that operate on micro-scale objects. This review discusses the different methods of manufacturing bubbles, their properties and morphology, as well as their applications as photothermal bubble microrobots, acoustic oscillation bubble microrobots, and Janus bubble micromotors. It also analyzes the movement mechanisms and particle manipulation capabilities of these microbubbles and highlights their potential future developments.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Microbiology
Victoria Palma, Maria Soledad Gutierrez, Orlando Vargas, Raghuveer Parthasarathy, Paola Navarrete
Summary: Bacterial motility is a common characteristic that can be studied through various methods, with three-dimensional imaging being advantageous in microscopic approaches. Understanding bacterial motility is also important for studying bacterial-host interactions.
Article
Biotechnology & Applied Microbiology
Dinesh Labade, Heena Tabassum, Minal Wani
Summary: Distinct bacterial isolates capable of breaking down agar were found in various nonmarine environments according to our investigation. The agar in the experiment was broken down by bacteria to produce various oligosaccharides, as confirmed by the deficiency of reducing sugar in the control media and the change in viscosity. Gram-negative bacteria were found to be the main cause of agar deterioration. The agarase secreted by these bacteria impacted the gel characteristics, as observed from the detection of extracellular agarase and the absence of stained halos.
LETTERS IN APPLIED MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yiyu Zhang, Da Wei, Xiaochen Wang, Boyi Wang, Ming Li, Haiping Fang, Yi Peng, Qihui Fan, Fangfu Ye
Summary: Microglia are resident macrophage cells in the central nervous system that migrate to search for pathogens or abnormal neural activities. This research reveals that microglia are promptly attracted by external forces, a behavior called mechanotaxis, which has not been confirmed in microglia before. The study also shows that microglial motion shares similarities with bacterial run-and-tumble motion, but with more sophistication, suggesting differences between eukaryotic and prokaryotic cells and their environments. This work provides a framework for studying immune cells exploring complex environments.
Article
Biochemistry & Molecular Biology
Zhen Jin, Yongjin Choi, Seong Young Ko, Jong-Oh Park, Sukho Park
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2017)
Article
Surgery
Muhammad Umar Farooq, Woo Young Kim, Seong Young Ko
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2018)
Article
Automation & Control Systems
Binxiang Xu, Chen Zhou, Seong Young Ko
INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS
(2018)
Article
Chemistry, Analytical
XueJun Jin, Jinwoo Jung, Seong Young Ko, Eunpyo Choi, Jong-Oh Park, Chang-Sei Kim
Article
Engineering, Biomedical
Phu Bao Nguyen, Byungjeon Kang, D. M. Bappy, Eunpyo Choi, Sukho Park, Seong Young Ko, Jong-Oh Park, Chang-Sei Kim
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2018)
Article
Surgery
Woo Young Kim, Seong Young Ko
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2019)
Article
Automation & Control Systems
Muhammad Umar Farooq, Seong Young Ko
INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS
(2020)
Article
Automation & Control Systems
Binxiang Xu, Seong Young Ko
Article
Chemistry, Multidisciplinary
Binxiang Xu, Liming An, Seong Young Ko
Summary: The study introduces a novel device for fracture reduction surgery, which has been evaluated through experiments to be simple, cost-effective, and accurate, meeting the practical needs in clinical settings.
APPLIED SCIENCES-BASEL
(2021)
Review
Robotics
Muhammad Umar Farooq, Seong Young Ko
Summary: Magnetic resonance imaging (MRI) provides better visualization for diagnosis, interventional radiology, and surgery without X-ray exposure. The symbiosis of MRI and robotics can improve patient outcomes and surgical convenience. Technological advancements have led to the development of MRI-compatible robots. This article reviews the literature on robotic systems developed for the MRI environment between 2009 and 2021, discussing surgical robots, sensing solutions, research emphasis, limitations, and prospects.
IEEE TRANSACTIONS ON ROBOTICS
(2023)
Article
Automation & Control Systems
Rongrong Liu, Farrukh Anique, Rongwan Chen, Sung Suk Oh, Jung Ki Jo, Seong Young Ko
Summary: This paper presents an automatic biopsy device that can be used in the MRI environment and works with a MR conditional robotic prostate biopsy system. The device, based on a compact cam design, can perform all actions required for prostate biopsy using a single actuator. Experimental evaluation showed that the device can easily and completely perform tissue sampling, with comparable performance to existing manual biopsy guns. MRI compatibility testing demonstrated a 18.7% reduction in signal-to-noise ratio during device operation.
Article
Automation & Control Systems
Muhammad Umar Farooq, Seong Young Ko, Sungmin Seung, Chaewon Kim, Kyoungrae Cha, Sung Suk Oh, Heon You
Summary: This study proposes the first MRI-compatible robotic system for pituitary tumor removal via trans-sphenoidal/endonasal access. The presented robot follows the gold standard procedure of pituitary tumor resection and integrates with a commercial MR scanner, providing wide applicability. It has procedure-, anatomy-, and geometry-specific design, with 6-degree-of-freedom actuated by a bed-type actuation platform in the MRI room. The robot's accuracy and repeatability are within a desirable range, and in vivo experiments on live porcine under MRI validate the proposed solution.
Article
Computer Science, Information Systems
Farrukh Anique, Rongrong Liu, Muhammad Umar Farooq, Sung Suk Oh, Jung Ki Jo, Seong Young Ko
Summary: Biopsies are a common method for diagnosing and prognosing prostate cancer, and advancements in MRI technology have allowed for real-time guidance during the biopsy process. A proposed device aims to collect and temporarily store tissue samples taken during an MRI-guided prostate biopsy, potentially enabling a teleoperated and uninterrupted procedure. The device, made of a double layer of paper, has been tested and optimized for tissue collection performance, as well as MRI compatibility. It shows potential for integration with an MRI-safe or conditional robotic manipulator for real-time MRI-guided prostate biopsy.
Proceedings Paper
Automation & Control Systems
Binxiang Xu, Seong Young Ko
2018 18TH INTERNATIONAL CONFERENCE ON CONTROL, AUTOMATION AND SYSTEMS (ICCAS)
(2018)
Article
Computer Science, Information Systems
Muhammad Umar Farooq, Hyunwoo Baek, Sungmin Seung, Kyoungrae Cha, Heon You, Dong-Soo Kwon, Seong Young Ko
