TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability

Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover

(2013) Barnabas Szakal et al.   EMBO JOURNAL

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

(2013) Joao Matos et al.   Cell Reports

On the regulation, function, and localization of the DNA-dependent ATPase PICH

(2012) Manuel Kaulich et al.   CHROMOSOMA

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%

(2012) Joachim Goedhart et al.   Nature Communications

On the origins of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   CELL CYCLE

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

(2011) Boris Pfander et al.   EMBO JOURNAL

Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)

(2011) Laura A. Lindsey-Boltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromosome length influences replication-induced topological stress

(2011) Andreas Kegel et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation

(2011) Corentin Laulier et al.   NUCLEIC ACIDS RESEARCH

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier

(2011) Sevil Sofueva et al.   NUCLEIC ACIDS RESEARCH

New insights into the formation and resolution of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination

(2010) Susanne M. Germann et al.   DNA REPAIR

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

(2010) L. H.-C. Wang et al.   JOURNAL OF CELL SCIENCE

Cytokinesis failure occurs in Fanconi anemia pathway–deficient murine and human bone marrow hematopoietic cells

(2010) Patrizia Vinciguerra et al.   JOURNAL OF CLINICAL INVESTIGATION

The Bloom Syndrome Protein Limits the Lethality Associated with RAD51 Deficiency

(2010) K. Lahkim Bennani-Belhaj et al.   MOLECULAR CANCER RESEARCH

Bright cyan fluorescent protein variants identified by fluorescence lifetime screening

(2010) Joachim Goedhart et al.   NATURE METHODS

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage

(2010) Bethany L. Andreson et al.   NUCLEIC ACIDS RESEARCH

DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells

(2010) M Gandhi et al.   ONCOGENE

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

A mechanism for chromosome segregation sensing by the NoCut checkpoint

(2009) Manuel Mendoza et al.   NATURE CELL BIOLOGY

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Studying vertebrate topoisomerase 2 function using a conditional knockdown system in DT40 cells

(2009) M. Johnson et al.   NUCLEIC ACIDS RESEARCH

A New Purple Fluorescent Color Marker for Genetic Studies in Saccharomyces cerevisiae and Candida albicans

(2008) S. Keppler-Ross et al.   GENETICS

ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress

(2008) Rebecca A. Chanoux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dpb11 activates the Mec1-Ddc2 complex

(2008) D. A. Mordes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA