TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability

(2015) Jean-Hugues Guervilly et al.   MOLECULAR CELL

Noncovalent Interactions with SUMO and Ubiquitin Orchestrate Distinct Functions of the SLX4 Complex in Genome Maintenance

(2015) Jian Ouyang et al.   MOLECULAR CELL

Importin β-dependent nuclear import of TopBP1 in ATR–Chk1 checkpoint in Xenopus egg extracts

(2014) Liping Bai et al.   CELLULAR SIGNALLING

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication

(2014) D. Gritenaite et al.   GENES & DEVELOPMENT

Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks

(2014) Dong-Hyun Lee et al.   MOLECULAR CELL

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

(2014) A. Orthwein et al.   SCIENCE

Development of a simple method for the determination of nitrite and nitrate in groundwater by high-resolution continuum source electrothermal molecular absorption spectrometry

(2013) Geovani C. Brandao et al.   ANALYTICA CHIMICA ACTA

Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover

(2013) Barnabas Szakal et al.   EMBO JOURNAL

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability

(2013) Susanne M. Germann et al.   JOURNAL OF CELL BIOLOGY

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

(2013) T. Kruse et al.   JOURNAL OF CELL SCIENCE

Akt Switches TopBP1 Function from Checkpoint Activation to Transcriptional Regulation through Phosphoserine Binding-Mediated Oligomerization

(2013) K. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

TopBP1 Controls BLM Protein Level to Maintain Genome Stability

(2013) Jiadong Wang et al.   MOLECULAR CELL

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells

(2013) Audesh Bhat et al.   NUCLEIC ACIDS RESEARCH

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

(2013) Joao Matos et al.   Cell Reports

ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset

(2013) John Kenneth Eykelenboom et al.   Cell Reports

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells

(2012) Vibe H. Oestergaard et al.   DNA REPAIR

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

(2012) Kumiko Samejima et al.   JOURNAL OF CELL BIOLOGY

Cell cycle-dependent regulation of the nuclease activity of Mus81–Eme1/Mms4

(2012) María Gallo-Fernández et al.   NUCLEIC ACIDS RESEARCH

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

(2011) K. N. Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination

(2010) Susanne M. Germann et al.   DNA REPAIR

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

(2010) Rachele Cescutti et al.   EMBO JOURNAL

DNA Damage Signaling Recruits the Rtt107-Slx4 Scaffolds via Dpb11 to Mediate Replication Stress Response

(2010) Patrice Y. Ohouo et al.   MOLECULAR CELL

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei

(2010) Raquel A. Oliveira et al.   NATURE CELL BIOLOGY

Bright cyan fluorescent protein variants identified by fluorescence lifetime screening

(2010) Joachim Goedhart et al.   NATURE METHODS

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

(2009) Ivan M. Muñoz et al.   MOLECULAR CELL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Studying vertebrate topoisomerase 2 function using a conditional knockdown system in DT40 cells

(2009) M. Johnson et al.   NUCLEIC ACIDS RESEARCH

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE