Article
Engineering, Biomedical
Yi You, Yu Tian, Zhaogang Yang, Junfeng Shi, Kwang Joo Kwak, Yuhao Tong, Andreanne Poppy Estania, Jianhong Cao, Wei-Hsiang Hsu, Yutong Liu, Chi-Ling Chiang, Benjamin R. Schrank, Kristin Huntoon, DaeYong Lee, Ziwei Li, Yarong Zhao, Huan Zhang, Thomas D. Gallup, JongHoon Ha, Shiyan Dong, Xuefeng Li, Yifan Wang, Wen-Jing Lu, Eman Bahrani, Ly James Lee, Lesheng Teng, Wen Jiang, Feng Lan, Betty Y. S. Kim, Andrew S. Lee
Summary: The study found that extracellular vesicles (EVs) produced through cellular nanoporation can safely and effectively translate genetic material into functional proteins. In mice with photoaged skin, EVs carrying mRNA encoding for collagen induced collagen-protein grafts and reduced wrinkle formation. Intradermal delivery of mRNA-loaded EVs through a microneedle array resulted in prolonged and more uniform synthesis and replacement of collagen in the dermis. Intradermal delivery of EV-based COL1A1 mRNA may be an effective protein-replacement therapy for treating photoaged skin.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Bao T. Le, Sibasish Paul, Katarzyna Jastrzebska, Heera Langer, Marvin H. Caruthers, Rakesh N. Veedu
Summary: Recent advances in drug development have shown successful clinical translations using synthetic antisense oligonucleotides (ASOs). However, challenges such as large-scale production, toxicity, localization, and high cost of treatment need to be addressed. Thiomorpholino oligonucleotides (TMOs) have emerged as a potential solution, as they can be synthesized using solid-phase oligonucleotide synthesis methodologies. This study demonstrates that TMOs can efficiently induce exon skipping in a Duchenne muscular dystrophy (DMD) in vitro model and perform well at low concentrations, potentially improving the drug safety profile.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nanoscience & Nanotechnology
Xuanqi Chen, Hao Wan, Rui Guo, Xinpeng Wang, Yang Wang, Caicai Jiao, Kang Sun, Liang Hu
Summary: This paper presents a miniaturized liquid metal-based flexible electrochemical detection system on fabric. The system is intrinsically flexible, air-permeable, and conformable to the body. By taking advantage of the excellent fluidity and electrical connectivity of liquid metal, a double-layer circuit is fabricated that significantly reduces the size of the system. The system demonstrates good stability, repeatability, and the ability to detect glucose in sweat at the millimolar level.
MICROSYSTEMS & NANOENGINEERING
(2022)
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Min Chen, Jingyu Ouyang, Aijia Jian, Jia Liu, Pan Li, Yixue Hao, Yuchen Gong, Jiayu Hu, Jing Zhou, Rui Wang, Jiaxi Wang, Long Hu, Yuwei Wang, Ju Ouyang, Jing Zhang, Chong Hou, Lei Wei, Huamin Zhou, Dingyu Zhang, Guangming Tao
Summary: Flexible sensors, friendly interfaces, and intelligent recognition are important in the research of human-computer interaction and smart device development. This article presents a low-cost, automated fabrication method for a braided electronic cord that allows for imperceptible, designable, and scalable user interfaces. A multi-feature fusion algorithm is used to recognize gestures on the cord, providing high-precision interaction. The cord's user-friendly features, durability, and rich interaction mode have great potential for advancing human-machine integration.
NATURE COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Wenqing Wang, Md Osman Goni Nayeem, Haoyang Wang, Chunya Wang, Jae Joon Kim, Binghao Wang, Sunghoon Lee, Tomoyuki Yokota, Takao Someya
Summary: A humidity sensor composed of nanomesh Au electrodes and nanomesh humidity-sensitive materials is reported, which has high sensitivity and gas permeability for measuring the sweat rate on the human skin surface. The porous structure makes the sensor flexible and increases the surface area, which is crucial for continuous monitoring.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Pharmacology & Pharmacy
Madia Lozupone, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Roberta Stallone, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vincenzo Solfrizzi, Francesco Panza
Summary: Tauopathies are characterized by increased and abnormal glial and/or neuronal inclusions of tau, a microtubule-binding protein. Antisense oligonucleotides (ASOs) and peptides are promising therapeutic approaches for tauopathies. ASOs can target tau mRNA to reduce tau expression, while peptides specifically target tau. This review explores the chemical basis of designing ASOs and peptides for treating tauopathies, highlighting BIIB080 as the first ASO in clinical trial development for mild Alzheimer's disease and discussing the therapeutic potential of peptide 021 (P021) based on preclinical studies.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Medicine, General & Internal
Wioleta Grabowska-Pyrzewicz, Andrew Want, Jerzy Leszek, Urszula Wojda
Summary: Alzheimer's disease poses a therapeutic challenge due to its complex etiology, with recent progress in ASO-based approaches showing promising potential for multi-targeted therapy.
Article
Cell Biology
Kento Takaya, Toru Asou, Kazuo Kishi
Summary: There is growing evidence that senescent dermal fibroblasts play a significant role in the aging process of the skin, affecting its appearance and texture. Secreted frizzled-related protein 4 (SFRP4) has been found to promote cellular senescence and contribute to the senescence-associated secretory phenotype (SASP). Knockdown of SFRP4 in mouse skin shows promising results in improving age-related changes in subcutaneous adipose tissue, muscle layer, and collagen fibers.
Review
Chemistry, Multidisciplinary
Jianwen Chen, Yutian Zhu, Xiaohua Chang, Duo Pan, Gang Song, Zhanhu Guo, Nithesh Naik
Summary: Inspired by human skin, electronic skins (e-skins) utilize flexible sensors and delicate circuits to mimic the sensing functions of human skin, including strain, pressure, shear force, temperature, and humidity sensing abilities, as well as self-healing capabilities. This review summarizes strategies to achieve versatile functionalities of natural skin-like e-skins, outlines representative examples of high-performance e-skins and their applications, and provides an outlook for the future of e-skins.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nutrition & Dietetics
Maysa Alves Rodrigues Brandao-Rangel, Carlos Rocha Oliveira, Fabiana Regina da Silva Olimpio, Flavio Aimbire, Jose Roberto Mateus-Silva, Felipe Augusto Chaluppe, Rodolfo P. Vieira
Summary: This study investigated the effects of collagen peptides on the proliferation and activation of fibroblasts and keratinocytes. The results showed that collagen peptides can promote cell proliferation and reduce inflammatory responses caused by lipopolysaccharide.
Article
Chemistry, Analytical
Courtney Chheng, Denise Wilson
Summary: Abnormalities and irregularities in walking can be predicted and identified using wearable gait sensors, which offer the potential to improve care quality and diagnosis. By analyzing data collected from sensors, it was found that stride width variability and cadence can accurately differentiate abnormal or irregular strides from normal ones. This non-contact Hall-effect sensing method is highly sensitive and can detect visually imperceptible gait variability in natural settings, providing valuable information for predicting disease progression and injury recovery.
Article
Dermatology
Hyun Jeong Ju, Ju Yeong Lee, Ju Hee Han, Ji Hae Lee, Jung Min Bae, Solam Lee
Summary: This nationwide population-based study conducted in South Korea investigated the incidence and risk of autoimmune connective tissue disorders following mRNA-based COVID-19 vaccination. The results suggest that the risk of most autoimmune connective tissue disorders is not significantly increased in vaccinated individuals compared to controls. However, caution is necessary when interpreting the results for rare outcomes.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Shanshan Zhu, Yuanhen Li, Huoerhut Yelemulat, Xinping Deng, Yongchen Li, Jingjing Wang, Xiaojian Li, Guanglin Li, Paschalis Gkoupidenis, Yanlong Tai
Summary: Flexible tactile neuromorphic devices are important for human-machine collaboration, and this study presents a self-powered stretchable 3D remote tactile device that can sense the depth-of-field motion of external objects through a conductive-dielectric structure. The device establishes a logic relationship between the motion and sensory signals, and its performance is verified through an artificial-biological hybrid system. The feasibility of using this device as an obstacle-avoidance patch for the blind is demonstrated, paving the way for multimodal neuromorphic devices with brain-like intelligence capabilities.
Article
Multidisciplinary Sciences
Lixue Tang, Jin Shang, Xingyu Jiang
Summary: This multilayer electronic tattoo is highly stretchable, conformal, and sticky, enabling the crease amplification effect for integrated strain sensors. It is easy to fabricate, scalable, and can be used for temperature adjustment, movement monitoring, and remote control of robots.
Article
Biotechnology & Applied Microbiology
Hao Chang, Xueyu Wen, Zhiming Li, Zhixin Ling, Yanting Zheng, Chenjie Xu
Summary: This study demonstrates the potential of cryoMNs as a co-delivery system for cancer immunotherapy. Unlike conventional microneedles, cryoMNs can effectively co-deliver dendritic cell vaccines and anti-PD-1 antibodies, increasing their potential for tumor treatment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Fang Liu, Yingzhi Luo, Huan Chen, Shengjing Xu, Dongyan Zhang, Hong Sang, Chenjie Xu, Min Zhang
Summary: Microneedle technology effectively suppresses the formation of hypertrophic scarring in both animals and humans. This article examines the influence of microneedle fabrication materials on rabbit ear hypertrophic scar model. Among the different materials tested, polymethylmethacrylate microneedles showed the best results in reducing tissue fibrosis and expression of biomarkers, while polycarbonates, polyurethane, and polylactic-co-glycolic acid microneedles could also suppress the expression of these biomarkers.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Xiang Wu, Fan Yang, Sa Cai, Kanyi Pu, Guosong Hong
Summary: The NIR-II window, ranging from 1000 to 1700 nm in wavelength, allows for deep-penetration fluorescent imaging in biological tissues due to reduced light scattering. Recently, deep-brain neuromodulation has been achieved in the NIR-II window using nanotransducers that convert NIR-II light into heat. This Perspective discusses the principles, potential applications, advantages, and limitations of this NIR-II deep-brain neuromodulation technique, as well as future directions for advancement.
Review
Chemistry, Multidisciplinary
Chi Zhang, Kanyi Pu
Summary: This review discusses the convergence of sonodynamic therapy (SDT) with cancer immunotherapy to overcome their limitations for clinical translation. The focus is on the development of organic materials with high sonodynamic activity and immunotherapeutic efficiency. SDT induces immunogenic cell death to improve tumor immunogenicity, and immunotherapy drugs activate antitumor immunity through immune pathway modulation.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Cheng Xu, Shasha He, Xin Wei, Jingsheng Huang, Mengke Xu, Kanyi Pu
Summary: In this study, a ultrasound-induced afterglow (sonoafterglow) nanoprobe, named Q-SNAP, was developed for real-time imaging of T-cell immunoactivation. The probe specifically detects granzyme B and has a low limit of detection. Q-SNAP can not only distinguish autoimmune hepatitis from healthy liver at an early stage, but also monitor the reversal of T-cell hyperactivation. It offers the possibilities of dynamic monitoring of T-cell dysfunction and evaluation of immunotherapy in deep-seated lesions.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jingchao Li, Ningyue Yu, Dong Cui, Jiaguo Huang, Yu Luo, Kanyi Pu
Summary: This study presents the construction of semiconducting polymer pro-nanomodulators (SPpMs) for deep-tissue sono-immunotherapy of orthotopic pancreatic cancer. Through ultrasound treatment, SPpMs can generate singlet oxygen molecules to ablate tumors and release immunomodulators, enhancing antitumor immune response.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jie Yu, Shasha He, Chi Zhang, Cheng Xu, Jingsheng Huang, Mengke Xu, Kanyi Pu
Summary: We report the development of polymeric STING pro-agonists (PSPA) for cancer sono-immunotherapy. PSPA is activated by sono-irradiation and elevated GSH within the tumor microenvironment (TME). Under sono-irradiation, PSPA generates O-1(2) and induces immunogenic cell death (ICD) of malignant tumor cells. Furthermore, the release of STING agonist (MSA-2) is specific to the tumor microenvironment with highly expressed GSH, minimizing off-target side effects. The activation of the STING pathway synergizes with SDT to enhance the anti-tumor response.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Penghui Cheng, Shasha He, Chi Zhang, Jing Liu, Kanyi Pu
Summary: A tandem-locked NETosis reporter was developed for specific imaging of NETosis. This reporter can differentiate NETosis from neutrophil activation and provide prognosis for cancer immunotherapy. The study demonstrates a sensitive optical reporter for noninvasive monitoring of NETosis levels and evaluation of cancer immunotherapeutic efficacy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jingsheng Huang, Chi Zhang, Xinzhu Wang, Xin Wei, Kanyi Pu
Summary: There is a growing interest in developing chemiluminescence (CL) probes for phototheranostics, which can minimize tissue autofluorescence. However, the lack of near-infrared (NIR)-absorbing chemiluminophores has led to the use of nanoparticle-based probes for NIR CL-guided phototherapy. This study introduces bright unimolecular chemiluminophores with NIR absorptions and emissions, long CL half-lives, and optimal photodynamic efficiency. One of these luminophores, DBPOL, is modified into an activatable probe that exhibits a turn-on CL signal and photodynamic activity specific to a cancer biomarker. The highly sensitive DBPOL allows for CL-guided photodynamic therapy, effectively inhibiting tumor growth and lung metastasis in mouse models, and enabling noninvasive monitoring of lung metastasis. Molecular guidelines for NIR-absorbing CL probes for imaging-guided phototherapy are provided.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jingru Xu, Mengjia Zheng, Dexter Kai Hao Thng, Tan Boon Toh, Lei Zhou, Glenn Kunnath Bonney, Yock Young Dan, Pierce Kah Hoe Chow, Chenjie Xu, Edward Kai-Hua Chow
Summary: SALL4 is an oncofetal protein that drives cancer progression and poor prognosis in hepatocellular carcinoma and hematological malignancies. Due to the lack of well-structured binding pockets, targeted inhibitors for SALL4 are difficult to design. In this study, an AI-assisted platform utilizing molecular beacons and nanodiamonds was developed to evaluate patient-specific drug sensitivity for HCC treatment, providing efficient and rapid clinical decision support.
Review
Pharmacology & Pharmacy
Jiahui He, Yuyue Zhang, Xinge Yu, Chenjie Xu
Summary: Transdermal drug delivery systems, particularly wearable patches, have advantages such as good drug bioavailability and patient compliance. The integration of stimulus-responsive materials and electronics in such systems allows for dosage, temporal, and spatial control of therapeutics delivery.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Biomedical
Zhiming Li, Puxuan Zhao, Zhixin Ling, Yanting Zheng, Fengli Qu, Hao Chang
Summary: This article reports the development of an ultraswelling microneedle device that allows for easy and efficient loading and transdermal delivery of hydrophilic drugs with different molecular weights. It outperforms conventional administration methods in reducing psoriasis and inducing immunity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Editorial Material
Pharmacology & Pharmacy
Wei He, Alejandro Sosnik, Chenjie Xu
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Chemistry, Multidisciplinary
Xinzhu Wang, Kanyi Pu
Summary: This tutorial review discusses the recent advances in molecular afterglow imaging, including a comprehensive summary of reported afterglow substrates and mechanisms. The molecular designs of multicomponent afterglow imaging probes are also introduced, along with their biomedical applications in disease diagnosis and treatment. Lastly, future perspectives and potential challenges of molecular afterglow imaging in preclinical uses and clinical translations are discussed.
CHEMICAL SOCIETY REVIEWS
(2023)
