Article
Chemistry, Analytical
Yixin Hu, Jianyuan Wu, Xin Jiang, Guiying Chen, Yang Zhang, Luqin Si, Hongliang Jiang, Jiangeng Huang, Jianying Huang
Summary: A rapid, simple and sensitive LC-MS/MS method was developed and validated to quantify abiraterone and its metabolites in human plasma. The method showed good accuracy, precision and stability, making it suitable for pharmacokinetic studies.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
P. Poorna Basuri, R. Vijayakumar
Summary: The measurement of drug concentration in biological matrices is crucial for determining bioavailability and bioequivalence. In this study, a robust UHPLC-MS/MS method was developed and validated for the quantification of Minoxidil in human plasma. The method demonstrated high sensitivity and accuracy, and was successfully applied in a bioequivalence study.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Chang Shu, Teng-Fei Li, Duo Li, Zhong-Qiu Li, Xing-Hua Xia
Summary: Pomalidomide, an IMiD approved by the FDA for multiple myeloma treatment, was quantified in human plasma using a validated LC-MS/MS method. The method was successfully applied to clinical pharmacokinetic studies with positive results.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Xiangling Feng, Zhijie Deng, Jing Chen, Yufeng Ding, Heng Zheng
Summary: This study developed a rapid, sensitive, and robust UHPLC-MS/MS method for quantitative detection of crisaborole in human plasma. The method met the validation requirements of the US FDA and the European Medicines Agency and was successfully used in Chinese subjects.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Xin Shen, Gaofu Li, Libin Wang, Huijin Yu, Lei Zhou, Huifang Deng, Ningning Wang, Chengcai Lai, Wei Zhou, Yue Gao
Summary: This study evaluated the pharmacokinetics of acipimox in rats under simulated high altitude hypoxia conditions. A sensitive LC-MS/MS method was established for quantification of acipimox in rat plasma and tissue homogenate. The results showed significant differences in the pharmacokinetics parameters of acipimox between normoxic and hypoxic rats. Changes in lipid metabolism-related proteins and free fatty acid levels were also observed.
Article
Biochemical Research Methods
Lu-Ning Sun, Ye Zhang, Qiu-Chen Fang, Ye Shen, Xue Li, Chao Chen, Hong-Wen Zhang, Yong-Qing Wang
Summary: In this study, a rapid and reproducible method was established for quantification of HCP002 in urine and plasma. HCP002 is a phosphate-modified derivative of voriconazole that improves solubility without the use of nephrotoxic solubilizers.
Article
Chemistry, Analytical
Amira S. Gouda, Ahmed M. Abdel-Megied, Mamdouh R. Rezk, Hoda M. Marzouk
Summary: A bioanalytical LC-MS/MS method was developed and validated for the quantification of baloxavir acid in the plasma of healthy volunteers. The method was successfully applied for a pharmacokinetic study and demonstrated reliability and stability.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
In-Hwan Park, Jin-Woo Park, Hyewon Chung, Jong-Min Kim, Sangjin Lee, Kyoung-Ah Kim, Ji-Young Park
Summary: A novel and sensitive liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of dabigatran etexilate, dabigatran, and dabigatran acylglucuronide in human plasma samples. The method was successfully applied to determine the pharmacokinetic profiles of these components in humans, demonstrating its robust, reliable, and sensitive characteristics.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Joshua A. Reeder, Inas A. Abdallah, Thanh Bach, Cormac T. O'Sullivan, Yan Xu, Demet Nalbant, Guohua An
Summary: Cefazolin is commonly used to prevent surgical site infections during surgery, but the appropriate redosing schedule is controversial. A new LC-MS/MS method for quantifying cefazolin in human plasma was developed, with accurate results and validation criteria met. This method offers a simple sample preparation, short analysis time, wide dynamic range, and low limit of quantification, making it a reliable tool for determining cefazolin concentrations in clinical settings.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Hongjiang Xu, Yanan Li, Jing Zhang, Jinhua Zhang, Jianguang Lu, Xiquan Zhang, Ling Yang, Wenjie Zhao, Jun Feng
Summary: A rapid UHPLC-MS/MS assay method was developed for the determination of CMS E2 and colistin E2 in human plasma. The method demonstrated speed and high accuracy, and was successfully applied to the analysis of plasma samples obtained from Chinese healthy volunteers.
SCIENTIFIC REPORTS
(2023)
Article
Biochemical Research Methods
Chenxi Liu, Miqun Zhu, Liyun Cao, Hamza Boucetta, Min Song, Taijun Hang, Yuting Lu
Summary: A LC-MS/MS method was established and validated for simultaneous determination of nirmatrelvir and ritonavir in human plasma. The method demonstrated excellent precision, accuracy, recovery, and linearity, and was used to evaluate the pharmacokinetic profile of Paxlovid in healthy Chinese volunteers, showing consistent results with a previous study on Western volunteers.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Chemistry, Analytical
Rong Yang, Shuang Ren, Xiaowei Jin, Yu Sun, Yanli Dong, Jinwei Zhang, Wenzhong Liang, Li Chen
Summary: A method was developed and validated for determining the unbound fraction of dorzagliatin in human plasma, successfully addressing challenges such as lack of knowledge on the true unbound fraction and difficulty in assessing the accuracy and reproducibility of the measurement. The method was applied in a clinical PK study of dorzagliatin in healthy volunteers and patients with renal function impairment, providing reliable analytical results for PK/PD interpretation and valuable insight for drug development.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Lu Liu, Le Yang, Wei Li, Xiaoyan Chen
Summary: In this study, we developed a sensitive and reliable LC-MS/MS method for quantifying almonertinib and its metabolite HAS-719. We also investigated the pharmacokinetic effects of these compounds in humans using modulators of CYP3A, an enzyme involved in the metabolism of almonertinib. The method was successfully applied to evaluate the pharmacokinetics of almonertinib in healthy subjects exposed to a single dose of the drug.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Plant Sciences
Qian Liu, Chunmin Li, Pan Zhao, Jing Li, Zhipeng Deng
Summary: This study developed a sensitive and selective LC-MS/MS assay for quantifying thonningianin A in rats after oral administration. The results showed that plasma concentrations of thonningianin A increased rapidly and reached peak concentrations within a short time.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Daya Raju Adye, Sachin B. Jorvekar, Upadhyayula Suryanarayana Murty, Subham Banerjee, Roshan M. Borkar
Summary: Analytical sample preparation techniques are crucial for evaluating chemicals in different biological matrices, and the development of extraction techniques is a contemporary trend in bioanalytical sciences.
Review
Pharmacology & Pharmacy
Venkata Yellepeddi, Joseph Rower, Xiaoxi Liu, Shaun Kumar, Jahidur Rashid, Catherine M. T. Sherwin
CLINICAL PHARMACOKINETICS
(2019)
Article
Pharmacology & Pharmacy
Sarah M. Becker, Kathleen M. Job, Kelly Lima, Ty J. Forbes, Jadon Wagstaff, Nam K. Tran, Catherine M. Sherwin, Douglas S. Nelson, Michael D. Johnson, Joseph E. Rower
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Ashley M. Reilly, Michelle X. Ding, Joseph E. Rower, Tyree H. Kiser
JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Chemistry, Analytical
Joseph E. Rower, David J. Anderson, Catherine M. Sherwin, Christopher A. Reilly, Philip L. Ballard, Cindy T. McEvoy, Diana G. Wilkins
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2019)
Article
Clinical Neurology
A. Cameron Hill, Joseph E. Rower, H. Steve White
Article
Pediatrics
Cindy T. McEvoy, Philip L. Ballard, Robert M. Ward, Joseph E. Rower, Rajan Wadhawan, Mark L. Hudak, Joern-Hendrik Weitkamp, Julia Harris, Jeanette Asselin, Cheryl Chapin, Roberta A. Ballard
PEDIATRIC RESEARCH
(2020)
Article
Chemistry, Analytical
Joseph E. Rower, Chris Nielson, Kevin Shi, Albert H. Park
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Oncology
Eman Biltaji, Elena Y. Enioutina, Venkata Yellepeddi, Joseph E. Rower, Catherine M. T. Sherwin, Robert M. Ward, Richard S. Lemons, Jonathan E. Constance
LEUKEMIA & LYMPHOMA
(2020)
Article
Oncology
Joseph E. Rower, Amber D. King, Diana Wilkins, Jacob Wilkes, Venkata Yellepeddi, Luke Maese, Richard S. Lemons, Jonathan E. Constance
Summary: Dronabinol is used in cancer patients for treating chemotherapy-induced nausea and vomiting, with a steady increase in its use over the past decade. Concentrations of THC and its metabolites in children receiving dronabinol were consistently low or undetectable.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nam D. Nguyen, Tosifa A. Memon, Katherine L. Burrell, Marysol Almestica-Roberts, Emmanuel Rapp, Lili Sun, Abigail F. Scott, Joseph E. Rower, Cassandra E. Deering-Rice, Christopher A. Reilly
MOLECULAR PHARMACOLOGY
(2020)
Article
Engineering, Biomedical
Carina E. Imburgia, Joseph E. Rower, Danielle J. Green, Autumn M. Mcknite, Walter E. Kelley, Christopher A. Reilly, Kevin M. Watt
Summary: The study found significant drug loss of RDV and its metabolite in ECMO and CRRT circuits, mainly due to drug adsorption by circuit materials or efficient hemodiafiltration.
Article
Cell Biology
Jessica L. Freeling, Jamie L. Scholl, Morgan Eikanger, Cole Knoblich, Rashaun A. Potts, David J. Anderson, Joseph E. Rower, Mohammad Hadi Farjoo, Haotian Zhao, Angela Pillatzki, Khosrow Rezvani
Summary: A high-throughput drug screen identified veratridine (VTD) as a potential targeted therapy in colon cancer cells by inducing UBXN2A expression and deactivating mortalin. In vivo studies showed that VTD effectively induced UBXN2A expression in mice without causing neurotoxicity or cardiotoxicity. Mouse xenograft experiments demonstrated the ability of VTD to suppress tumor growth. These findings support the potential utility of VTD as a safe and efficacious anti-cancer molecule.
CELL DEATH DISCOVERY
(2022)
Article
Clinical Neurology
Jeffrey A. Mensah, Kristina Johnson, Christopher A. Reilly, Karen S. Wilcox, Joseph E. Rower, Cameron S. Metcalf
Summary: This study demonstrates the utility of PK analyses for understanding the seizure protection time course in mice and rats. The data indicate that distinct PK profiles of ASMs between mice and rats likely drive differences in drug efficacy between rodent models.
Article
Medicine, Research & Experimental
Venkata K. K. Yellepeddi, Marco Battaglia, Simon J. C. Davies, Jeremiah Alt, Shaelene Ashby, Paige Shipman, David J. J. Anderson, Joseph E. Rower, Christopher Reilly, Michael Voight, Sabiha Rahman Mim
Summary: Anxiety and panic disorders are common mental illnesses with limited treatment options in the United States. Acid-sensing ion channels (ASICs) in the brain play a role in fear conditioning and anxiety responses, making them potential targets for treating panic disorder. Amiloride, an ASICs inhibitor, has shown promise in reducing panic symptoms in animal models. This study evaluated the pharmacokinetics and safety of intranasal amiloride in healthy human volunteers, demonstrating its rapid absorption and safety at various doses.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Anesthesiology
Tatjana Bevans, Cassandra Deering-Rice, Chris Stockmann, Joseph Rower, Derek Sakata, Christopher Reilly
ANESTHESIA AND ANALGESIA
(2017)