Article
Pharmacology & Pharmacy
Haiyan Yang, Cancan He, Yang Bi, Xu Zhu, Dan Deng, Tingting Ran, Xiaojuan Ji
Summary: This study found that VEGF and SDF-1 alpha synergistically enhance the migration, differentiation, and proliferation capabilities of EPCs, but not VSMCs. This finding provides a promising strategy for the prevention of vascular stenosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo, Raija Lithovius, Sinnakaruppan Mathavan, Markku Lehto, Timo P. Hiltunen, Kimmo K. Kontula, Per-Henrik Groop
Summary: This study investigated the effect of L-type calcium channel blockers (LTCCBs) on VEGF concentrations in retinal cells and human serum, and evaluated the association between LTCCB usage and risk of severe diabetic eye disease (SDED). The results showed that LTCCBs increase VEGF concentrations in retinal cells and human serum, but they are not associated with the risk of SDED in adults with type 1 diabetes.
Article
Engineering, Biomedical
Mi Hu, Fan Jia, Wei-Pin Huang, Xu Li, Deng-Feng Hu, Jing Wang, Ke-Feng Ren, Guo-Sheng Fu, Yun-Bing Wang, Jian Ji
Summary: The stiffness of the vascular extracellular matrix plays a crucial role in artery pathology and can impact the autophagy levels of vascular endothelial cells and smooth muscle cells. Increasing substrate stiffness leads to differential changes in autophagy levels, affecting gene expression associated with endothelial function and transitioning VSMCs from contractile to synthetic phenotype. Inhibiting cell autophagy further reduces endothelial functional gene expression and increases VSMC calponin expression, highlighting the important role of autophagy in response to changes in microenvironment stiffness.
BIOACTIVE MATERIALS
(2021)
Article
Hematology
Ting-Yi Tien, Yih-Jer Wu, Cheng-Huang Su, Hsueh-Hsiao Wang, Chin-Ling Hsieh, Bo-Jeng Wang, Yeu Su, Hung- Yeh
Summary: Circulating progenitor cells have vasculogenic properties and can participate in repairing vascular injuries. The gap junction protein Cx43 plays a crucial role in regulating the cellular function and paracrine effects of smooth muscle progenitor cells (SPCs) through the FAK-Src axis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cell Biology
Yu-Xia Zhang, Ri-Ning Tang, Li-Ting Wang, Bi-Cheng Liu
Summary: Chronic kidney disease (CKD) is a significant health issue globally, with vascular calcification (VC) playing a major role in the cardiovascular morbidity and high mortality of CKD. Intercellular crosstalk between ECs and SMCs is crucial in the development of VC associated with CKD.
CELL PROLIFERATION
(2021)
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ningning Sun, Beyongsam Chu, Dong-Hyun Choi, Leejin Lim, Heesang Song
Summary: Abnormal communication between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) promotes vascular diseases. ETS variant transcription factor 2 (ETV2) plays a role in pathological angiogenesis, but its role in the communication between ECs and VSMCs is unknown. CXCL5 induced by ETV2 in ECs promotes VSMC migration through MMP upregulation and the activation of Akt and p38/c-Jun.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Priya Raman, Saugat Khanal
Summary: Leptin plays a crucial role in the pathogenesis of atherosclerotic complications associated with obesity and diabetes. Elevated levels of leptin can lead to vascular dysfunction and the development of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Laura Locatelli, Sara Castiglioni, Jeanette A. M. Maier
Summary: This review article discusses the effects of space environment on the human vasculature and the adaptive responses activated in such conditions. The study suggests that oxidative stress and mitochondrial dysfunction might be mediators of vascular alterations in space. Understanding the cellular and molecular mechanisms involved in these adaptive processes could provide insights for designing proper countermeasures for space exploration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Xiaoyu Wang, Bin Gao, Xiang-kui Ren, Jintang Guo, Shihai Xia, Wencheng Zhang, Cheng Yang, Yakai Feng
Summary: This study developed a strategy for synchronizing promotion of endothelial cells and inhibition of smooth muscle cells, providing a new approach for the treatment of vascular restenosis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Cardiac & Cardiovascular Systems
Michael M. Orlich, Rodrigo Dieguez-Hurtado, Regine Muehlfriedel, Vithiyanjali Sothilingam, Hartwig Wolburg, Cansu Ebru Oender, Pascal Woelffing, Christer Betsholtz, Konstantin Gaengel, Mathias Seeliger, Ralf H. Adams, Alfred Nordheim
Summary: This study reveals the crucial role of the transcription factor SRF in pericytes and vascular smooth muscle cells, which is essential for maintaining vascular integrity and tone.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mojtaba Parvizi, Zachary C. Ryan, Sanam Ebtehaj, Bonnie K. Arendt, Ian R. Lanza
Summary: Research has shown that senescent preadipocytes can induce an inflammatory phenotype, decrease cell viability, disrupt proliferation and migration, affecting the occurrence of vascular diseases by triggering phenotypic and functional changes in key cellular components of blood vessels.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Carmen Gutierrez-Munoz, Luis Miguel Blanco-Colio
Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Misato Ueda, Yasuki Hirayama, Haruo Ogawa, Tadashi Nomura, Hiroto Terashi, Shunsuke Sakakibara
Summary: This study aimed to investigate the vasodilatory effects and cytotoxicity of various vasodilators used as antispasmodic agents during microsurgical anastomosis. The results showed that lidocaine, papaverine, and nitroglycerin had vasodilatory effects but also exhibited cytotoxicity, while phentolamine and olprinone showed antispasmodic effects without cytotoxicity. The concentrations of the vasodilators required for vasodilation were lower than the reported clinical concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Iwona Lopianiak, Michal Wojasinski, Aleksandra Kuzminska, Paulina Trzaskowska, Beata A. Butruk-Raszeja
Summary: Changing the morphology and average fiber diameter of materials can influence the growth of endothelial cells and smooth muscle cells. Endothelial cells are significantly influenced by the morphology and fiber diameter of scaffolds, while smooth muscle cells show better growth on micron fibers.
JOURNAL OF BIOLOGICAL ENGINEERING
(2021)
Article
Materials Science, Biomaterials
Jia-yan Chen, Mi Hu, He Zhang, Bo-chao Li, Hao Chang, Ke-feng Ren, Yun-bing Wang, Jian Ji
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Jia-yan Chen, Mi Hu, He Zhang, Bo-chao Li, Hao Chang, Ke-feng Ren, Yun-bing Wang, Jian Ji
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Biochemical Research Methods
Mingyue Cui, Hao Change, Yang Zhong, Min Wang, Tianze Wu, Xiao Hu, Zhichuan J. Xu, Chenjie Xu
Article
Chemistry, Multidisciplinary
Mengjia Zheng, Christian Wiraja, David C. Yeo, Hao Chang, Daniel Chin Shiuan Lio, Wei Shi, Kanyi Pu, Amy S. Paller, Chenjie Xu
Article
Multidisciplinary Sciences
Aung Than, Chenghao Liu, Hao Chang, Phan Khanh Duong, Chui Ming Gemmy Cheung, Chenjie Xu, Xiaomeng Wang, Peng Chen
NATURE COMMUNICATIONS
(2018)
Article
Biochemical Research Methods
Sharon W. T. Chew, Yongpeng Zeng, Mingyue Cui, Hao Chang, Mengjia Zheng, Shi Wei, Wenting Zhao, Chenjie Xu
Review
Polymer Science
Ke-feng Ren, Mi Hu, He Zhang, Bo-chao Li, Wen-xi Lei, Jia-yan Chen, Hao Chang, Li-mei Wang, Jian Ji
PROGRESS IN POLYMER SCIENCE
(2019)
Article
Engineering, Biomedical
Min Wang, Yiyuan Han, Xiaojun Yu, Liangliang Liang, Hao Chang, David C. Yeo, Christian Wiraja, Mei Ling Wee, Linbo Liu, Xiaogang Liu, Chenjie Xu
ADVANCED HEALTHCARE MATERIALS
(2020)
Review
Materials Science, Multidisciplinary
Hao Chang, Mengjia Zheng, Sharon Wan Ting Chew, Chenjie Xu
ADVANCED MATERIALS TECHNOLOGIES
(2020)
Article
Engineering, Biomedical
Mengjia Zheng, Zifeng Wang, Hao Chang, Lulu Wang, Sharon W. T. Chew, Daniel Chin Shiuan Lio, Mingyue Cui, Linbo Liu, Benjamin C. K. Tee, Chenjie Xu
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Engineering, Biomedical
Hao Chang, Sharon W. T. Chew, Mengjia Zheng, Daniel Chin Shiuan Lio, Christian Wiraja, Yu Mei, Xiaoyu Ning, Mingyue Cui, Aung Than, Peng Shi, Dongan Wang, Kanyi Pu, Peng Chen, Haiyan Liu, Chenjie Xu
Summary: Cryogenic microneedle patches can be used for transdermal delivery of mammalian cells in mice before dissolving into the skin, as shown with the delivery of ovalbumin-pulsed dendritic cells in mice with subcutaneous tumors.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Hao Chang, Xueyu Wen, Zhiming Li, Zhixin Ling, Yanting Zheng, Chenjie Xu
Summary: This study demonstrates the potential of cryoMNs as a co-delivery system for cancer immunotherapy. Unlike conventional microneedles, cryoMNs can effectively co-deliver dendritic cell vaccines and anti-PD-1 antibodies, increasing their potential for tumor treatment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Zhiming Li, Puxuan Zhao, Zhixin Ling, Yanting Zheng, Fengli Qu, Hao Chang
Summary: This article reports the development of an ultraswelling microneedle device that allows for easy and efficient loading and transdermal delivery of hydrophilic drugs with different molecular weights. It outperforms conventional administration methods in reducing psoriasis and inducing immunity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Sharon W. T. Chew, Ankur H. Shah, Mengjia Zheng, Hao Chang, Christian Wiraja, Terry W. J. Steele, Chenjie Xu
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2020)
Article
Biophysics
Hao Chang, He Zhang, Mi Hu, Jia-yan Chen, Bo-chao Li, Ke-feng Ren, M. Cristina L. Martins, Mario A. Barbosa, Jian Ji
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.